高金珉

2005年本科毕业于南开大学生命科学学院，2010年获得南开大学遗传学博士学位。2010年加入哈佛大学医学院Colaiacovo教授实验室进行博士后训练，以秀丽隐杆线虫为模式生物研究减数分裂。2017年回国开展科研工作，2018年获评山东省泰山学者青年专家，2020年获得国家自然科学基金优秀青年基金资助。以第一作者或通讯作者在J Cell Biol、Cell Death Differ、Sci Adv、EMBO Rep、J Genet Genomics、Genes Dev、PLoS Genet、Blood、PNAS、J Biol Chem等期刊上发表一系列研究论文。目前围绕着减数分裂的调控机制开展研究工作，并探讨人类基因变异及环境因素对生殖的影响。

2001-2005    南开大学生命科学学院    生物科学专业    本科
2005-2010    南开大学生命科学学院    遗传学专业    博士

2010-2017    哈佛大学医学院遗传系    博士后
2017-2023    山东师范大学生命科学学院    教授
2023--至今    南开大学生命科学学院    教授

有性生殖生物利用减数分裂这一特殊的细胞分裂方式来产生染色体数目减半的配子，实现遗传信息的传递。减数分裂染色体的精确分离依赖于一系列减数分裂特有的事件，这些事件的调控异常可导致非整倍体的产生，是导致唐氏综合征等出生缺陷以及不育、流产等人类疾病的重要因素。我们以秀丽隐杆线虫为主要的体内研究模型，探讨减数分裂特有细胞结构的组装和调控机制，致力于阐明导致减数分裂染色体分离异常的内外源因素。

通讯作者论文（唯一通讯/末位通讯）

1.  R. Wang et al., A DNA-containing phase-separated compartment links the nuclear envelope to chromosome axes to promote homolog pairing in C. elegans. Sci Adv 11, eadw5764 (2025).

2.  F. Qi et al., Dynamic SAS-6 phosphorylation aids centrosome duplication and elimination in C. elegans oogenesis. EMBO Rep 26, 3411-3444 (2025).

3.  Y. Liu et al., Cohesin variants and meiotic timing shape chromosome segregation accuracy. J Genet Genomics, S1673-8527 (2025).

4.  Y. Liu et al., Cohesin ring gates are specialized for meiotic cell division. J Mol Cell Biol 16, mjae047 (2025).

5.  R. Zhang et al., A chromosome-coupled ubiquitin-proteasome pathway is required for meiotic surveillance. Cell Death Differ 31, 1730-1745 (2024).

6.  R. Wang et al., The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans. J Cell Biol 223,  (2024).

7.  Y. Liu, J. Gao, Reproductive aging: biological pathways and potential interventive strategies. J Genet Genomics 50, 141-150 (2023).

8.  R. Zhang, Y. Liu, J. Gao, Phase separation in controlling meiotic chromosome dynamics. Curr Top Dev Biol 151, 69-90 (2023).

9.  F. Zhang, M. Liu, J. Gao, Alterations in synaptonemal complex coding genes and human infertility. Int J Biol Sci 18, 1933-1943 (2022).

10.  Y. Liu et al., SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans. J Mol Cell Biol 13, 662-675 (2021).

11.  F. Zhang, R. Zhang, J. Gao, The organization, regulation, and biological functions of the synaptonemal complex. Asian J Androl 23, 580-589 (2021).

12.  Z. Zhang et al., Multivalent weak interactions between assembly units drive synaptonemal complex formation. J Cell Biol 219, e201910086 (2020). 封面文章

 

第一作者论文（含共同）

1.  J. Gao, M. P. Colaiacovo, Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics. Trends Genet 34, 232-245 (2018).

2.  J. Gao et al., N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev 30, 2404-2416 (2016). 封面文章

3.  J. Gao et al., NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. PLoS Genet 11, e1005029 (2015).

4.  J. Gao et al., CYLD regulates angiogenesis by mediating vascular endothelial cell migration. Blood 115, 4130-4137 (2010).

5.  L. Sun et al., Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B. J Pathol 221, 425-432 (2010).

6.  L. Sun et al., EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Proc Natl Acad Sci U S A 105, 7153-7158 (2008).

7.   J. Gao et al., The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration. J Biol Chem 283, 8802-8809 (2008).

 

部分合作论文

1.  Q. Shao et al., ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis. Cell reports 42, 112953 (2023).

2.  B. Zhai et al., Dna2 removes toxic ssDNA-RPA filaments generated from meiotic recombination-associated DNA synthesis. Nucleic Acids Res 51, 7914-7935 (2023).

3.  T. Tan et al., Negative supercoils regulate meiotic crossover patterns in budding yeast. Nucleic Acids Res 50, 10418-10435 (2022).

4.  H. Ma et al., NuMA forms condensates through phase separation to drive spindle pole assembly. J Mol Cell Biol 14,  (2022).

5.  J. Ran et al., ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Dev Cell 53, 287-299 e285 (2020).

6.  Y. B. Tzur et al., Spatiotemporal Gene Expression Analysis of the Caenorhabditis elegans Germline Uncovers a Syncytial Expression Switch. Genetics 210, 587-605 (2018).

中国遗传学会青年工作委员会委员

中国细胞生物学学会青年工作委员会委员

中国细胞生物学学会细胞结构与细胞行为分会委员会委员

中国细胞生物学学会生殖细胞生物学分会委员

山东省细胞生物学学会常务理事

本科生《遗传学》

2018年获评山东省泰山学者青年专家

2020年获国家自然科学基金优秀青年基金资助

2022年获评山东省青年科技奖