李明春

博士生导师，中共党员，九三学社社员。现任中国菌物学会理事，中国微生物学会教学工作部副主任委员，中国微生物学会真菌学专业委员会副主任委员，中国生物化学与分子生物学会基因专业委员会委员，天津市微生物学会理事。微生物学通报编委，中国真菌学杂志编委。 《微生物学》国家精品课和精品资源共享课负责人。获宝钢优秀教师奖，天津市教学名师，天津市师德先进个人，天津市优秀本科论文指导教师，获南开大学敬业奖教金一等奖、南开大学优秀教师二等奖及南开大学优秀博士学位和硕士学位论文指导教师称号。获天津市教学成果二等奖和南开大学教学成果一等奖多项。指导的研究生先后15人获国家奖学金，6名分获南开大学优秀博士和硕士学位论文，5名获南开大学优秀毕业生；指导的本科生2名获天津市优秀本科论文。 先后主持国家自然科学基金9项，教育部课题3项，“863”子课题1项，天津市支撑项目和重点基金8项，获天津市技术发明二等奖。研究方向是白念珠菌信号转导途径中重要因子的功能研究，特别是这些关键基因在白念珠菌的形态发育、致病性和耐药性中的作用及其分子机制。已在国内外期刊发表论文170余篇，其中SCI论文80余篇；出版论著11部，译著6部，已授权国家专利12项。

1986-1990，南开大学生物系微生物学专业，本科； 1994-2000，南开大学生命科学学院微生物学专业，博士。

1990-1994，天津中医药大学第一附属医院；1994-1999，南开大学生命科学学院，讲师；1999-2004，南开大学生命科学学院，副教授；2003-2004，美国明尼苏达大学，博士后； 2004-今，南开大学生命科学学院，教授。

1. 人类病原真菌致病的分子机制：白念珠菌信号转导途径中重要因子的功能研究，特别是毒力相关因子，研究这些关键基因在白念珠菌的形态发育、致病性和耐药性中的作用及其分子机制。

2.. 功能性纳米材料的构筑及其生物应用的研究。

 

做为项目负责人先后主持国家自然科学基金9项，教育部课题3项，“863”子课题1项，天津市支撑项目和重点基金8项，作为主要负责人参加多项国家级和省部级项目。获天津市技术发明二等奖。在国内外核心刊物发表论文170余篇，其中SCI论文80余篇；出版论著11部，译著6部，已授权国家专利12项。2006年获天津市技术发明二等奖。

1. Bing Zhang, Qilin Yu, Da Huo, Jianrong Li, Chao Liang, Hongyue Li, Xiao Yi, Chenpeng Xiao, Dan Zhang, Mingchun Li*. Arf1 regulates the ER-mitochondria encounter structure (ERMES) in a reactive oxygen species-dependent manner. The FEBS Journal, 285, 2004-2018, 2018

2. Chenpeng Xiao, Qilin Yu, Bing Zhang, Jianrong Li, Dan Zhang, Mingchun Li*. The mRNA export factor Sac3 maintains nuclear homeostasis and regulates cytoskeleton organization in Candida albicans. Future Microbiology, , 13(3): 283-296, 2018

3. Jianrong Li, Qilin Yu, Bing Zhang, Chenpeng Xiao, Tianyu Ma, Xiao Yi, Chao Liang, Mingchun Li*.Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulates unfolded protein response (UPR) that is independent on autophagy in Candida albicans. International Journal of Medical Microbiology, 308: 378-386, 2018

4. Chang Jia^#, Kai Zhang^#, Dan Zhang, Qilin Yu, Qiang Zhao, Chenpeng Xiao, Yijie Dong, Maoping Chu, Li Mingchun*. Roles of VPH2 and VMA6 in localization of V-ATPase subunits, cell wall functions and filamentous development in Candida albicans. Fungal Genetics and Biology, 114: 1-11, 2018

5. Meng Zhang, Qilin Yu, Chenpeng Xiao, Kai Zhang , Dan Zhang, Biao Zhang, Mingchun Li*. Disruption of SPT23 results in increased heat sensitivity due to plasma membrane damage in Pichia pastoris. FEMS Yeast Research, 18: 1-7, 2018

6. Chao Liang, Bing Zhang, Lifang Cui, Jianrong Li, Qilin Yu*, Mingchun Li*.Mgm1 is required for maintenance of mitochondrial function and virulence in Candida albicans. Fungal Genetics and Biology,120:42-52,2018

7. Qi Peng, Da Huo, Hongyue Li, Bing Zhang,Yang Li, Anping Liang, Hui Wang, Qilin Yu*, Mingchun Li*. ROS-independent toxicity of Fe₃O₄ nanoparticles to yeast cells: involvement of mitochondrial dysfunction. Chemico-Biological Interactions, 287:20-26, 2018

8. Chenpeng Xiao, Qilin Yu,Bing Zhang,Jianrong Li,Dan Zhang, Mingchun Li*. Role of the mRNA export factor Sus1 in oxidative stress tolerance in Candida albicans. Biochemical and Biophysical Research Communications. 496:253-259, 2018

9. Yijie Dong#, Dan Zhang#, Mingchun Li*. Loss of Ssq1 leads to mitochondrial dysfunction, activation of autophagy and cell cycle arrest due to iron overload triggered by mitochondrial ISC assembly defects in Candida albicans. The International Journal of Biochemistry & Cell Biology,85: 44-55, 2017

10. Qilin Yu; Honggang Wang; Mingchun Li*. Different toxicity of anatase and rutile TiO2 nanoparticles on macrophages: Involvement of ifference in affinity to proteins and phospholipids. Journal of Hazardous Materials, 335:125–134, 2017

11. Qilin Yu# *, Bing Zhang#, Mingchun Li*.Design of peptide-grafted graphene oxide targeting the actin cytoskeleton for efficient cancer therapy. ChemComm, 53, 11433-11436，2017

12. Kai Zhang, Chang Jia, Mingchun Li*. Contribution of VMA5 to vacuolar function, stress response, ion homeostasis and autophagy in Candida albicans. Future Microbiology, 12(13):1147–1166, 2017     

13. Meng Zhang, Qilin Yu, Mingchun Li*.UBX domain-containing proteins are involved in lipid homeostasis and stress responses in Pichia pastoris. The International Journal of Biochemistry & Cell Biology, 90:136-144, 2017

14. Xiao Yi, WeiliZhao, QilinYu*, Mingchun Li*. Mn3O4 nanoparticles cause endoplasmic reticulum stress-dependent toxicity to Saccharomyces cerevisiae. RSC Advances, 7(73)：46028-46035, 2017

15. Jianrong Li; Bing Zhang;Qilin Yu*;Mingchun Li*.Role of the inositol polyphosphate multikinase Ipk2 in regulation of hphal development, calcium signaling and secretion in Candida albicans. Mycopathologia, 182:609-623, 2017

16. Yu Qilin; Zhang Bing; Li Jianrong; Du Tingting; Yi Xiao; Li Mingchun*; Chen Wei*; Alvarez, Pedro. Graphene oxide significantly inhibits cell growth at sublethal concentrations by causing extracellular iron deficiency. Nanotoxicology, 11:(9-11),1102-1114, 2017

17. Dan Zhang, Yijie Dong, MingchunLi*. Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans. Future Microbiology, 12(15):1397–1412, 2017

18. Bing Zhang; Qilin Yu;Mingchun Li*. The Candida albicans fimbrin Sac6 regulates oxidative stress response (OSR) and morphogenesis at the transcriptional level. Biochimica et Biophysica Acta- Molecular Cell Research, 1863, 2255–2266, 2016

19. Qilin Yu; Bing Zhang; Mingchun Li*. Endoplasmic reticulum-derived reactive oxygen species (ROS) is involved in toxicity of cell wall stress to Candida albicans. Free Radical Biology & Medicine, 99: 572–583, 2016

20. Qilin Yu,Jianrong Li, Mingchun Li*. Inhibition of gold nanoparticles (AuNPs) on pathogenic biofilm formation and invasion to host cells. Scientific reports, | 6:26667 | DOI: 10.1038/srep26667,2016

21.Zhe Liu; Meng Zhang;Mingchun Li*. TiO2 nanoparticles cause cell damage independent of apoptosis and autophagy by impairing the ROS-scavenging system in Pichia pastoris. Chemico-Biological Interactions, 252:9-18, 2016     

22.Feiyang Ma, Yueqi Zhang, Mingchun Li*. Role of Aif1 in regulation of cell death under environmental stress in Candida albicans. Yeast, 33: 493-506, 2016

23.Meng Zhang,Qilin Yu, Mingchun Li*.Graphene oxide induces plasma membrane damage, reactive oxygen species accumulation and fatty acid profiles change in Pichia pastoris. Ecotoxicology and Environmental Safety, 132:372–378, 2016

24.Yulu Chen, Qilin Yu, Mingchun Li*. The malfunction of peroxisome has an impact on the oxidative stress sensitivity in Candida albicans. Fungal Genetics and Biology, 95:1-12, 2016

25.Meng Zhang, Qilin Yu, Mingchun Li* Lipid homeostasis is involved in plasma membrane and endoplasmic reticulum stress in Pichia pastoris. Biochemical and Biophysical Research Communications. 478: 777-783, 2016

26. Chang Jia, Mingchun Li*. Tfp1 is required for ion homeostasis, fluconazole resistance and N-Acetylglucosamine utilization in Candida albicans. Biochimica et Biophysica Acta- Molecular Cell Research, 1853: 2731–2744, 2015

27. Yijie Dong, Mingchun Li*. The Ccz1 mediates the autophagic clearance of damaged mitochondria in response to oxidative stress in Candida albicans. The International Journal of Biochemistry & Cell Biology, 69:41–51, 2015

28.Qilin Yu, Mingchun Li*. Novel mechanisms of surfactants against Candida albicans growth and morphogenesis. Chemico-Biological Interactions, 227:1-6, 2015

29.Qilin Yu, Mingchun Li*. Candida albicans autophagy, no longer a bystander: its role in tolerance to ER stress-related antifungal drugs.Fungal Genetics and Biology,81:238-249, 2015

30. Ning Xu, Mingchun Li*. Convergent regulation of Candida albicans Aft2 and Czf1 in invasive and opaque filamentation. Journal of Cellular Biochemistry, 116:1908–1918, 2015

31.Qilin Yu, Mingchun Li*. TiO2 nanoparticles promotes production of unsaturated fatty acids (UFAs) fighting against oxidative stress in Pichia pastoris. RSC Advances, 5,41033 – 41040, ,2015

32.Bing Zhang, Mingchun Li*. The actin-related protein Sac1 is required for morphogenesis and cell wall integrity in Candida albicans. Fungal Genetics and Biology, 81:261-270, 2015

33. Chengdong Zhang*, Mingchun Li*. Edible fungus degrade bisphenol A with no hurmful effect on its fatty acids composition. Ecotoxicology and Environmental Safety, 118:126–132, 2015

34. Meng Zhang,Mingchun Li*.Deletion of genes encoding fatty acid desaturases leads to alterations in stress sensitivity in Pichia pastoris. FEMS Yeast Research, 10.1093/femsyr/fov020,4-28,2015

35. Qilin Yu, Mingchun Li*. Interaction between the Vacuole, the Mitochondria and Oxidative Stress Response Is Governed by the Transient Receptor Potential Channel in Candida albicans. Free Radical Biology & Medicine, 77:152-167, 2014

36.Ning Xu, Mingchun Li*. Cellular iron homeostasis mediated by the Mrs4-Ccc1-Smf3 pathway is essential for mitochondrial function, morphogenesis and virulence in Candida albicans. Biochim et Biophys Acta-Molecular Cell Research, 1843（3）:629-639, 2014   

37.Qilin  Yu, Mingchun  Li*. A Novel Role of the vacuolar calcium channel Yvc1 in stress response, morphogenesis and pathogenicity of Candida albicans.  International Journal of Medical Microbiology, 304(3):339-350 , 2014  

38.Meiqing Sun, Mingchun Li*. Lead sulfide nanoparticles increase cell wall chitin content and induce apoptosis in Saccharomyces cerevisiae. Journal of hazardous materials, 273(30): 7–16, 2014

39.Chang Jia, Mingchun Li*. Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans. Fungal Genetics and Biology,71: 58–67, 2014

40.Qilin Yu, Mingchun Li*. The calcium channel blocker verapamil inhibits oxidative stress response in Candida albicans. Mycopathologia, 177( 3): 167-177, 2014  

41.Ning Xu, Mingchun Li*. Novel role of Candida albicans ferric reductase gene CFL1 in iron acquisition, oxidative stress tolerance, morphogenesis and virulence. Research in Microbiology, 165:252-261, 2014

42.Qilin Yu, Mingchun Li*. Inhibitory effect of verapamil on Candida albicans hyphal development, adhesion and gastrointestinal colonization. FEMS Yeast Research,14(4) : 633–641, 2014

43.Xiao h Ding, Ming C Li*. The type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans. Biochemical and Biophysical Research Communications, 46:1073-1078, 2014

44. Qilin Yu, Mingchun Li*.A novel role of the ferric reductase Cfl1 in cell wall integrity, adhesion and invasion to host cells in Canida albicans. FEMS Yeast Research, 14(7): 1037-1047, 2014

45.Qilin Yu, Mingchun Li*. Interaction between lead sulfide nano-dendrites and Saccharomyce cerevisiae is involved in nanotoxicity. RSC Advances, 4 (39): 20371-20378, 2014

46.Meiqing Sun, Mingchun Li*. A novel toxicity mechanism of CdSe nanoparticles to Saccharomyces cerevisiae: Enhancement of vacuolar membrane permeabilization (VMP). Chemico-Biological Interactions, 220:208-213, 2014  

47.Qilin Yu, Mingchun Li*. The P-type ATPase Spf1 is required for endoplasmic reticulum functions and cell wall integrity in Candida albicans. Int J Med Microbiol, 303:257-266, 2013

48.Qilin Yu, Mingchun Li*. In vitro activity of verapamil alone and in combination with fluconazole or tunicamycin against Candida albicans biofilms. Int J Antimicrob Agents, 41 (2):179-182, 2013

49.Ning Xu, Mingchun Li*. Aft2, a novel transcription regulator, is required for iron metabolism, surface adhesion and hyphal development in Candida albicans. PLoS ONE , 8(4): e62367, 2013

50.Xiaohui Ding, Mingchun Li*. Ecm7, a regulator of HACS, functions in calcium homeostasis maintenance, oxidative stress response and hyphal development in Candida albicans. Fungal Genet Biol, 57:23-32, 2013

51.Xinxin Cheng, Mingchun Li*. Novel insight into the expression and function of the multicopper oxidases in Candida albicans. Microbiology-SGM, 159(6), 1044-1055 , 2013

52. 主编《微生物学原理与应用》，科学出版社，2018.5

53. 主编《真菌生物学实验》，普通高等教育“十二五”国家级规划教材，微生物学实验教程系列，科学出版社，2014.7

54. 主编《真菌细胞生物学》，科学出版社，2013.6

55. 主编《微生物学》，普通高等教育“十一五”国家级规划教材，高等教育出版社,2010.11

56. 主编《普通真菌学》（第二版），普通高等教育“十一五”国家级规划教材，高等教育出版社,2010.6

57. 主译精要速览系列《微生物学》（第三版），中译版，科学出版社,2010.6

58. 主译《BROCK微生物生物学》(11版），科学出版社,2009.1

中国菌物学会理事

中国微生物学会教学工作部副主任委员

中国微生物学会真菌学专业委员会副主任委员

中国生物化学与分子生物学会基因专业委员会委员

天津市微生物学会理事

微生物学通报编委

中国真菌学杂志编委

本科生： 负责并主讲《微生物学》国家精品课，国家级精品资源共享课

负责并主讲《生物技术综合实验》

负责并主讲《微生物学基础研讨》

硕士生：主讲《分子真菌学与技术》

负责并主讲《分子微生物学技术》

博士生： 《分子微生物学进展》

指导本科生《开放实验专题》、指导伯苓班《科研训练》、指导本科生创新科研项目及本科生毕业论文等。

还曾主讲过真菌学、现代真菌学、微生物细胞结构与功能、分子微生物学大实验、综合微生物学实验、真菌学实验等课程。

主持各类教改项目10余项；主编了多部“九五”、“十一五”、“十二五”国家级规划教材；2013年主持的“微生物学系列化教材的建设”获天津市级教学成果二等奖；2013年、2009年两次获南开大学教学成果一等奖。

教育部宝钢优秀教师奖；

天津市教学名师；

天津市师德先进个人；

天津市优秀本科论文指导教师称号；

《微生物学通报》编辑委员会优秀编委；

《中国真菌学杂志》编辑委员会优秀编委；

南开大学优秀博士学位论文指导教师称号；

南开大学优秀硕士学位论文指导教师称号；

南开大学现代远程教育学院优秀教师。