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宁文

性别: 女

部门: 遗传学和细胞生物学系

电话: 15822930529

办公地址: 生物楼108

职称: 教授

招生专业: 细胞生物学

邮箱: ningwen108@nankai.edu.cn

通讯地址:

个人简介

1984-1994年于南京大学生物系获博士学位,毕业后留校并聘为副教授,其间(1997-1998)在香港科技大学生物系做访问学者。2000-2005年在美国Pittsburgh 大学医学中心做博士后,主要从事吸烟与肺损伤和吸烟引起慢性阻塞性肺疾病(COPD)的分子机制的研究。2005年回国,受聘为南京大学模式动物研究所教授。2008年8月后受聘为南开大学生命科学院教授。2006年入选教育部新世纪优秀人才计划,现任中华医学会呼吸病学分会间质病学组副组长,中国医师协会呼吸医师分会研究工作委员会副主任委员。近年来,作为课题负责人参与国家973项目一项、国家重点研发计划项目二项和国家科技重大专项项目二项,广州实验室专项项目一项,主持国家自然科学基金重点项目一项和面上项目六项,天津市科委重点项目一项和面上项目一项;在J Exp Med,PNAS,Throax, Mol Thera, STTT, Sci Adv等国际学术刊物上发表论文近60余篇。

教育经历

工作经历

研究方向

主要研究内容为:1)肺泡和气管的发育及相关疾病2慢性气道损伤中干细胞与间质龛的相互作用3)纤维-免疫微环境的形成与肺纤维化发生发展4)生物药在纤维化疾病和炎症疾病中的潜在药用评价;



科研成果

代表论文:
1. Yingying Dong, Yan Geng, Lian Li, Xiaohe Li, Xiaohua Yan, Yinshan Fang, Xinxin Li, Siyuan Dong, Xue Liu, Xue Li, Xiuhong Yang, Xiaohong Zheng, Ting Xie, Jiurong Liang, Huaping Dai, Xinqi Liu, Zhinan Yin, Paul Noble, Dianhua Jiang* and Wen Ning* . Blocking Follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med, 2015. 212(2): 235-252 (*, corresponding author)
2. Yan Geng, Lian Li, YingYing Dong, Xue Liu, Xiaohe Li, Wen Ning*. Impaired Elastin Deposition in Fstl1–/– Lung Allograft under the Renal Capsule. PLoS ONE, 2013, 8(11): e81368  (*, corresponding author)
3. Lian Li, Xinxin Li, Xue Liu, Yingying Dong, Yan Geng, Xinqi Liu*, Wen Ning*  Expression, characterization, and preliminary X-ray crystallographic analysis of recombinant murine Follistatin-like 1 expressed in Drosophila S2 cells. BioScience Trends. 2013; 7(2):93-100. (*, corresponding author)
4. Yan Geng, Yingying Dong, Mingyan Yu, Long Zhang, Xiaohua Yan, Jingxia Sun, Long Qiao, Huixia Geng, Masahiro Nakajima, Tatsuya Furuichi, Shiro Ikegawa, Xiang Gao, Ye-Guang Chen*, Dianhua Jiang*, and Wen Ning*. Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lung Development. Proc Natl Acad Sci U S A.. 2011  108(17):7058-7063  (*, corresponding author)
5. Ning Shen, Tao Gong, Jian-Dong Wang, Fan-Li Meng, Long Qiao, Run-Lin Yang, Bin Xue, Fei-Yan Pan, Xiao-Jun Zhou, Hua-Qun Chen, Wen Ning*, Chaojun Li*. Cigarette Smoke–Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling. Am. J. Pathol. 2011 178(1): 110-118.                (*, corresponding author)
6. Ning W, Li CJ, Feghali-Bostwick CA, Matthay MA Choi AM. MAPK-EGR-1-HSP70 pathway regulates cigarette smoke induced chemokine release in human lung fibroblasts.Am J Physiol Lung Cell Mol Physiol. 2007 292(5):L1297-303
7. Ning W, Dong Y, Sun J, Li CJ, Feghali-Bostwick CA, Matthay MA Choi AM. Cigarette Smoke Stimulates Matrix Metalloproteinase Activity via EGR-1 in Human Lung Fibroblasts.  Am J Respir. Cell Mol. Biol. 2007 36(4):480-90.
8. Ning W, Peters DG, Chu TJ, Li C, Choi AM. Comparative SAGE Analysis of the Response to Hypoxia in Human Pulmonary and Aortic Endothelial Cells. Physiol Genomics. 2006 26(2):99-108
9. Ning W, Choi AM Li C. Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2005;289(2):L268-73.
10. Wen Ning, Chao-Jun Li and Augustine M.K. Choi.  Global Gene Expression Profiles Reveal Pathways Related to the Pathogenesis of Chronic Obstructive Pulmonary Disease. (2005) Discovery Medicine 5(25) :88-93
11. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JK, Sciurba FC, Peters DG, Hogg JC, Choi AM. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A.  2004 ;101(41):14895-900.)
12. Ning W, Chu TJ, Li CJ, Choi AM, Peters DG. Genome-wide analysis of the endothelial transcriptome under short-term chronic hypoxia. Physiol Genomics. 2004 ;18(1):70-8.
13. Ning W, Song R, Li C, Park E, Mohsenin A, Choi, Choi ME. TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 ;283(5):L1094-102. 

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