Jie Gao

Homepage：https://www.x-mol.com/groups/Gao_jie

2004-2008, School of Materials Science and Engineering, Tianjin University, Bachelor of Materials Science.2008-2013，College of Life Sciences, Nankai University，Doctor of Chemisty.

2013-2017, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Assistant Professor. 2017-2022，State Key Laboratory of Medicinal Chemical Biology, Nankai University，Associate Professor. 2019-2020, Department of Bioengineering, UCLA, Visiting Associated Researcher. 2022-present, State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University，Professor.

Her current research interest focuses on the design and fabrication of materials utilizing controlled self-assembly of bioactive peptide as well as exploration of their biomedical applications. Her research group is developing materials from self-assembled peptides for the treatment of ischemic disease and cancers.

She has published more than 40 peer reviewed papers, including J Am. Chem. Soc., Adv. Mater, Angew. Chem. Int. Ed, Nano lett., etc.

Key publication list:

1.     Zhang, X.; Zhang, B.; Zhang, Y.; Ding, Y.; Zhang, Z.; Liu, Q.; Yang, Z.; Wang, L.* and Gao, J.*, Copper-induced Supramolecular Peptide Assemblies for Multi-pathway Cell Death and Tumor Inhibition. Angew. Chem. Int. Ed.2024, In press.

2.      Zheng, D#; Guo J.#, Liu J.; Jin, Y.; Qi, C.; Li, X.; Shi, K.; Ding, Y.; Xie, L.; Wang, L.; Hu, Z.; Yang, Z.; Liu, Q.; Ning, W.* and Gao, J.*, Supramolecular Nanofibers Ameliorate Bleomycin-Induced Pulmonary Fibrosis by Restoring Autophagy. Adv. Sci.2024, 2401327.

3.      Cai, X.^#; Cao, J.^#; Wang, L.; Zou, J.; Li, R.; Sun, P.; Ding, X.; Zhang, B.; Liu, Z.; Pei, X.; Yang, J.; Zhan, Y.; Liu, N.; Liu, T.; Liang, R.*; Gao J.*; Wang S.*, Liraglutide Protects Pancreatic Islet From Ischemic Injury by Reducing Oxidative Stress and Activating Akt Signaling During Cold Preservation to Improve Islet Transplantation Outcomes. Transplantation, 2024. DOI: 10.1097/tp.0000000000004949.

4.       Zhang, X.; Wang, J.; Zhang, Y.; Yang, Z.; Gao, J.*; Gu, Z.*, Synthesizing biomaterials in living organisms. Chem. Soc. Rev.2023, 52 (23), 8126-8164.

5.       Chen, Y.; Li, W.; Wang, Z.; Yu, Y.; Li, J.; Ding, Y.; Hu, Z.; Liu, Q.; Yang, Z.*; Gao, J.*, A Transformable Supramolecular Bispecific Cell Engager for Augmenting Natural Killer and T Cell-Based Cancer Immunotherapy. Adv. Mater.2023, 36 (3), 2306736.

6.        Li, X.^#; Zhang, Y.^#; Wang, Y.; Chen, Y.; Xu, T.; Wang, L.*; Gao, J.*; Yang, Z.*, A blood-brain barrier crossing peptide. Sci. China. Mater. 2023, 66 (8), 3327-3336.

7.      Yang, C.; Mu, G.; Zhang, Y.; Gao, Y.; Zhang, W.; Liu, J.; Zhang, W.; Li, P.; Yang, L.; Yang, Z.; Gao, J.*; Liu, J.*, Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization. Adv. Mater. 2022, 34 (37), 2202625.

8.      Li, X.; Yu, Z.; Jiang, S.; Dai, X.; Wang, G.; Wang, Y.; Yang, Z.; Gao, J.*; Zou, H.*, An amelogenin-based peptide hydrogel promoted the odontogenic differentiation of human dental pulp cells. Regen. Biomater.2022, 9, rbac039.

9.      Zhang, Y.; Yu, Y.; Gao, J.*, Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides. Frontiers in Chemistry2022,10, 815551.

10.     Li, X.; Wang, Y.; Zhang, Y.; Yang, Z.; Gao, J.*; Shi, Y.*, Enzyme Instructed Self-assembly (EISA) Assists the Self-assembly and Hydrogelation of Hydrophobic Peptides. J. Mater. Chem. B. 2022, 10 (17), 3242-3247.

11.    Ai, S.; Li, H.; Zheng, H.; Liu, J.; Gao, J.*; Liu, J.*; Chen, Q.*; Yang, Z.*, A SupraGel for efficient production of cell spheroids. Sci. China Mater.2022, 65 (6), 1655-1661.

12.    Zheng, D.; Liu, J.; Ding, Y.; Xie, L.; Zhang, Y.; Chen, Y.; Peng, R.; Cai, M.; Wang, L.; Wang, H.*; Gao, J.*; Yang, Z.*, Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude. Nanoscale2021,13 (24), 10891-10897.

13.    Zhang, Y.; Ding, Y.; Li, X.; Zheng, D.; Gao, J.*; Yang, Z.*, Supramolecular hydrogels of self-assembled zwitterionic-peptides. Chin. Chem. Lett.2021. 32(11), 3636-3640.

14.     Shang, Y.; Liu, H.; Peng, R.; Ren, C.; Luo, X.; Ma, C.; Gao, Y.; Wang, Z.; Gao, J.*; Liu, J.*; Yang, Z.*, PDGF-mimicking supramolecular nanofibers for ionizing radiation-induced injury repair. Chem. Eng. J.2021,410, 128309.

15.    Feng, K.; Ma, C.; Liu, Y.; Yang, X.; Yang, Z.; Chen, Y.; Xu, T.; Yang, C.;  Zhang, S.; Li, Q.; Wei, Z.; Zhao, D.; Zeng, P.; Han, J.; Gao, J.*; Chen, Y.*; Duan, Y.*, Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis. Theranostics2021,11 (6), 2634-2654.

16.    Liang, C.; Wang, Z.; Xu, T.; Chen, Y.; Zheng, D.; Zhang, L.; Zhang, W.; Yang, Z.; Shi, Y.*; Gao, J.*, Preorganization Increases the Self-Assembling Ability and Antitumor Efficacy of Peptide Nanomedicine. ACS Appl. Mater. Interfaces2020,12 (20), 22492-22498.

17.    Gao, J.; Gu, Z.*, Toward nanoscopic cellular imaging by X-ray. Natl. Sci. Rev. 2020, nwaa206.

18.    Shang, Y.; Liao, Y.; Ye, Z. J.; Wang, Z. Y.; Xiao, L.; Gao, J.*; Wang, Q.*; Yang, Z.*, Supramolecular protein glue to boost enzyme activity. Sci. China Mater.2019,62 (9), 1341-1349.

19.    Shang, Y.; Zhi, D.; Feng, G.; Wang, Z.; Mao, D.; Guo, S.; Liu, R.; Liu, L.; Zhang, S.; Sun, S.; Wang, K.*; Kong, D.; Gao, J.*; Yang, Z.*, Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor-I. Nano Lett.2019,19 (3), 1560-1569.

20.    Gao, J.; Zhan, J.; Yang, Z.*, Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides. Adv. Mater.2019,0 (0), 1805798.

21.    Zhang, Y.; Pan, Y.-C.; Wang, Y.; Guo, D.-S.*; Gao, J.*; Yang, Z., Fast naked-eye detection of zinc ions by molecular assembly-assisted polymerization of diacetylene. Nanoscale2018,10 (39), 18829-18834.

22.    Li, H.^#; Gao, J.^#; Shang, Y.; Hua, Y.; Ye, M.; Yang, Z.*; Ou, C.*; Chen, M.*, Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction. ACS Appl. Mater. Interfaces2018,10 (29), 24459-24468. (#equal contribution)

23.    Zhan, J.; Cai, Y.; Ji, S.; Shang, Y.; Gao, J.*; Yang, Z.*, Supramolecular silk from a peptide hydrogel. Mater. Chem. Front.2017,1 (5), 911-915.

24.    Wang, Z.; Cai, Y.; Yi, L.; Gao, J.*; Yang, Z.*, Supramolecular Hydrogels of Indole-Capped Short Peptides as Vaccine Adjuvants. Chin. J. Chem.2017,35 (7), 1057-1062.

25.    Chen, G.; Li, J.; Song, M.; Wu, Z.; Zhang, W.; Wang, Z.; Gao, J.*; Yang, Z.*; Ou, C.*, A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction. Adv. Funct. Mater.2017,27 (34), 1701798.

26.    Cai, Y.; Shen, H.; Zhan, J.; Lin, M.; Dai, L.; Ren, C.; Shi, Y.; Liu, J.*; Gao, J.*; Yang, Z.*, Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs. J. Am. Chem. Soc.2017,139 (8), 4.

27.    Wang, J.; Zheng, J.; Cai, Y.; Zheng, J.; Gao, J.*; Gong, Q.*; Yang, Z.*, Imaging cellular distribution of fluorescent supramolecular nanofibers. Sci. China Chem.2016,59 (6), 719-723.

28.    Xu, C.; Cai, Y.; Ren, C.; Gao, J.*; Hao, J.*, Zinc-Triggered Hydrogelation of Self-assembled Small Molecules to Inhibit Bacterial Growth. Sci. Rep.2015,5.

29.    Chen, G.; Chen, J.; Liu, Q.; Ou, C.*; Gao, J.*, Enzymatic formation of a meta-stable supramolecular hydrogel for 3D cell culture. RSC Adv.2015,5 (39), 30675-30678.

30.    Gao, J.; Shi, Y.; Wang, Y.; Cai, Y.; Shen, J.; Kong, D.*; Yang, Z.*, Enzyme-controllable F-NMR turn on through disassembly of peptide-based nanospheres for enzyme detection. Org. Biomol. Chem.2014,12 (9), 1383-1386.

31.    Zheng, W.^#; Gao, J.^#; Song, L.; Chen, C.; Guan, D.; Wang, Z.; Li, Z.*; Kong, D.*; Yang, Z.*, Surface-Induced Hydrogelation Inhibits Platelet Aggregation. J. Am. Chem. Soc.2013,135 (1), 266-271. (#equal contribution)

32.    Gao, J.; Zheng, W.; Zhang, J.; Guan, D.; Yang, Z.*; Kong, D.; Zhao, Q.*, Enzyme-controllable delivery of nitric oxide from a molecular hydrogel. Chem. Commun.2013,49 (80), 9173-9175.

33.     Gao, J.; Zheng, W.; Kong, D.*; Yang, Z.*, Dual enzymes regulate the molecular self-assembly of tetra-peptide derivatives. Soft Matter2011,7 (21), 10443-10448.

34.    Gao, J.; Wang, H.; Wang, L.; Wang, J.; Kong, D.*; Yang, Z.*, Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule. J. Am. Chem. Soc.2009,131 (32), 11286-11287.

Teaching "Materials Science and Engineering" since 2021.

Young Elite Scientists Sponsorship Program by Tianjin, 2017.

National Science Found for Outstanding Young Scholars, 2021.