Yong Liu

http://www.liu-lab-biomat.com/

2013.06– 2016.06 Ph.D., Polymer Chemistry and Physics, Supervised by Prof. Linqi Shi, Institute of Polymer Chemistry, Department of Chemistry Nankai University (NKU), Tianjin, China 2010.06– 2013.06 M.S., Organic Chemistry, Supervised by Prof. Zhongwen Wang, Department of Chemistry,NKU, Tianjin, China 2006.06– 2010.06 B. S., Chemistry, Supervised by Prof. Yu-Zhong Wang, Department of Chemistry, Sichuan University, Sichuan, China

2024/01–Present Professor, Nankai University 2021/05–Present Professor, Wenzhou Insititue, University of Chinese Academy of Sciences 2019/07–2021/05 Research Associate Professor, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, China 2016/06–2019/06 Postdoctoral researcher, Department of Biomedical Engineering, University of Groningen, University Medical Center Groningen, The Netherlands

1. Designing, synthesizing, and characterizing high molecular polymers with intelligent responses; preparing, separating, and multifunctionalizing nano-assemblies.

2. Developing intelligent polymer-based nanosystems to overcome drug resistance in bacteria and cancer.

3. Exploring the applications of natural biological materials in bacterial infections and cancer immunotherapy.

Papers（# co-first authorship，* co-corresponding authorship）

1. Xinghong Zhao#,*, Xinyi Zhong#, Shinong Yang#, Jiarong Deng, Kai Deng, Zhengqun Huang, Yuanfeng Li, Zhongqiong Yin, Yong Liu*, Jakob H. Vield, Hongping Wan*. Guiding antibiotics towards their target using bacteriophage proteins. Nature Communications, 2024, 15, 5287. 

2. Yuanfeng Li#, Lei Hua#, Wei He#, Lei Chen, Yin-Zi Piao, Mengna Peng, Dongdong Li*, Linqi Shi, Yong Liu*. Microenvironment-Adaptive Metallo-Polymeric Nanodecoys via Subcomponent Coordination for Bacterial Biofilm Eradication and Immunomodulation. Adv. Funct. Mater., 2024, 2405487.

3. Lei Chen#, Mengna Peng#, Huaping Li#, Jianan Zhou, Wei He, Rongdang Hu,* Fangfu Ye,* Yuanfeng Li,* Linqi Shi, and Yong Liu*. Metal-Phenolic Network with Pd Nanoparticle Nodes Synergizes Oxidase-Like and Photothermal Properties to Eradicate Oral Polymicrobial Biofilm-Associated Infections. Adv. Mater. 2024, 36, 2306376.

4. Xiaowen Hu#, Dongdong Li#, Huaping Li#, Yinzi Piao*, Hongping Wan, Tieli Zhou, Mahdi Karimi, Xinghong Zhao,* Yuanfeng Li,* Linqi Shi, Yong Liu*. Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance, Adv. Mater., 2024, 2406156. 

5. Yaran Wang, Fan Wu, Yuanfeng Li*, Siran Wang, Yijin Ren, Linqi Shi,* Henny C. van der Mei*, Yong Liu*. Ellagic Acid-Modified Gold Nanoparticles to Combat Multi-Drug Resistant Bacterial Infections In Vitro and In Vivo. Materials Horizons, 2024, https://doi.org/10.1039/D4MH00642A

6. Lei Chen#, Mengna Peng#, Wei He#, Yuanfeng Li*, Xiaoli Hu*, Jian Xiao*, Linqi Shi, Yong Liu*. Microenvironment-Adaptive Nanodecoy Synergizes Bacterial Eradication, Inflammation Alleviation, and Immunomodulation in Promoting Biofilm-Associated Diabetic Chronic Wound Healing Cascade. Aggregate, 2024, e640.

7. Yin-Zi Piao#, Linzhu Su#, Xiaoli Hu#, Wei He, Xiaowen Hu, Calvin Andeve Omolo, Thirumala Govender,*, Huaping Li,*, Haodan Xue, Yicen Ge, Yong Liu* , Linqi Shi, Yuanfeng Li*. One-component lipidic bicontinuous nanospheres as a smart drug loading platform to eradicate candida biofilms in oral and vaginal infection. Nano Today, 2024, 102123.

8. Yumeng Wang#, Xinghong Zhao#, Xingjian Zhou#, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao*, Keqing Shi*, Yong Liu*, Yuanfeng Li*, Linqi Shi. A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing. Journal of Controlled Release, 2024, 368, 740-755. 

9. Xiaowen Hu#, Yuanfeng Li#, Yinzi Piao#, Mahdi Karimi, Yang Wang*, Feng Wen, Huaqiong Li, Linqi Shi*, and Yong Liu*. Two-Tailed Dynamic Covalent Amphiphile Combats Bacterial Biofilms. Adv. Mater. 2023,  35, 2301623.

10. Lei Chen,# Mengna Peng,# Jianan Zhou, Xiaowen Hu, Yinzi Piao, Huaping Li,* Rongdang Hu,* Yuanfeng Li,* Linqi Shi, and Yong Liu*. Supramolecular Photothermal Cascade Nano-Reactor Enables Photothermal Effect, Cascade Reaction, and In Situ Hydrogelation for Biofilm-Associated Tooth-Extraction Wound Healing. Adv. Mater. 2023,  35, 2301664.

11. Yuxun Ding#, Xiaowen Hu#, Yinzi Piao, Rong Huang, Xiaojian Yan*, Hui Sun, Yuanfeng Li*, Linqi Shi, Yong Liu*. Lipid Prodrug Nano-Assemblies via Dynamic Covalent Boronates. ACS Nano, 2023, 17, 6601–6614.

12. Yizhou Zhan#, Xiaowen Hu#, Yuanfeng Li*, Yaran Wang, Hua Chen, Calvin Omolo, Thirumala Govender, Huaping Li*, Fan Huang*, Linqi Shi, Xiaoli Hu*, Yong Liu*. Antimicrobial Hybrid Amphiphile via Dynamic Covalent Bonds Enables Bacterial Biofilm Dispersal and Bacteria Eradication. Adv. Funct. Mater., 2023, 33, 2214299.

13. Fan Wu#, Jinghang Ma#, Yang Wang,* Lingping Xie, Xiaojian Yan, Linqi Shi, Yuanfeng Li*, Yong Liu*. Single copper atom photocatalyst powers an integrated catalytic cascade for drug-resistant bacteria elimination. ACS Nano, 2023, 17, 2980-2991.

14. Yuanfeng Li#, Yin-Zi Piao#, Hua Chen#, Keqing Shi, Juqin Dai, Siran Wang, Tieli Zhou*, Anh-Tuan Le, Yaran Wang, Fan Wu, Rujiang Ma*, Linqi Shi, Yong Liu*. Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation. Bioact. Mater., 2023, 27, 288-302. 

15. Yuanfeng Li , Junjie Chi, Pingwei Xu, Xing Dong, Anh-Tuan Le, Keqing Shi*, Yong Liu*, Jian Xiao*. Supramolecular G-quadruplex Hydrogels: Bridging Fabrication to Biomedical Application. J. Mater. Sci. Tech., 2023, 155, 238-252.

16. Yaran Wang#, Jianan Zhou#, Lu Yuan#, Fan Wu, Lingping Xie, Xiaojian Yan, Huaping Li*, Yuanfeng Li*, Linqi Shi, Rongdang Hu*, Yong Liu*. Neighboring Carboxylic Acid Boosts Peroxidase-Like Property of Metal-Phenolic Nano-Networks in Eradicating Streptococcus mutans Biofilms. Small, 2023, 19, 2206657. 

17. Yin-Zi Piao#,Yu Qi#, Xiao-Wen Hu, Yaran Wang, Yuanfeng Li,* Tieli Zhou, Linqi Shi,* Yong Liu,* and Chaoyang Zhou*. GOx-encapsulated iron-phenolic networks power catalytic cascade to eradicate bacterial biofilms. J. Control.Release, 2022, 352, 1-14.  

18. Fan Huang#, Xiaoyao Cai#, Xiaoxue Hou, Yumin Zhang, Jinjian Liu, Lijun Yang*, Yong Liu* and Jianfeng Liu* . A Dynamic Covalent Polymeric Antimicrobial for Conquering Drug-Resistant Bacterial Infection. Exploration, 2022, 2, 20210145.

19. Yuanfeng Li, Linzhu Su, Yongxin Zhang, Yong Liu*, Fan Huang*, Yijin Ren, Yingli An, Linqi Shi*, Henny C. van der Mei*, Henk J. Busscher. A G-quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment–a Study in Diabetic Mice, Adv. Sci. 2022, 2103485. 

20.Yong Liu, Lichen Yin* α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery. Adv. Drug Deliv. Rev., 2021, 171, 139-163.   

21. Jian Shu#, Xudong Li#, Juanjuan Dang, Yong Liu*, Shanzhou Duan, Rongying Zhu, Lichen Yin*, Yongbing Chen* Drug resistance reversal by interventing cancer bioenergetics with spherical helical polypeptide-potented gene silencing. Chem. Eng. J., 2021, 414, 128545.  

22. Yuxun Ding, Yingjin Xu, Wenzeng Yang, Pei Niu, Xue Li, Yidan Chen, Zhanyong Li, Yang Liu, Yingli An, Yong Liu*, Wenzeng Shen*, Linqi Shi*. Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy. Nano Today, 2020, 35, 100970. 

23. Yuanfeng Li#, Yong Liu#, Yijin Ren, Linzhu Su, Ang Li, Yingli An, Vincent Rotello, Zhanzhan Zhang, Yin Wang, Yang Liu, Sidi Liu, Jian Liu, Jon D Laman, Linqi Shi*, Henny C van der Mei*, Henk J Busscher. Coating of a novel antimicrobial nanoparticle with a macrophage membrane for the selective entry into infected macrophages and killing of intracellular staphylococci. Adv. Funct. Mater., 2020, 30, 2004942.                            

24. Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou*, Mengying Hou, Xudong Li, Yong Liu*, Lichen Yin*. Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters. Biomaterials 2020, 255, 120166.              

25. Linzhu Su, Yuanfeng Li, Yong Liu*, Rujiang Ma, Yang Liu, Fan Huang*, Yingli An, Yijin Ren, Henny C van der Mei, Henk J Busscher*, Linqi Shi*. Antifungal‐inbuilt metal–organic‐frameworks eradicate Candida albicans biofilms. Adv. Funct. Mater., 2020, 30, 2000537.

26. Yong Liu, Linqi Shi*, Linzhu Su, Henny C van der Mei, Paul C Jutte, Yijin Ren, Henk J Busscher*. Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control. Chem. Soc. Rev., 2019, 48(2), 428-446. 

27. Yong Liu, Henny C van der Mei*, Bingran Zhao, Yan Zhai, Tangjian Cheng, Yuanfeng Li, Zhenkun Zhang, Henk J Busscher, Yijin Ren, Linqi Shi*. Eradication of multidrug‐resistant staphylococcal infections by light‐activatable micellar nanocarriers in a murine model. Adv. Funct. Mater., 2017, 27(44), 1701974. 

28. Yong Liu, Henk J Busscher, Bingran Zhao, Yuanfeng Li, Zhenkun Zhang, Henny C van der Mei*, Yijin Ren, Linqi Shi*. Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms. ACS Nano, 2016, 10(4), 4779-4789. 

29. Yong Liu#, Yuanfeng Li#, Linqi Shi*. Controlled drug delivery systems in eradicating bacterial biofilm-associated infections, J. Control.Release, 2021, 329, 1102-1116

30. Jing Yan, Rongying Zhu, Fan Wu, Ziyin Zhao, Huan Ye, Mengying Hou, Yong Liu*, Lichen Yin*. iRGD-reinforced, photo-transformable nanoclusters toward cooperative enhancement of intratumoral penetration and antitumor efficacy. Nano Research 2020, 13, 2706–2715. 

31. Yong Liu, Yuanfeng Li, Damla Keskin, Linqi Shi*. Poly (β‐amino esters): synthesis, formulations, and their biomedical applications. Adv. Healthc. Mater., 2019, 8(2), 1801359.                    

32. Yongjuan Li, Jian Hu, Xun Liu, Yong Liu*, Shixian Lv, Juanjuan Dang, Yong Ji*, Jinlin He, Lichen Yin*. Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment. Nano Research, 2019, 12(5), 999–1008.                           

33. Yong Liu, Yijin Ren, Yuanfeng Li, Linzhu Su, Yumin Zhang, Fan Huang, Jinjian Liu, Jianfeng Liu, Theo G van Kooten, Yingli An, Linqi Shi*, Henny C van der Mei*, Henk J Busscher. Nanocarriers with conjugated antimicrobials to eradicate pathogenic biofilms evaluated in murine in vivo and human ex vivo infection models. Acta Biomater., 2018, 79, 331-343. 

34. Yuanfeng Li#, Yong Liu#, Rujiang Ma, Yanling Xu, Yunliang Zhang, Baoxin Li, Yingli An, Linqi Shi. A G-quadruplex hydrogel via multicomponent self-assembly: formation and zero-order controlled release. ACS Appl. Mater. Interf., 2017, 9(15), 13056-13067. 

35. Chenglong Ge, Huan Ye, Fan Wu, Junliang Zhu, Ziyuan Song, Yong Liu*, Lichen Yin*. Biological applications of water-soluble polypeptides with ordered secondary structures. Journal of Materials Chemistry B, 2020, 8, 6530-6547. 

36. Yuchen Wu, Shixian Lv, Yongjuan Li, Hua He, Yong Ji, Mingfeng Zheng*, Yong Liu*, Lichen Yin*. Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy. Biomaterials Science, 2020, 8, 949-959. 

37. Rongying Zhu, Hua He, Yong Liu*, Desheng Cao, Jin Yan, Shanzhou Duan, Yongbing Chen*, Lichen Yin*. Cancer-selective bioreductive chemotherapy mediated by dual hypoxia-responsive nanomedicine upon photodynamic therapy-induced hypoxia aggravation. Biomacromolecules, 2019, 20, 2649-2656. 

38. Huan Ye, Yang Zhou, Xun Liu, Yongbing Chen*, Shanzhou Duan, Rongying Zhu, Yong Liu*, Lichen Yin*. Recent advances on reactive oxygen species (ROS)-responsive delivery and diagnosis system. Biomacromolecules 2019, 20(7) 2441-2463.                                                   

39. Qiujun Liang, Fangfang Li, Yongjuan Li, Yong Liu*, Min Lan, Songhua Wu, Xuejie Wu, Yong Ji*, Rujing Zhang, Lichen Yin*. Self-assisted membrane-penetrating helical polypeptides mediate anti-inflammatory RNAi against myocardial ischemic reperfusion (IR) injury. Biomaterials Science, 2019, 7, 3717-3728.

2024 to present  Editor, Colloids and Surfaces B: Biointerfaces (IF: 5.8)

2024 to present  Early Career Editor, Research (IF: 11)

2024 to present  Early Career Editor, The Journal of Marine Science and Technology (IF: 10.8)

2023 Chinese Chemical Society Polymer Young Scholar Award (5 awardees per year)

2023 Advanced Materials (IF: 29.4) Rising Star

2022 Second Prize for Scientific Progress in Zhejiang Province (ranked fourth)

2021 Selected for the OuYueHai Smart Plan in Wenzhou City

2020 Double Innovation Doctor in Jiangsu Province

2019 National Outstanding Self-funded Study Abroad Scholarship (500 recipients globally each year)

2019 van de Mond Research Award in the Netherlands (ten slots annually in the Netherlands)

2018 Outstanding Contribution in Reviewing Award from the Journal of Colloid and Interface Science

2017 Outstanding Contribution in Reviewing Award from the Colloids and Surfaces B: Biointerfaces