Liminggang

Dr. Li Minggang has been studied in HOKKAIDO and TOKYO University of Japan for five years and got a PhD degree in 1997. He is working in Department of Genetics and Cell Biology, College of Life Sciences, Nankai University as professor since 2000. He has been served on the dean of Genetics and Cell Biology department (2006-2009), vice director of institute for molecular biology (2001-2005)，president of Tianjin Genetics Academy (2006-2015)，director of the laboratory of biotech and New medication. There are three major research directions，Mechanism of diabetes and its new bio-medication, transgenic plant for dietary therapy of diabetes, Environment-friendly bio-energy sources，in his laboratory. He has the advisory title of graduate students for doctor’s degree and master’s degree in the college. He has published more than 100 scientific papers and three authoring books.

1981 Yanbian University, China Bachelor 1984 Northeast Agriculture University, China Master 1997 HOKKAIDO University, Japan Doctor

Professor of Guizhou University, Yantai University and Tianjin nornal University at one time. Professor of Nankai University from years 2000.

• Mechanism of diabetes and its new bio-medication

• Transgenic plant for dietary therapy of diabetes

• Environment-friendly bio-energy sources

Selected Publications:

[1] Li Minggang et al. Parkin regulates Eg5 expression by Hsp70 ubiquitination- dependent inactivation of c-Jun NH₂-terminal kinase. Journal of Biological Chemistry, 2008, 283(51):35783–35788

[2] Li Minggang et al. Generation of transgenic cucumbers with expression of a ten-tandem repeat long-acting GLP-1 analogue and their biological function on diabetic rats. Chinese Science Bulletin, 2009, 54(24), 4658-4663

[3] Li Minggang et al. Functional analysis of an Aspergillus ficuum phytase gene in Saccharomyces cerevisiae and its root-specific secretory expression in transgenic soybean plants. Biotechnol Lett. 2009,31(8)，1297-1303

[4] Li Minggang et al. The complete mitochondrial genome of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae). Int. J. Biol. Sci. 2010, 6, 172-186

[5] Li Minggang et al. Cloning of the gene encoding cucumber lumazine synthase and an analysis of its promoter activity in cucumber. Canadian Journal of Plant Science. (Can. J. Plant Sci.)2010, 90: 809-818

[6] Li Minggang et al.Construction of a Functional-Complementary Dual Insulinotropic Peptide rolGG and Its Therapeutic Effect on Type 2 Diabetes. Int J Pept Res Ther，2012, 18：327-333

[7] Li Minggang et al. Expression of rolGLP-HV in E. coli and its dual-function for the treatment of Diabetes and thrombosis. Int J Pept Res Ther.，2013，19，257-263

[8] Li Minggang et al. Expression and Purification of Optimized rolGLP-1, A Novel GLP-1 Ana-log, in Escherichia Coli BL21(DE3) and its Good Glucoregulatory Effect on Type 2 Diabetic Mice. Current Pharmaceutical Biotechnology, 2013, 14, 985-994

[9] Li Minggang et al. Pharmacokinetics, Pharmacodynamics, and cytotoxicity of Recombinant Orally-administrated long-lasting GLP-1 and its Therapeutic Effect on db/db Mice. Exp Clin Endocrinol Diabetes 2013, 121: 1–8

[10] Li Minggang et al. Liver histone H3 methylation and acetylation may associate

with type 2 diabetes development. J Physiol Biochem, 2015, 71:89–98

[11]Li Minggang et al.Codon optimization and expression of irisin in Pichia pastoris GS115, International Journal of Biological Macromolecules 2015, 21-26

[12] Li Minggang et al.Expression of CTB-10×rolGLP-1 in E.coli and Its Therapeutic Effect on Type 2 Diabetes，Current Pharmaceutical Biotechnology, 2015, 16, 564-572

[13] Li Minggang et al. Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice, International Journal of Biological Macromolecules 2016,84, 457–463

[14] Li Minggang et al.Construction of a difunctional peptide 5rolGLP-HV and its therapeutic effect on type 2 Diabetes and Thrombosis in mice, Appl Biochem Biotechnol, 2016, 179, 59–74

[15] Li Minggang et al.Toxicology Assessment of a Dual-Function Peptide in Mice, Appl Biochem Biotechnol, 2016, 180(7), 1276-1285

[16] Li Minggang et al.Pharmacological Effects and Pharmacokinetic Properties of a Dual-Function Peptide 5rolGLP-HV, Appl Biochem Biotechnol, 2016, 181，2，483-494

[17] Li Minggang et al.Effect of Vanadyl Rosiglitazone, a New Insulin-Mimetic Vanadium Complexes, on Glucose Homeostasis of Diabetic Mice, Appl Biochem Biotechnol, 2016, 180(5), 841-851

[18] Li Minggang et al.Acute Toxicity, Twenty-eight Days Repeated Dose Toxicity and Genotoxicity of Vanadyl Trehalose in Kunming Mice, Regulatory Toxicology and Pharmacology 85 (2017) 86-97

[19] Li Minggang et al.Therapeutic Effect of Vanadyl Rosiglitazone on Diabetic mice.Acta Scientiarum Naturalium Universitatis Nankaiensis2017，50（6）：37-42

[20] Li Minggang et al.Primary study on the toxic mechanism of vanadyl trehalose in Kunming mice, Regulatory Toxicology and Pharmacology 94, 94:1-7, 2018 April, 1-7

Honorary President of TianjinGenetics Academy

Profess 《Advanced molecular Genetics》 for graduate students and 《Genetics》undergraduate students