龙加福

龙加福，生物化学与分子生物学系系主任，药物化学生物学国家重点实验室固定PI，教育部新世纪优秀人才，第十三届天津青年科技奖获得者。1999年06月获南开大学生物化学学士学位，2004年08月获香港科技大学生物化学博士学位，2004年09月在香港科技大学开始博士后训练。博士学位及博士后研究都是在张明杰院士的指导下完成。研究方向为基因表达调控与疾病。先后主持和参加973课题、国家或天津市及深圳市自然科学基金等16项。在Nat Commun、Nat Struct Mol Biol、PNAS、Cell Res、Cell Discovery、Angew Chem Int Ed、Nucleic Acids Res、Structure、JMB和JBC等国际知名杂志上发表论文57篇，总引用次数超过2740次。多次受邀在国内外学术会议上作报告，担任Nat Struct Mol Biol、Nat Commun、eLife、Advanced Science、Nucleic Acids Res等杂志的审稿人。

1. 1995年9月-1999年6月 南开大学生命科学学院生物化学与分子生物专业，本科，获学士学位；2. 1999年9月-2004年8月 香港科技大学生物化学系，研究生，获博士学位。

1. 2004年8月-2006年12月 香港科技大学生物化学系博士后；2. 2006年12月-至今 南开大学生命科学学院校特聘教授、博士生导师。3. 2020年2月-2021年1月 美国康奈尔大学访问教授（“唐氏.康奈尔-中国”学者）

基因表达调控与疾病
1. 组蛋白修饰复合物的装配机理
2. 染色质变构的调节机制
3. 与人类重大疾病相关蛋白的作用机理

SELECTED PUBLICATIONS: (listed the first or corresponding author only)

1. “Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95”, Long, J., Tochio, H., Wang, P., Fan J.-S,. Sala, C., niethammer, M., Sheng, M. and Zhang, M., J. Mol. Biol., 327(1): 203-214 (2003).

2. “The tetrameric L27 domain complex as an organization platform for supramolecular assemblies”, Feng, W.^&,Long, J.^&(equal contribution), Fan, J,-S., Suetake, T., Zhang, M., Nat. Struct. Mol. Biol., 11(5):475-480 (2004).

3. 'A  unified assembly mode revealed by the structures of tetrameric L27  domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold  proteins”, Feng, W.^&, Long, J.^&(equal contribution), Zhang, M.,Proc. Natl. Acad. Sci. USA, 102(19): 6861-6866 (2005).

4. “Autoinhibition of X11/Mint Scaffold Proteins Revealed by the Closed Conformation of the PDZ Tandem”, Long, J., Feng, W., Wang, R., Chan, L.-N., Fanny, Ip. Xia, J., Nancy, Ip. Zhang, M., Nat. Struct. Mol. Biol., 12(8): 722-728 (2005).

5. “Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1”, Long, J., Wei, Z., Feng, W., Yu, C., Zhao, Y. –X., Zhang, M., J. Mol. Biol., 375(5):1457-1468 (2008).

6. “Structural basis of b-catenin Recognition by Tax-interaction Protein-1”, Zhang, J., Yan, X., Shi, C., Yang, X., Guo, Y., Tian, C., Long, J.*, Shen, Y.*, J. Mol. Biol., 384(1): 255-263 (2008). (*: Co-corresponding author).

7.  “Molecular Mechanism of Inward Rectifier Potassium Channel 2.3  Regulation by Tax-interacting Protein-1”, Yan, X., Zhou, H., Zhang, J.,  Shi, C., Xie, X., Wu, Y., Tian, C., Shen, Y.*, Long, J.*, J. Mol. Biol., 392(4): 967-976 (2009).

8. “Structural  basis for tandem L27 domain-mediated polymerization”, Yang, X., Xie,  X., Chen, L., Zhou, H., Wang, Z., Zhao, W., Tian, R., Zhang, R., Tian,  C., Long. J.*, Shen, Y.*, FASEB J., 24(12): 4806-4815 (2010).

9.  “The structural basis for the oligomerization of the N-terminal domain  of SATB1”, Wang, Z., Yang, X., Chu, X., Zhang, J., Zhou, H., Shen, Y.*, Long, J.*, Nucleic Acids Res., 40(9): 4193-4202 (2012).

10.  “Structure of an L27 domain heterotrimer from the cell polarity complex  Patj/Pals1/Mals2 reveals a mutually independent L27 domain assembly  mode”, Zhang, J., Yang, X., Wang, Z., Zhou, H., Xie, X., Shen, Y.*, Long, J.*, J. Biol. Chem., 287(14): 11132-11140 (2012).

11.  “Rational design of a tetrameric Protein to enhance interactions  between self-assembled fibers confers molecular hydrogels”, Zhang, X.,  Chu, X., Wang, L., Wang, H., Liang, G., Zhang, J., Long, J.*, Yang, Z.*, Angew. Chem. Int. Ed., 51(18): 4388-4392 (2012).

12. “Crystal structure of Elongator subcomplex Elp4-6”, Lin, Z., Zhao, W., Diao, W., Xie, X., Wang, Z., Zhang, J., Shen, Y.*, Long, J.*, J. Biol. Chem.287(25): 21501-21508 (2012).

13. “Open-closed mechanism of Mint2 regulates APP metabolism”, Xie, X., Yan, X., Wang, Z., Zhou, H., Diao, W., Zhou, W., Long, J.*, Shen, Y.*, J. Mol. Cell Biol., 5(1): 48-56 (2013).

14.  “Multifunctional biohybrid hydrogels for cell culture and cotrolled  drug release”, Wang, H., Han, A., Cai, Y., Xie, Y., Zhou, H.*, Long, J.*, Yang, Z.*, Chem. Commun.., 49(67): 7448-7450 (2013).

15. “Growth stimulation of bacterium Delftia by a peptide hydrogel”, Du, X., Wu, Z.,Long, J.*, Wang, L.*, RSC Adv., 3(40): 18259-18262 (2013).

16.  “Structural insights into Paf1 complex assembly and histone binding”,  Chu, X., Qin, X., Xu, H., Li, L., Wang, Z., Li, F., Xie, X., Zhou, H.,  Shen Y.*, Long, J.*, Nucleic Acids Res., 41(22): 10619-10629 (2013).

17.  “Rational design of multifunctional hetero-hexameric proteins for  hydrogel formation and controlled delivery of bioactive molecules”,  Zhang, X., Zhou, H., Xie, Y., Ren, C., Ding, D.*, Long, J.*, Yang, Z.*, Adv. Healthc. Mater., 3(11): 1804-1811 (2014).

18.  “Crystal structure of the Ubiquitin-like domain-CUT repeat-like tandem  of special AT-rich sequence binding protein 1 (SATB1) reveals a  coordinating DNA-binding mechanism”, Wang, Z., Yang, X., Guo, S., Yang,  Y., Su, X-C., Shen, Y.*, Long, J.*, J. Biol. Chem., 289(40): 27376-27385 (2014).

19. “A genetically modified protein-based hydrogel for 3D culture of AD293 cells”, Du, X., Wang, J., Diao, W., Wang, L., Long, J.*, Zhou, H.*, PLoS One, 9(9): e107949 (2014).

20.“The Elp2 subunit is essential for Elongator assembly and functional regulation”, Dong, C., Lin, Z., Diao, W., Li, D., Chu, X., Wang, Z., Zhou, H., Xie, Z., Shen, Y.*, Long, J.*, Structure, 23(6): 1078-1086(2015).

21. “Angiomotin binding-induced activation of Merlin/NF2 in the hippo signaling pathway”, Li, Y., Zhou, H., Li, F., Chan, S., Lin, Z., Wei, Z., Yang, Z., Guo, F., Lim, C., Xing, W., Shen, Y., Hong, W., Long, J.*, Zhang, M.*, Cell Res., 25(7): 801-817 (2015).

22. “Dimerization of elongator protein 1 is essential for Elongator complex assembly”, Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Zhou, H., Xie, X., Wang, Z., Shen, Y.*, Long, J.*, Proc. Natl. Acad. Sci. USA, 112(34): 10697-10702 (2015).

23. “Self-assembly molecular chaperone to concurrently inhibit the production and aggregation of amyloid b peptide associated with Alzheimer's disease”, Hang, F., Qu A., Yang H., Zhu L., Zhou, H., Liu J., Long J.*, and Shi L.*, Acs Macro lett., 7: 983-989 (2018).

24. “Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation”, Xie Y., Zheng M., Chu X., Chen Y., Xu H., Wang J., Zhou, H.*, Long J.*, Nat. Commun., 9(1): 3795 (2018). 

25.“ Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies”, Zhao Y., Liu Z., Wang X., Wu H., Zhang J., Yang J., Zhang F., Liu L.,Long J.*, Lu P.*, Chen Z.*, Clin Cancer Res., 25(18): 5595-5607 (2019).

26. “A Heterotrimeric SMARCB1-SMARCC2 Subcomplex is Required for the Assembly and Tumor Suppression Function of the BAF Chromatin-remodeling Complex”, Chen, G., Zhou, H.*, Liu, B., Wang, Y., Zhao, J., Giancotti, F.*, Long, J.*, Cell Discov., 6:66, (2020). 

27. “Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated monouqbiquitnation”, Chen, F., Liu, B., Guo, L., Ge, X., Feng, W., Li, D-F*, Zhou, H.*, Long, J.*, Proc. Natl. Acad. Sce. USA, 188(33): e2025291118 (2021).

28. “Crystal structure of the core module of the yeast Paf1 complex”, Chen, F., Liu, B., Zeng, J., Guo, L., Ge, X., Feng, W., Li, D-F*, Zhou, H.*, Long, J.*, J Mol Biol, 434(2):167369 (2022).

29.'Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic synovial sarcomas', Cheng, Y., Shen, Z., Gao, Y., Chen, F., Xu, H., Mo, Q., Chu, X., Peng, C-L., Mckenzie, T., Palacios, B., Hu, J., Zhou, H.*, Long, J.*, Nat. Commun., 13(1): 2724 (2022).

30. 'The Paf1 complex is required for RNA polymerase II removal in response to DNA damage', Chen, F., Liu, B., Zhou, H., Long, J.*, Proc. Natl. Acad. Sce. USA, 119(40): e2207332119 (2022).

1. 生物化学（化学伯苓班）

2. 结构生物学导论

3. 蛋白质功能与研究技术

1. 2007年 教育部新世纪优秀人才

2. 2014年 天津市自然科学一等奖（第五完成人）“超分子水凝胶的制备及生物医疗应用”

3. 2015年 第十三届天津青年科技奖

4. 2016年 入选“南开大学2015年度十大科技进展”项目

5. 2016年 第七届赛诺菲-Cell Research优秀论文奖