Fengxizeng

Professor Feng is the doctoral supervisor of College of Life Sciences, Nankai University. From 1993 to 1996, he studied and obtained the PhD. from the Department of Chemistry, Nankai University. From 1996 to 2003, he was engaged in postdoctoral research in the Institute of Chemistry of the Chinese Academy of Sciences, the United States, and the United Kingdom. Prof. Feng returned back to China in 2003 and was appointed as a distinguished professor at Nankai University. The main research interests include the influencing mechanism of murine oocyte maturation, the treatment of Parkinson's drugs in Parkinson's model rats and the mechanisms, and the neurobiological research of zebrafish.

From 1993 to 1996, studied for Ph. D at Department of Chemistry, Nankai University From 1996 to 1998, postdoctoral research in Institute of Chemistry, Chinese Academy of Sciences From 1998 to 2003, postdoctoral research in America and the United Kingdom

From 2003 to present, professor and doctoral tutor at College of Life Sciences, Nankai University

1. Mouse development and oocyte maturation: The present study is the molecular mechanism and epigenetic genetics of the effects of environmental hormones and endocrine disruptors on mouse development and oocyte maturation, to study the effect of delaying cell cycle, micro-tube assembly and the level of related protein phosphorylation methylation, and to analyze whether it can cause the early apoptosis and autophagy effect.

  

2. Parkinson's drug research direction: Construct PD mouse model to study the improvement effect of Parkinson's drugs and its treatment mechanism at the behavioral and molecular level, and to find the active substances with levodopa in order to reduce the side effects caused by levodopa excess.

  

3. The research of the zebrafish field is focus on behaviors and neuroscience of zebrafish. We use zebrafish as a model to study the effects of some chemicals, such as endocrine disrupting chemicals, nanoparticles, environmental polluants, pesticide (insecticide), herbicide (weed killer), observe the toxicity of development, the effect on behaviors, such as sleep/wake behavior. At the same time, we also establish disease models, such as anxiety, depression, epilepsy models to study the effects of drugs on these diseases. We also connect behaviors research with histochemical and molecular biology methods to learn more about these mechanisms.

Publications in recent years

1. Du Shuangli #, Wang Hongyu #, Yang Yueyue, Feng Xizeng*, Shao Xueguang, Chipot Christophe, and Cai Wensheng *. Curvature of Buckybowl Corannulene Enhances Its Binding to Proteins. THE JOURNAL OF PHYSICAL CHEMISTRY C, 2018, 123.1: 922-930.

2. Li Meng, Liu Xing-Yu, Feng Xi-Zeng*, Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae, CHEMOSPHERE, 2019, 219: 155-164

3. Mi Ping #, Zhang Qiu Ping #, Li Shi Bao, Liu  Xing-Yu, Zhang Shu-Hui, Li Meng, Chen Dong-Yan*, Zhao Xin*, Feng Dao-Fu*, Feng Xi-Zeng*, Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene‐9‐bisphenol in zebrafish (Danio rerio), JOURNAL OF PINEAL RESEARCH, 2018: e12530

4.Liu Xing-Yu #, Zhang Qiu-Ping #, Li Shi-Bao #, Mi Ping, Chen Dong-Yan*, Zhao Xin*, Feng Xi-Zeng*, Developmental toxicity and neurotoxicity of synthetic organic insecticides in zebrafish (Danio rerio): A comparative study of deltamethrin, acephate, and thiamethoxam, CHEMOSPHERE, 2018, 199: 16-25

5.Jia Zhenzhen #, Feng Zeyang #, Wang Lining, Li Hao, Wang Hongyu, Xu Ding qi, Zhao Xin*, Feng Daofu*, Feng Xizeng*, Resveratrol reverses the adverse effects of diet-induced obese murine model on oocyte quality and zona pellucida softening, FOOD & FUNCTION, 2018, 9 (5): 2623-2633

Papers published in 2017:

1. Li, XY (Li, Xinyu); Sun, DD (Sun, Dandan); Li X (Li, Xu); Zhang, DX (Dashuai); Jao, JJ (Jiao, Jiajia); Wang, K (Wang, Kai); Kong, DL (Kong, Deling); Zhao, X (Zhao, Xin); Xu, L* (Xu, Lin); Zhao, Q* (Zhao, Qing); Chen, DY* (Chen, Dongyan); Feng, XZ* (Feng, Xizeng). PEGylation corannulene enhances response of stress through promoting neurogenesis. BIOMATERIALS SCIENCE, 2017, 5(4): 849-859.

2. Li, XY (Li, Xinyu); Wang, HY (Wang, Hongyu); Kuang, XH (Kuang, Xiangyu); Ma, JR (Ma, Jingrui);Feng, XZ* (Feng, Xizeng). Exploring the effects and mechanisms of carbon nanomaterial diversity on the morphology of lysozyme crystals. CRYSTENGCOMM, 2017, 19(39): 5873-5881.

3. Zhang, SH (Zhang, Shuhui); Xu, J (Xu, Jia);Kuang, XH (Kuang, Xiangyu);  Li, SB (Li, Shibao); Li, X (Li, Xiang); Zhao, X* (Zhao, Xin); Chen, DY* (Chen, Dongyan); Feng, XZ* (Feng, Xizeng). Biological impacts of glyphosate on morphology, embryo biomechanics and larval behavior in zebrafish (Danio rerio). CHEMOSPHERE, 2017, 181: 270-280.

4. Li, X(Li, Xiang);Guo, JYGuo, JY (Guo, Jia-Yu);Li, X (Li, Xu); Zhou, HJ (Zhou Hai-Jun); Zhang,SH (Zhang Shu-Hui); Liu XD (Liu, Xiao-Dong); Chen, DY* (Chen, Dong-yan); Fang, YC*(Fang Yong-Chun);Feng, XZ* (Feng, Xi-Zeng). Behavioural effect of low-dose BPA on male zebrafish: Tuning of male mating competition and female mating preference during courtship process. CHEMOSPHERE, 2017, 169, 40-52.

5. Li, X (Li, Xiang); Zhang, Y (Zhang, Yuan); Li, X (Li, Xu); Feng, DF (Feng, Dao-Fu);Zhang,SH (Zhang Shu-Hui); Zhao, X (Zhao, Xin); Chen, DY* (Chen, Dong-Yan); Zhang, ZX* (Zhang, Zhi-Xiang); Feng, XZ* (Feng, Xi-Zeng). Comparative analysis of biological effect of corannulene and graphene on developmental and sleep/wake profile ofzebrafish larvae. ACTA BIOMATERIALIA, 2017, 55, 271-282.

6. Jia, ZZ (Jia, Zhenzhen); Yang, C (Yang, Cui); Jiao, JJ (Jiao,Jiajia); Li, XY (Li, Xinyu); Zhu, DS (Zhu, Da-shuai); Yang, YC (Yang, Yongchao); Yang, JY (Yang, Jingyi); Che, YZ (Che, Yongzhe); Lu, Y* (Lu, Yun); Feng, XZ* (Feng, Xizeng). Rhein and PDMS functionalized C/C composites as prostheticimplants for bone repair application. BIOMEDICAL MATERIALS, 2017, 12, 045004.

7. Jia, ZZ (Jia, Zhenzhen); Yang, C (Yang, Cui);Jiao, JJ (Jiao,Jiajia);Li, XY (Li, Xinyu); Yang, YC (Yang, Yongchao); Yang, JY (Yang, Jingyi); Geng, XJ (Geng, Xingjie); Lu, Y* (Lu, Yun); Feng, XZ* (Feng, Xizeng). In vitro and in vivo investigation of the effects of polydimethylsiloxane and paeonol modification on the biocompatibility of carbon/carbon composites. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 2017, 4(1), 015010.

Papers published in 2016：

1. Jiao, JJ (Jiao,Jia-Jia); Sun,LL (Sun,Li-Li); Guo, ZY (Guo,Zai-Yu); Hou, S (Hou, Sen);Robert Holyst*; Lu, Y*(Lu, Yun) ; Feng, XZ* (Feng, Xi-Zeng).Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2- hydroxyacetophenone).SCIENTIFIC REPORTS. 2016. 6:38973.

2. Han, GM (Han, Gui-Mei);Jia, ZZ (Jia, Zhen-Zhen); Zhu, YJ (Zhu, Yan-Jun); Jiao,JJ (Jiao, Jia-Jia); Kong, DM* (Kong, De-Ming); Feng, XZ* (Feng, Xi-Zeng).Biostable L-DNA-Templated Aptamer-Silver Nanoclusters for Cell-Type-Specific Imaging at Physiological Temperature. ANALYTICAL CHEMISTRY.2016. 88(22),10800-10804.

3. Li, X (Li, Xiang);Li, X (Li, Xu); Chen, D (Chen, Di);  Guo, JL (Guo, Jia-Liang); Feng, DF (Feng, Dao-Fu); Sun, MZ (Sun, Ming-Zhu); Lu, Y*(Lu, Yun); Chen, DY* (Chen, Dong-Yan); Zhao, X* (Zhao, Xin); Feng, XZ* (Feng, Xi-Zeng).Evaluating the biological impact of polyhydroxyalkanoates (PHAs) on developmental and exploratory profile of zebrafish larvae. RSC ADVANCES. 2016. 6, 37018–37030.

4. Li, X (Li, Xu);Gao AA (Gao, Ai-Ai); Wang, YN (Wang, Ya-Nan); Chen, M (Chen, Man); Peng, J (Peng, Jun); Yan, HY (Yan, Hua-Ying); Zhao, X (Zhao, Xin); Feng, XZ* (Feng, Xi-Zeng); Chen, DY* (Chen, Dong-Yan).Alcohol exposure leads to unrecoverable cardiovascular defects along with edema and motor function changes in developing zebrafish larvae. BIOLOGY OPEN. 2016. 5(8),1128-1133. 

① The course for undergraduate --- Structural Biology

② The course for postgraduate ---Research Progress of Nano Biotechnology