靳永新

靳永新，女，博士，副教授。2002-2006年于南开大学生命科学学院攻读学士学位。2006-2011年于南开大学生命科学学院微生物学专业免试攻读博士学位，期间于2009-2011年赴美国佛罗里达大学进行联合培养。2011年开始在南开大学生命科学学院微生物系工作，2016年底晋升为副教授，主要研究致病菌的毒力因子及耐药性相关基因调控。先后主持天津市自然科学基金三项，国家自然科学基金一项。作为第一作者或通讯作者在Advanced Science, PLos Pathogens, mBio, Molecular Microbiology等期刊上发表文章。

2002 南开大学 学士2006 南开大学 博士2009--2011 美国佛罗里达大学 联合培养博士

2011--2016 南开大学生命科学学院 讲师2016-- 南开大学生命科学学院 副教授

■ 致病菌毒性基因的表达调控及作用机制
■ 致病菌耐药机理研究

1.      Wang L, Shen C, Yin L, Zhang Y, Zhang L, Liu S, Cheng Z, Wu W, Ha U-H, Jin S, Jin Y*. PA5201 represses type III secretion system by binding to the PexsC promoter in Pseudomonas aeruginosa，Microbiol Spectr., Accepted.

2.      Bai Y, Zhao Y, Yuan Y, Bai F, Cheng Z, Wu W, Ha U-H, Jin S, Jin Y*. Direct interaction between phosphotransferase LpxT and ArnT modulates polymyxin B resistance in Pseudomonas aeruginosa, Microbiol Spectr., 2026: e0185225.

3.      Shen C, Wang L, Zhang Y, Zhang L, Cheng Z, Wu W, Ha U-H, Jin S, Jin Y*. Pseudomonas aeruginosa tRNA nucleotidyltransferase Cca controls resistance and tolerance to aminoglycoside antibiotics by regulating the MexXY multidrug efflux pump, Antimicrob Agents Chemother., 2026: e0165325.

4.      Zhang Y^#, Yin L^#, Liu Q^#, Wang L, Shen C, Bian Y, Ma Z, Ha U-H, Cheng Z, Wu W, Jin S, Jin Y*. Plasmid replication initiator protein TrfA represses the host type III secretion system in Pseudomonas aeruginosa, mBio, 2025, 16(12): e0278425.

5.      Li X, Liu D, Han S, Liu Y, Fan Y, Zhang Y, Li C, Xia Z, Cui L, Cui J, Wen J*, Yan T, Jiang C, Jin Y*, Ren Q*, Liu M*. Cu₇S₄ Nanozyme Efficiently Inactivating Drug-Resistant Bacteria on Mouse Wound Models through Photodynamic and Photothermal Synergetic Therapy, Adv Sci (Weinh), 2025, 12(33): e03793.

6.      Yin L, Liu Q, Pan X, Lv C, Bai Y, Bai F, Cheng Z, Wu W, Ha UH, Jin Y*. MvaT binds to the P _exsC promoter to repress the type III secretion system in Pseudomonas aeruginosa,Front Cell Infect Microbiol., 2023,13:1267748.

7.      Yang F, Zhou Y, Bai Y, Pan X, Ha UH, Cheng Z, Wu W, Jin Y*, Bai F*. MvfR controls tolerance to polymyxin B by regulating rfaD in Pseudomonasaeruginosa, Microbiol Spectr. 2023, 11(3): e0042623.

8.       Wang D, Zhang X, Yin L, Liu Q, Yu Z, Xu C, Ma Z, Xia Y, Shi J, Gong Y, Bai F, Cheng Z, Wu W, Lin J, Jin Y*. RplI interacts with 5' UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa, PLoS Pathog., 2022, 18(1): e1010170.

9.       Liu Q, Yin L, Lv C, Bai F, Cheng Z, Wu W, Jin Y*. Parallel Evolution to Elucidate the Contributions of PA0625 and parE to Ciprofloxacin Sensitivity in Pseudomonas aeruginosa. Microorganisms, 2022 Dec 21;11(1):13.

10.   Liu Q, Yin L, Zhang X, Zhu G, Liu H, Bai F, Cheng Z, Wu W, Jin Y*. Reversion of Ceftazidime Resistance in Pseudomonas aeruginosa under Clinical Setting.Microorganisms, 2022 Dec 2;10(12):2395

11.   Zhang X, Yin L, Liu Q, Wang D, Xu C, Pan X, Bai F, Cheng Z, Wu W, Jin Y*. NrtR Mediated Regulation of H1-T6SS in Pseudomonas aeruginosa. Microbiol Spectr., 2022, 10(1): e0185821.

12.   Ma Z^#, Xu C^#, Zhang X, Wang D, Pan X, Liu H, Zhu G, Bai F, Cheng Z, Wu W, Jin Y*. A MexR Mutation Which Confers Aztreonam Resistance to Pseudomonas aeruginosa. Front Microbiol. 2021, 12: 659808

13.   Xu C^#, Liu H^#, Pan X, Ma Z, Wang D, Zhang X, Zhu G, Bai F, Cheng Z, Wu W, Jin Y*. Mechanisms for Development of Ciprofloxacin Resistance in a Clinical Isolate of Pseudomonas aeruginosa, Front Microbiol., 2021, 11: 598291.

14.   Xu C, Wang D, Zhang X, Liu H, Zhu G, Wang T, Cheng Z, Wu W, Bai F*, Jin Y*. Mechanisms for rapid evolution of carbapenem resistance in a clinical isolate of Pseudomonas aeruginosa. Front Microbiol., 2020, 11: 1390.

15.   Jin Y^#, Zhang M^#, Zhu F, Peng Q, Weng Y, Zhao Q, Liu C, Bai F, Cheng Z, Jin S*, Wu W*. NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa, Front Microbiol., 2019, 10: 85.

16.   Jin Y^#, Liu Y^#, Li Z, Santostefano K, Shi J, Zhang X, Wu D, Cheng Z, Wu W, Terada N, Jin S*, Bai F*. Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery. PLoS ONE, 2018, 13(3): e0194895.

17.   Tan H, Zhang L, Zhao Q, Chen R, Liu C, Weng Y, Peng Q, Bai F, Cheng Z, Jin S, Wu W, Jin Y*. DeaD contributes to Pseudomonas aeruginosa virulence in a mouse acute pneumonia model. FEMS Microbiol Lett. 2016 Oct;363(20): fnw227.

1. 自2012年起，承担本科生《微生物学实验》（分别为普通班，伯芩班和药学院授课）；

2. 自2014年起，承担本科生《生物技术综合实验》；

3. 自2014年起，承担部分研究生课程《微生物学前沿进展》；

4. 自2018年起，承担本科生《生物科学综合实验》。