Liyanjun

In 2007, when I was enrolled in Masters, I visited Bin Xia’s lab in Peking University and started my work on the pharmacological study of compounds targeting Bcl-2, under the supervision of Associate Professor Jian Lin. In 2009, I joined Dalong Ma’s Lab in Peking University Health Science Center as a PhD student and started working on screening of the autophagy related proteins in mammalian cells. We found that ER-localized EMC6 can interact with Rab5 and promote the formation of autophagosomes in U2OS cells. In 2012, I joined in Quan Chen’s lab in Institute of Zoology, Chinese Academy of Science. There, I focused on the study of mitochondrial biology and found that mitochondria can contribute to the compensatory degradation of unfolded cytosolic proteins by employing their own proteases, or by organizing the formation and subsequent autophagic degradation of protein aggregates.

2009.9-2012.7 Peking University Health Science Center Doctor

2012.6-2019.3 Institute of Zoology, Chinese Academy of Science Postdoctor 2019.3-Present College of life sciences, Nankai University Associate professor

1. Organizng roles of mitochoondria in proteostasis maintenance.

2.Interactions between mitochondria and nucleus.

3. Mitochondria and neurodegenerative diseases.

1. Zhang Q, Sun T, Yu F, Liu W, Gao J, Chen J, Zheng H, Liu J, Miao C, Guo H, Tian W, Su M, Guo Y, Liu X, Pei Y, Wang Z, Chen S, Mu C, Lam SM, Shui G, Li Z, Yu Z, Zhang Y, Chen G, Lu C, Midgley AC, Li C, Bian X, Liao X, Wang Y, Xiong W, Zhu H, Li Y*, Chen Q*.  PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury, Nature Chemical Biology, 2024, 20:  835-846

2. Huang Y, Jin X, Zhang Y, Li Y, Liu J, Li Y*.  Innovative  methods for isolating highly purified mitochondria essential for biomedical studies.  Mitochondrial Communications, 2024, 2: 90-99   

3. Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Xu T, Liu L*, Chen Q*. A mitochondrial FUNDC1-HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO J. 2019 Feb 1,38(3). pii: e98786. doi: 10.15252/embj.201798786. Epub 2018 Dec 27.

4. Li Y, Zhao Y, Hu J, Xiao J, Qu L, Wang Z, Ma D, Chen Y. A novel ER-localized transmembrane protein, EMC6, interacts with Rab5 and regulates autophagy. Autophagy, 2013 February 1, 9(2): 150–163.  

5. Li Y, Chen Y^*. AMPK and Autophagy. Advances in Experimental Medicine and Biology, 2019, 1206: 85-108

6. Li Y, Liu L, Zhu Y, Chen Q^*. Mitochondria organize the cellular proteostatic response and promote cellular senescence. Cell Stress, 2019, 3(4): 110-114

7. Liu D, Wu H, Wang C, Li Y, Tian HB, Siraj S, Sehgal SA, Wang X, Wang J, Liu L, Shang Y, Jiang Z, Chen Q. STING directly avtivates autophagy to tune the innate immune response. Cell Death Differ. 2018 Dec 19.

8. Li W, Li Y, Siraj S, Jin H, Fan Y, Yang X, Huang X, Wang X, Wang J, Liu L, Du L, Chen Q. FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation. Hepatology. 2018 Jul 27.

9. Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, Wang Y, Sehgal SA, Siraj S, Wang X, Wang J, Zhu Y, Chen Q. Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Rep. 2017 Mar,18(3):495-509.  

10. Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L, Chen Q. Mitophagy receptorFUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy. 2016,12(4):689-702.  

11. Chang Y, Li Y, Hu J, Guo J, Xu D, Xie H, Lv X, Shi T, Chen Y Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo. Cancer Letters, 2013 Jan 1,328(1):126-134

12. Tian S, Lin J, Zhou J, Wang X, Li Y, Ren X, Yu W, Zhong W, Xiao J, Sheng F, Chen Y, Jin C, Li S, Zheng Z, Xia B. Beclin 1-independent autophagy induced by a Bcl-X(L)/Bcl-2 targeting compound, Z18. Autophagy. 2010, 6(8):1032-1041

13. Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S, Zhao F, Ren X, Xiao J, Wang N, Liu S, Wang L, Sheng F, Chen Y, Jin C, Li S, Xia B. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy. 2009 5(3):314-320