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刘林

招生专业: 细胞生物学

电话: 23500752

邮箱: liulin@nankai.edu.cn

办公地点: 生物站C301

个人资料

  • 性别:
  • 部门: 遗传学与细胞生物学系
  • 联系电话: 23500752
  • 通讯地址: 天津市南开区卫津路南开大学生物站C301
  • 职称: 教授
  • 电子邮箱: liulin@nankai.edu.cn
  • 办公地址: 生物站C301

教育经历

1980-1984 江西农业大学,动物科学与动物医学,学士 1984-1987 江西农业大学,动物生理学与生物化学,硕士 1990-1993 中国农业大学,生殖生理学与生物技术,博士

工作经历

1987-1990 江西农业大学,助教 1993-1996 中国农业大学,讲师 1994-1996 英国剑桥Babraham研究所,访问学者 1996-1998 美国康奈尔大学、康州大学,博士后 1998-2004 美国布朗大学,助理教授 2003-2007 中山大学,特聘教授 2007-至今 南开大学,特聘教授

个人简介

刘林,博士,南开大学教授,教育部“长江学者”奖励计划特聘教授,国家杰出青年基金获得者,国家百千万人才工程“有突出贡献中青年专家”,天津市“干细胞与再生医学”创新团队带头人。主持了多项国家级重大项目,包括国家重点研究计划项目、国家重大科学研究计划项目、国家重大转基因专项项目、国家国际科技合作专项项目、国家自然科学基金委重点及重大研究计划项目等。获得多项奖励,包括美国生殖医学会辅助生殖技术奖和教育部高等学校科技进步二等奖,广东省科学技术二等奖。担任多个国际科技期刊编委和审稿人。在包括Nature Cell Biology, Nature Biotechnology, Nature, Nature Communications, Developmental Cell, PNAS, Nucleic Acids Research, Human Reproduction, Biology of Reproduction等SCI杂志发表论文130余篇。主要研究方向为1.端粒和异染色质在多能性干细胞多能性及在体细胞重编程、肿瘤发生和复发中的作用及调节机制;2.卵巢衰老机制及抗卵巢衰老的新策略。

研究方向


1端粒和异染色质在多能性干细胞多能性及在体细胞重编程、肿瘤发生和复发中的作用及调节机制。

  

2卵巢衰老机制及抗卵巢衰老的新策略。


科研成果

代表性论文:

1. Guo RP, Ye XY, Yang J, Zhou ZC, Tian CL, Wang H, Wang HY, Fu HF, Liu C, Zeng M, Yang J & Liu L. Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nature Communications. 9(1):2620 (2018).

2. Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, Chen L, Liu L. Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 46(7):3468-3486(2018).

3. Fu H, Tian CL, Ye X, Sheng X, Wang H, Liu Y, Liu L. Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells. Stem Cell Reports. 11(1):70-87 (2018).

4. Wang H, Zhang K, Liu Y, Fu Y, Gao S, Gong P, Wang H, Zhou Z, Zeng M, Wu Z, Sun Y, Chen T, Li S, Liu L. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 15(1):114(2017).

5. Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, Wang H, Gong P, Deng W, Yin Y, Mao S, Wang L, Ding J, Li J, Keefe DL, Dawlaty MM, Wang J, Xu G, Liu L. Tet enzymes regulate telomere maintenance and chromosomal stability of mouse ESCs. Cell Reports 15:1809-1821 (2016).

6. Zhang H, Panula S, Petropoulos S, Edsgard D, Busayavalasa K, Liu L, Li X, Risal S, Shen Y, Shao J, Liu M, Li S, Zhang D, Zhang X, Gerner RR, Sheikhi M, Damdimopoulou P, Sandberg R, Douagi I, Gustafsson JA, Liu L, Lanner F, Hovatta O, Liu K. Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells. Nature Medicine 21:1116-1118 (2015).

7. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L, Chen L. Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci USA. 112: E5936–E5943 (2015).

8. Sung LY, Chang WF, Zhang Q, Liu CC, Liou JY, Chang CC, Ou-Yang H, Guo RP, Fu HF, TK Cheng, Ding ST, Chen CM, Okuka M, Keefe DL, Chen YE, Liu L, Xu J. Telomere elongation and naive pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer. Cell Reports 9:1603–1609 (2014).

9. Dan J, Y Liu, N Liu, M Chiourea, M Okuka, T Wu, X Ye,C Mou, LWang, LL Wang, Y Yin, J Yuan, B Zuo, F Wang, Z Li, XPan, ZYin, L Chen, DL Keefe,S Gagos, A Xiao, Liu L. Rif1 maintains telomere length homeostasis of ES cells by mediating heterochromatin silencing. Developmental Cell 29: 7–19 (2014).

10. Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells 31:2538-2550 (2013).

11. Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DM, Yin Y, Liu L, Keefe DL, Weissman SM. Robust measurement of telomere length in single cells. Proc Natl Acad Sci USA. 110:E1906-1912 (2013).

12. Jiang J, Lv W, Ye X, Wang L, Zhang M, Yang H, Okuka M, Zhou C, Zhang X, Liu L, Li J. Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Research 23:92-106 (2013).

13. Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L. Resveratrol protects against age-associated infertility in mice. Human Reproduction 28:707-717 (2013).

14. Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Research 22:757-768 (2012).

15. Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research 21:779-792 (2011).

16. Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 464:292-296 (2010).

17. Huang J, Okuka M, Wang F, Zuo B, Liang P, Kalmbach K, Liu L, Keefe DL. Generation of pluripotent stem cells from eggs of aging mice. Aging Cell 9:113-125  (2010).

18. Li C, Chen Z, Liu Z, Huang J, Zhang W, Zhou L, Keefe DL, Liu L. Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells. Human Molecular Genetics 18:2177-2187 (2009).

19. Chen Z, Liu Z, Huang J, Amano T, Li C, Cao S, Wu C, Liu B, Zhou L, Carter MG, Keefe DL, Yang X, Liu L. Birth of Parthenote mice directly from parthenogenetic embryonic stem cells. Stem Cells  27:2136-2145 (2009).

20. Huang J, Deng K, Wu H, Liu Z, Chen Z, Cao S, Zhou L, Ye X, Keefe DL, Liu L. Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation. Stem Cells  26:1883-1890 (2008)

21. Liu L, S. M. Bailey, M. Okuka, P. Mu?oz, C. Li, L. Zhou, C. Wu, E. Czerwiec, L. Sandler, A. Seyfang, M. A. Blasco and Keefe. D. L. Telomere lengthening early in development. Nature Cell Biology 9: 1436-1441 (2007)

22. Dai, Y., L. Wang, H. Wang, Y. Liu, Q. Lyu, N. Li, D.L. Keefe, D.F. Albertini and L. Liu. Abnormalities in centrosome remodeling following somatic cell nuclear transfer (SCNT) in bovine oocytes. Reproduction 131:1051-1061 (2006).

23. Liu, L., Franco, S., Spyropoulos, B., Moens, P.B., Blasco, M.A., and Keefe, D.L. Irregular telomeres impair meiotic synapsis and recombination in mice. Proc Natl Acad Sci U S A 101: 6496-6501 (2004)

24. Liu, L. and D.L. Keefe. Ageing-associated aberration in meiosis of oocytes from Senescence-Accelerated Mouse (SAM). Human Reproduction 17: 2678-2685 (2002)

25. Liu, L., M.A. Blasco and D.L. Keefe. Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles. EMBO Reports 3:230-234 (2002)

26. Liu, L., J.R. Trimarchi, P. Smith and D.L. Keefe. Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 1:40-46 (2002)

27. Dinnyés, A., Dai, Y., Barber, M., Liu, L., Xu, J., Zhou, P., and Yang, X. Development of cloned embryos from adult rabbit fibroblasts: effect of activation treatment and donor cell preparation. Biology of Reproduction 64: 257-263 (2001)

28. Liu, L. Cloning efficiency and differentiation. Nature Biotechnology 19:406 (2001)

29. Liu, L., Oldenbourg, R., Trimarchi, J.R., and Keefe, D.L. A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes. Nature Biotechnology 18: 223 – 225 (2000)






社会兼职

国际学术组织任职:


学术组织名称

职务

中国动物学会生殖生物学分会

常务理事

中国生物物理学会衰老生物学分会

理事

中国细胞生物学会衰老细胞生物学分会

副秘书长

中国细胞学会干细胞分会

理事

ISSCR

会员

Chinese Association of Science   & Technology in Connecticut

理事

H. Lee Moffitt Cancer Center   Tampa FL

会员

University of South Florida College   of Medicine

Adjunct Faculty

Marine Biological Laboratory

Adjunct Scientist



期刊任职:

学术期刊名称

职务

Journal of Assisted Reproduction and Genetics

编委

Frontiers in Oncology( Cancer Molecular Targets and   Therapeutics)

编委

Biology of Reproduction

前编委

Science China Life Sciences

前编委

Signal Transduction and Targeted Therapy

编委

Science Bulletin

编委


教学经历

1987.8-1990.9 江西农业大学动物科学与兽医系助教,教授本科生动物生化学及实验课程。

1993.7-1994.9 北京农业大学动物科学与技术学院讲师,教授本科生动物生殖学,指导研究生的生殖生理学实验。

2003.3-2008.3 中山大学生命科学学院长江学者特聘教授,教授研究生胚胎发育与干细胞生物学、小鼠胚胎操作实验指南课程,指导博士生10,硕士生8,博士后2人。

2007.5-至今南开大学特聘教授,教授本科生细胞生物学、生命科学前沿知识;研究生生物化学与分子生物学研究前沿专题讲座、分子细胞生物学、干细胞与发育生物学等课程,已指导毕业博士生11,硕士生9,出站博士后2人。


荣誉称号

2014年 第五届中国侨界(创新人才)贡献奖

2014年 国家百千万人才工程“有突出贡献中青年专家”

2012年 广东省科学技术二等奖

2011年 国家教育部高等学校科技进步二等奖

2004年 国家杰出青年基金获得者

2003年 长江学者特聘教授

2003年 美国生殖医学会辅助生殖技术一等奖

  


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