Huangxinglu

Xinglu Huang, Ph.D, is a professor of College of Life Science with joint appointment in State Key Laboratory of Medicinal Chemical Biology at Nankai University. Following his Ph.D degree received from Chinese Academy of Science in 2010, he moved to US and completed his postdoctoral training in National Institutes of Health (Advisor: Shawn Chen) and Johns Hopkins School of Medicine (Advisor: Justin Hanes), respectively. After that, he started his faculty at Nankai University in 2018. He has been elected as “Nankai Hundreds of Young Academic Leader”at Nankai University. His research interests are 1) tumor diagnose and therapy; 2) tissue engineering and regenerative medicine.

His research interests mainly include biomedicine, chemistry, materials and tissue engineering as below.

(1) Biological effect of nanoparticles: interaction of nanoparticle and biological barriers; bioactive nanomaterials for active modulation of disease treatment; interaction of bioactive nanomaterials and tissue ischemia and its applications.

(2) Tumor theranostics: design and development of nanoprobe and/or nanomedicine for tumor imaging and/or therapy.

(3) Tissue engineering and regenerative medicine: bioactive nanomaterials for vascularization, damage and regeneration of ischemic tissues; nanosized stem cells for tissue regeneration.

Until now, he has published more than 40 research papers, with citation of >2800 and H-index of 28. Among them, his first/corresponding authored papers includes PNAS, Nature Protocols, J Am Chem Soc, ACS Nano, Angewandte Chemie, Biomaterials and Theranostics.

Selected publications:

1.Huang X, Chisholm J, Zhuang J, Xiao Y, Parikh K, Zhang C, Chen X, Suk JS, Hanes J. Protein Nanocages that penetrate airway mucus and tumor tissue. PNAS. 2017, 114(32): E6595-E6602.

2. Huang X,* Zhang F,* Wang Y, Sun X, Choi KY, Liu D, Cheon J, Niu G, Chen X. Design Consideration of Iron-based Nanoclusters for Non-invasive Tracking Mesenchymal Stem Cell Homing. ACS Nano. 2014, 8(5):4403-14. (*Equally contributed)

3. Choi KY,* Silvestre OF,* Huang X,* Hida N, Liu G, Ho DN, Lee S, Lee SW, Hong JI, Chen X. A Nanoparticle Formula for Delivering siRNA or miRNAs to Tumor Cells in Cell Culture and in vivo. Nature Protoc. 2014, 9(8):1900-15. (*Equally contributed)

4. Sun X,* Huang X,* Guo J, Niu G, Zhu W, Kiesewetter DO, Sun S, Chen X. Self-illuminating 64Cu Doped CdSe/ZnS QDs for In Vivo Tumor Imaging. J Am Chem Soc. 2014, 136(5):1706-9. (*Equally contributed)

5. Huang X, Zhang F, Sun X, Choi KY, Niu G, Zhang G, Guo J, Lee S, Chen X. The Genotype-dependent Influence of Functionalized Multiwalled Carbon Nanotubes on Fetal Development. Biomaterials. 2014, 35(2): 856-865.

6. Huang X,Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun Y, Lee S, Chen X. Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots. ACS Nano. 2013, 7(7):5684-93.

7. He J,* Huang X,* Li YC, Liu Y, Babu T, Aronova MA, Wang S, Lu Z, Chen X, Nie Z. Self-Assembly of Amphiphilic Plasmonic Micelle-Like Nanoparticles in Selective Solvents. J Am Chem Soc. 2013, 135(21): 7974-7984. (*Equally contributed)

8. Huang X,Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X. Mesenchymal Stem Cell-based Cell Engineering with Multifunctional Mesoporous Silica Nanoparticles for Tumor Delivery. Biomaterials. 2013, 34(7):1772-80.

9. Zhang F,* Huang X,*Zhu L, Guo N, Niu G, Swierczewska M, Lee S, Xu H, Wang AY, Mohamedali KA, Rosenblum MG, Lu G, Chen X. Noninvasive Monitoring of Orthotopic Glioblastoma Therapy Response using RGD-conjugated Iron Oxide Nanoparticles. Biomaterials. 2012, 33(21):5414-22. (*equally contributed)

10. Huang X,* Zhang F,* Lee S, Swierczewska M, Kiesewetter D, Lang L, Zhang G, Zhu L, Gao H, Leapman R, Niu G, Chen X. Long-term Multimodal Imaging of Tumor Draining Sentinel Lymph Nodes using Mesoporous Silica-based Nanoprobes. Biomaterials. 2012, 33(17):4370-8. (*Equally contributed)

11. Zhu L,* Huang X,*Choi KY, Ma Y, Zhang F, Liu G, Lee S, Chen X. Real-time Monitoring of Caspase Cascade Activation in Living Cells. J Control Release. 2012, 163(1):55-62. (*equally contributed)

12. Huang X,Swierczewska M, Choi K, Zhu L, Bhirde A, Park J, Kim K, Xie J, Niu G, Lee K, Lee S, Chen X. Multiplex Imaging of Intracellular Proteolytic Cascade Using a Broad Spectrum Nano-Quencher. Angew Chem Int Ed Engl. 2012, 51(7):1625-30.

13. Huang X,*Li L,* Liu T, Hao N, Liu H, Chen D, Tang F. The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance and Biocompatibility in vivo. ACS Nano. 2011, 5(7):5390-9. (*Equally contributed)

14. Huang X, Zhuang J, Teng X, Li L, Chen D, Yan X, Tang F. The Promotion of Human Malignant Melanoma Growth by Mesoporous Silica Nanoparticles through Decreasing Reactive Oxygen Species. Biomaterials. 2010, 31:6142-6153.

15. Huang X,Teng X, Chen D, Tang F, He J. The Effect of the Shape of Mesoporous Silica Nanoparticles on Cellular Uptake and Cell Function. Biomaterials. 2010, 31:438–448.

 "Nankai Hundreds of Young Academic Leader"at Nankai University