刘祥

以病原微生物主要研究对象的结构生物学研究以及结构辅助药物设计研究

关注脂类分子的代谢与合成研究，以及相关pks/nrps研究内容

主持国家自然基金面上项目一项，正在进行中

主持省部级项目子课题一项，正在进行中

主持国家自然科学基金青年科学基金项目一项，已经结项；

主持天津自然科学基金青年项目一项，已经结项；

主持天津市科技计划项目，已经结项；

正在参与国家重点研发计划子项目，骨干人员

近五年发表文章

1.    Tang, Y.; Liu, Y.; Zhang, M.; Lan, W.; Ma, M.; Chen, C.; Wu, S.; Chen, R.; Yan, Y.; Feng, L.; Li, Y.; Guddat, L. W.; Gao, Y.; Liu, X.; Rao, Z., The structural and functional analysis of mycobacteria cysteine desulfurase-loaded encapsulin. Commun Biol 2024,7 (1), 1656.

2.    Huang, Z.; Zhang, K.; Jiang, Y.; Wang, M.; Li, M.; Guo, Y.; Gao, R.; Li, N.; Wang, C.; Chen, J.; Wang, J.; Liu, N.; Liu, X.; Liu, S.; Wei, M.; Yang, C.; Yang, G., Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH. Acta Pharm Sin B 2024,14 (9), 4001-4013.

3.    Yan, M.; Cao, L.; Zhao, L.; Zhou, W.; Liu, X.; Zhang, W.; Rao, Z., The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms. Front Microbiol 2023,14, 1090534.

4.    Lin, M.; Zeng, X.; Duan, Y.; Yang, Z.; Ma, Y.; Yang, H.; Yang, X.; Liu, X., Molecular mechanism of ensitrelvir inhibiting SARS-CoV-2 main protease and its variants. Commun Biol 2023,6 (1), 694.

5.    Duan, Y.; Zhou, H.; Liu, X.; Iketani, S.; Lin, M.; Zhang, X.; Bian, Q.; Wang, H.; Sun, H.; Hong, S. J.; Culbertson, B.; Mohri, H.; Luck, M. I.; Zhu, Y.; Liu, X.; Lu, Y.; Yang, X.; Yang, K.; Sabo, Y.; Chavez, A.; Goff, S. P.; Rao, Z.; Ho, D. D.; Yang, H., Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature 2023,622 (7982), 376-382.

6.    Zhao, Y.; Zhu, Y.; Liu, X.; Jin, Z.; Duan, Y.; Zhang, Q.; Wu, C.; Feng, L.; Du, X.; Zhao, J.; Shao, M.; Zhang, B.; Yang, X.; Wu, L.; Ji, X.; Guddat, L. W.; Yang, K.; Rao, Z.; Yang, H., Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proc Natl Acad Sci U S A 2022,119 (16), e2117142119.

7.    Chen, R.; Yuan, J.; Shi, X.; Tang, W.; Liu, X., Crystal structures of FadD32 and pks13-ACP domain from Corynebacterium diphtheriae. Biochem Biophys Res Commun 2022,590, 152-157.

8.    Zhang, Q.; Liu, X.; Liu, H.; Zhang, B.; Yang, H.; Mi, K.; Guddat, L. W.; Rao, Z., Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding. Front Microbiol 2021,12, 780954.

9.    Wei, M.; Zhou, Y.; Li, C.; Yang, Y.; Liu, T.; Liu, Y.; Wei, Y.; Liu, N.; Liu, S.; Wang, Q.; Cao, S.; Sun, Y.; Sheng, P.; Lu, C.; Yang, C.; Liu, X.; Yang, G., 5alpha-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. J Med Chem 2021.

10.   Li, X.; Xie, M.; Lu, C.; Mao, J.; Cao, Y.; Yang, Y.; Wei, Y.; Liu, X.; Cao, S.; Song, Y.; Peng, J.; Zhou, Y.; Jiang, Q.; Lin, G.; Qin, S.; Qi, M.; Hou, M.; Liu, X.; Zhou, H.; Yang, G.; Yang, C., Design and synthesis of Leukotriene A4 hydrolase inhibitors to alleviate idiopathic pulmonary fibrosis and acute lung injury. Eur J Med Chem 2020,203, 112614.

11.   Jin, Z.; Zhao, Y.; Sun, Y.; Zhang, B.; Wang, H.; Wu, Y.; Zhu, Y.; Zhu, C.; Hu, T.; Du, X.; Duan, Y.; Yu, J.; Yang, X.; Yang, X.; Yang, K.; Liu, X.; Guddat, L. W.; Xiao, G.; Zhang, L.; Yang, H.; Rao, Z., Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol 2020,27 (6), 529-532.

12.   Jin, Z.; Du, X.; Xu, Y.; Deng, Y.; Liu, M.; Zhao, Y.; Zhang, B.; Li, X.; Zhang, L.; Peng, C.; Duan, Y.; Yu, J.; Wang, L.; Yang, K.; Liu, F.; Jiang, R.; Yang, X.; You, T.; Liu, X.; Yang, X.; Bai, F.; Liu, H.; Liu, X.; Guddat, L. W.; Xu, W.; Xiao, G.; Qin, C.; Shi, Z.; Jiang, H.; Rao, Z.; Yang, H., Structure of M(pro) from COVID-19 virus and discovery of its inhibitors. Nature 2020.

13.   Dai, W.; Zhang, B.; Su, H.; Li, J.; Zhao, Y.; Xie, X.; Jin, Z.; Liu, F.; Li, C.; Li, Y.; Bai, F.; Wang, H.; Cheng, X.; Cen, X.; Hu, S.; Yang, X.; Wang, J.; Liu, X.; Xiao, G.; Jiang, H.; Rao, Z.; Zhang, L. K.; Xu, Y.; Yang, H.; Liu, H., Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science 2020.

14.   Chen, X.; Chen, J.; Yan, B.; Zhang, W.; Guddat, L. W.; Liu, X.; Rao, Z., Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proc Natl Acad Sci U S A 2020,117 (28), 16324-16332

主讲生科院本科课程《生物统计学》、《生物统计学基础》

以往经历

主讲药学院本科课程《生物统计学基础》

主讲药学院研究生课程《结构辅助药物设计导论》

天津市“131”第二层次人才；

天津市第五批创新人才团队计划负责人；