李艳君

1. 线粒体在细胞蛋白质稳态维持过程中的组织调控作用。

2. 线粒体与细胞核之间相互作用研究。

3. 线粒体与神经退行性疾病。

1.Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Xu T, Liu L, Chen Q. A mitochondrial FUNDC1-HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO J. 2019 Feb 1;38(3). pii: e98786. doi: 10.15252/embj.201798786. Epub 2018 Dec 27.

2. Li Y, Zhao Y, Hu J, Xiao J, Qu L, Wang Z, Ma D, Chen Y. A novel ER-localized transmembrane protein, EMC6, interacts with Rab5 and regulates autophagy. Autophagy, 2013 February 1; 9(2): 150–163.  

3. Li Y, Chen Y^*. AMPK and Autophagy. Advances in Experimental Medicine and Biology, 2019, 1206: 85-108

4. Li Y, Liu L, Zhu Y, Chen Q^*. Mitochondria organize the cellular proteostatic response and promote cellular senescence. Cell Stress, 2019, 3(4): 110-114

5. Liu D, Wu H, Wang C, Li Y, Tian HB, Siraj S, Sehgal SA, Wang X, Wang J, Liu L, Shang Y, Jiang Z, Chen Q. STING directly avtivates autophagy to tune the innate immune response. Cell Death Differ. 2018 Dec 19. doi: 10.1038/s41418-018-0251-z. [Epub ahead of print]

6.  Li W, Li Y, Siraj S, Jin H, Fan Y, Yang X, Huang X, Wang X, Wang J, Liu L, Du L, Chen Q. FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation.Hepatology. 2018 Jul 27. doi: 10.1002/hep.30191. [Epub ahead of print] 

7. Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, Wang Y, Sehgal SA, Siraj S, Wang X, Wang J, Zhu Y, Chen Q. Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Rep. 2017 Mar;18(3):495-509.  

8. Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L, Chen Q. Mitophagy receptorFUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy. 2016;12(4):689-702.  

9. Chang Y, Li Y, Hu J, Guo J, Xu D, Xie H, Lv X, Shi T, Chen Y Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo. Cancer Letters, 2013 Jan 1;328(1):126-134

10. Tian S, Lin J, Zhou J, Wang X, Li Y, Ren X, Yu W, Zhong W, Xiao J, Sheng F, Chen Y, Jin C, Li S, Zheng Z, Xia B. Beclin 1-independent autophagy induced by a Bcl-X(L)/Bcl-2 targeting compound, Z18.Autophagy. 2010; 6(8):1032-1041

11. Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S, Zhao F, Ren X, Xiao J, Wang N, Liu S, Wang L, Sheng F, Chen Y, Jin C, Li S, Xia B. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells.Autophagy.2009 5(3):314-320