高洁

多肽仿生可控组装用于疾病诊疗

发表通讯/第一作者论文40余篇，包括Chem. Soc. Rev.，J. Am. Chem. Soc. (3)，Adv. Mater. (3)，Angew. Chem. Int. Ed.，Adv. Func. Mater.， Adv. Sci.，Nano Lett.等。申请中国发明专利10项，授权5项，转让2项，申请美国发明专利1项。先后主持科研项目8项。

论文列表：

Sun, X.;  Ren, H.;  Cui, Y.-C.;  Liu, Q.;  Li, J.* and Gao, J.*, Surface-induced self-assembly of peptides turns superhydrophobic surface of electrospun fibrous into superhydrophilic one (paper link). Colloids Surf. B 2025, 245, 114350.

Ma, H.; Xu, L.; Wu, S.; Wang, S.; Li, J.; Ai, S.; Yang, Z.; Mo, R.; Lin, L.; Li, Y.; Wang, S.;Gao J.*; Li C.* and Kong D.*, Supragel-medated efficient generation of pancreatic progenitor clusters and functional glucose-responsive islet-like clusters (paper link). Bioact. Mater. 2024, 41, 1-14.

Zhang, X.; Zhang, B.; Zhang, Y.; Ding, Y.; Zhang, Z.; Liu, Q.; Yang, Z.; Wang, L.* and Gao, J.*, Copper-induced Supramolecular Peptide Assemblies for Multi-pathway Cell Death and Tumor Inhibition (paper link). Angew. Chem. Int. Ed. 2024, e202406602. (Back Cover)

Zheng, D#; Guo J.#, Liu J.; Jin, Y.; Qi, C.; Li, X.; Shi, K.; Ding, Y.; Xie, L.; Wang, L.; Hu, Z.; Yang, Z.; Liu, Q.; Ning, W.* and Gao, J.*, Supramolecular Nanofibers Ameliorate Bleomycin-Induced Pulmonary Fibrosis by Restoring Autophagy (paper link). Adv. Sci. 2024, 2401327.

Cai, X.^#; Cao, J.^#; Wang, L.; Zou, J.; Li, R.; Sun, P.; Ding, X.; Zhang, B.; Liu, Z.; Pei, X.; Yang, J.; Zhan, Y.; Liu, N.; Liu, T.; Liang, R.*; Gao J.*; Wang S.*, Liraglutide Protects Pancreatic Islet From Ischemic Injury by Reducing Oxidative Stress and Activating Akt Signaling During Cold Preservation to Improve Islet Transplantation Outcomes (paper link). Transplantation 2024, 108 (8), e156-e169.

Zhang, X.; Wang, J.; Zhang, Y.; Yang, Z.; Gao, J.*; Gu, Z.*, Synthesizing biomaterials in living organisms (paper link). Chem. Soc. Rev. 2023, 52 (23), 8126-8164. (Front Cover) 

Chen, Y.; Li, W.; Wang, Z.; Yu, Y.; Li, J.; Ding, Y.; Hu, Z.; Liu, Q.; Yang, Z.*; Gao, J.*, A Transformable Supramolecular Bispecific Cell Engager for Augmenting Natural Killer and T Cell-Based Cancer Immunotherapy (paper link). Adv. Mater. 2023, 2306736.

Li, X.^#; Zhang, Y.^#; Wang, Y.; Chen, Y.; Xu, T.; Wang, L.*; Gao, J.*; Yang, Z.*, A blood-brain barrier crossing peptide (paper link). Sci. China. Mater. 2023, 66 (8), 3327-3336. (Front Cover, #equal contribution)

Yang, C.; Mu, G.; Zhang, Y.; Gao, Y.; Zhang, W.; Liu, J.; Zhang, W.; Li, P.; Yang, L.; Yang, Z.; Gao, J.*; Liu, J.*, Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization (paper link). Adv. Mater. 2022, 34, 2202625.

Li, X.; Yu, Z.; Jiang, S.; Dai, X.; Wang, G.; Wang, Y.; Yang, Z.; Gao, J.*; Zou, H.*, An amelogenin-based peptide hydrogel promoted the odontogenic differentiation of human dental pulp cells (paper link). Regen. Biomater. 2022, 9, rbac03

Zhang, Y.; Yu, Y.; Gao, J.*, Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides (paper link). Front. Chem. 2022, 10, 815551.

Li, X.; Wang, Y.; Zhang, Y.; Yang, Z.; Gao, J.*; Shi, Y.*, Enzyme Instructed Self-assembly (EISA) Assists the Self-assembly and Hydrogelation of Hydrophobic Peptides (paper link). J. Mater. Chem. B. 2022, 10 (17), 3242-3247.

Ai, S.; Li, H.; Zheng, H.; Liu, J.; Gao, J.*; Liu, J.*; Chen, Q.*; Yang, Z.*, A SupraGel for efficient production of cell spheroids (paper link). Sci. China Mater. 2022, 65 (6), 1655-1661.

Zheng, D.; Liu, J.; Ding, Y.; Xie, L.; Zhang, Y.; Chen, Y.; Peng, R.; Cai, M.; Wang, L.; Wang, H.*; Gao, J.*; Yang, Z.*, Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude (paper linke). Nanoscale 2021, 13 (24), 10891-10897.

Zhang, Y.; Ding, Y.; Li, X.; Zheng, D.; Gao, J.*; Yang, Z.*, Supramolecular hydrogels of self-assembled zwitterionic-peptides (paper link). Chin. Chem. Lett. 2021.

Shang, Y.; Liu, H.; Peng, R.; Ren, C.; Luo, X.; Ma, C.; Gao, Y.; Wang, Z.; Gao, J.*; Liu, J.*; Yang, Z.*, PDGF-mimicking supramolecular nanofibers for ionizing radiation-induced injury repair (paper link). Chem. Eng. J. 2021, 410, 128309.

Feng, K.; Ma, C.; Liu, Y.; Yang, X.; Yang, Z.; Chen, Y.; Xu, T.; Yang, C.;  Zhang, S.; Li, Q.; Wei, Z.; Zhao, D.; Zeng, P.; Han, J.; Gao, J.*; Chen, Y.*; Duan, Y.*, Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis (paper link). Theranostics 2021, 11 (6), 2634-2654.

Liang, C.; Wang, Z.; Xu, T.; Chen, Y.; Zheng, D.; Zhang, L.; Zhang, W.; Yang, Z.; Shi, Y.*; Gao, J.*, Preorganization Increases the Self-Assembling Ability and Antitumor Efficacy of Peptide Nanomedicine (paper link). ACS Appl. Mater. Interfaces 2020, 12 (20), 22492-22498.

Gao, J.; Gu, Z.*, Toward nanoscopic cellular imaging by X-ray (paper link). Natl. Sci. Rev. 2020, 8 (3), nwaa206.

Shang, Y.; Liao, Y.; Ye, Z. J.; Wang, Z. Y.; Xiao, L.; Gao, J.*; Wang, Q.*; Yang, Z.*, Supramolecular protein glue to boost enzyme activity (paper link). Sci. China Mater. 2019,62 (9), 1341-1349.

Shang, Y.; Zhi, D.;  Feng, G.;  Wang, Z.;  Mao, D.;  Guo, S.;  Liu, R.;  Liu, L.; Zhang, S.; Sun, S.; Wang, K.*; Kong, D.; Gao, J.*; Yang, Z.*, Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor-I (paper link). Nano Lett. 2019, 19 (3), 1560-1569.

Gao, J.; Zhan, J.; Yang, Z.*, Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides (paper link). Adv. Mater. 2019, 0 (0), 1805798.

Zhang, Y.; Pan, Y.-C.; Wang, Y.; Guo, D.-S.*; Gao, J.*; Yang, Z., Fast naked-eye detection of zinc ions by molecular assembly-assisted polymerization of diacetylene (paper link). Nanoscale 2018, 10 (39), 18829-18834.

Li, H.^#; Gao, J.^#; Shang, Y.; Hua, Y.; Ye, M.; Yang, Z.*; Ou, C.*; Chen, M.*, Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction (paper link). ACS Appl. Mater. Interfaces 2018, 10 (29), 24459-24468. (#equal contribution)

Zhan, J.; Cai, Y.; Ji, S.; Shang, Y.; Gao, J.*; Yang, Z.*, Supramolecular silk from a peptide hydrogel (paper link). Mater. Chem. Front. 2017, 1 (5), 911-915.

Wang, Z.; Cai, Y.; Yi, L.; Gao, J.*; Yang, Z.*, Supramolecular Hydrogels of Indole-Capped Short Peptides as Vaccine Adjuvants (paper link). Chin. J. Chem. 2017, 35 (7), 1057-1062.

Chen, G.; Li, J.; Song, M.; Wu, Z.; Zhang, W.; Wang, Z.; Gao, J.*; Yang, Z.*; Ou, C.*, A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction (paper link). Adv. Funct. Mater. 2017, 27 (34), 1701798.

Cai, Y.; Shen, H.; Zhan, J.; Lin, M.; Dai, L.; Ren, C.; Shi, Y.; Liu, J.*; Gao, J.*; Yang, Z.*, Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs (paper link). J. Am. Chem. Soc. 2017, 139 (8), 4.

Wang, J.; Zheng, J.; Cai, Y.; Zheng, J.; Gao, J.*; Gong, Q.*; Yang, Z.*, Imaging cellular distribution of fluorescent supramolecular nanofibers (paper link). Sci. China Chem. 2016, 59 (6), 719-723.

Xu, C.; Cai, Y.; Ren, C.; Gao, J.*; Hao, J.*, Zinc-Triggered Hydrogelation of Self-assembled Small Molecules to Inhibit Bacterial Growth (paper link). Sci. Rep. 2015, 5.

Chen, G.; Chen, J.; Liu, Q.; Ou, C.*; Gao, J.*, Enzymatic formation of a meta-stable supramolecular hydrogel for 3D cell culture (paper link). RSC Adv. 2015, 5 (39), 30675-30678.

Gao, J.; Shi, Y.; Wang, Y.; Cai, Y.; Shen, J.; Kong, D.*; Yang, Z.*, Enzyme-controllable F-NMR turn on through disassembly of peptide-based nanospheres for enzyme detection (paper link). Org. Biomol. Chem. 2014, 12 (9), 1383-1386.

Zheng, W.^#; Gao, J.^#; Song, L.; Chen, C.; Guan, D.; Wang, Z.; Li, Z.*; Kong, D.*; Yang, Z.*, Surface-Induced Hydrogelation Inhibits Platelet Aggregation (paper link). J. Am. Chem. Soc. 2013, 135 (1), 266-271. (#equal contribution)

Gao, J.; Zheng, W.; Zhang, J.; Guan, D.; Yang, Z.*; Kong, D.; Zhao, Q.*, Enzyme-controllable delivery of nitric oxide from a molecular hydrogel (paper link). Chem. Commun. 2013, 49 (80), 9173-9175.

Gao, J.; Zheng, W.; Kong, D.*; Yang, Z.*, Dual enzymes regulate the molecular self-assembly of tetra-peptide derivatives (paper link). Soft Matter 2011, 7 (21), 10443-10448.

Gao, J.; Wang, H.; Wang, L.; Wang, J.; Kong, D.*; Yang, Z.*, Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule (paper link). J. Am. Chem. Soc. 2009, 131 (32), 11286-11287.

中国医药生物技术协会纳米生物技术分会委员，天津市药理学会实验药理专业委员。《Exploration》杂志青年编委； Nano Letters、Bioactive Materials、ACS Nano、Chemical Engineering Journal、Biomaterials、Acta Biomaterialia等国际刊物审稿人。

2021年起主讲一门本科生专业选修课：材料科学与工程

2022年：南开大学“百名青年学科带头人”；

2021年：国家自然科学基金委“优秀青年基金”；

2017年：天津市首批“青年人才托举工程”；

2016年：天津市“131创新型人才计划”；

2014年：天津市自然科学一等奖（第七完成人）。