齐迹

齐迹，研究员、博士生导师，入选国家“四青”人才项目，南开大学百名青年学科带头人。现属于药物化学生物学国家重点实验室、生物活性材料教育部重点实验室和生命科学学院。2010年获得浙江大学学士学位，2015年博士毕业于中国科学院长春应用化学研究所，2016-2020年先后在香港科技大学唐本忠院士课题组，哈佛大学医学院Daniel Kohane和麻省理工学院Robert Langer院士团队进行博士后研究，2020年加入南开大学，组建独立研究课题组。实验室主要从事新型分子探针材料、纳米医学和生物医学工程的研究。迄今共发表SCI论文60多篇。以第一或通讯作者发表论文40余篇，其中包括影响因子大于15的研究论文20篇，如Nature Communications（4篇）、Chem、Advanced Materials（4篇）、Angewandte Chemie International Edition、ACS Nano（4篇）、Advanced Functional Materials（2篇）、Nano Today（2篇）、Biomaterials、Chemical Science等重要国际期刊，研究成果受到国内外同行专家的广泛关注，论文被引用4000余次。已授权或申请10项美国和中国发明专利，部分研究成果正在进行商业转化。目前主持国家海外高层次引进人才项目、国家自然科学基金面上项目、青年项目和天津市重点项目等。实验室诚招硕士研究生、博士研究生、博士后、科研助理等，欢迎联系申请。

2006.09 – 2010.06 浙江大学，本科；2010.09 – 2015.12 中国科学院长春应用化学研究所，硕博连读

2016.02-2019.01 香港科技大学，博士后（合作导师：唐本忠 中国科学院院士）；2019.01–2020.12 美国哈佛大学医学院、麻省理工学院，博士后（合作导师：Daniel Kohane，Robert Langer 美国国家科学院、医学院、工程院院士）；2020.12–今 南开大学，研究员、博导

1. 近红外有机分子探针与纳米药物递送；

2. 高分辨率活体精准成像和诊疗一体化；

3. 响应型多功能材料与生物医学应用。

部分代表性论文

1. Jianwen Song, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong*, Wen Li,* Ji Qi,* Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles. Nat. Commun. 2023, 14, 6881.

2. Xiaoying Kang, Yuan Zhang, Jianwen Song, Lu Wang, Wen Li*, Ji Qi*, Ben Zhong Tang*, A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy. Nat. Commun. 2023, 14, 5216.

3. Yuan Zhang, Xiaoying Kang, Jia Li, Jianwen Song, Xueping Li, Wen Li*, Ji Qi,* Inflammation-Responsive Nanoagents for Activatable Photoacoustic Molecular Imaging and Tandem Therapies in Rheumatoid Arthritis. ACS Nano 2024, 18, 2231–2249.

4. Yue Li, Zekun Du, Yuan Zhang, Xiaoying Kang, Jianwen Song, Xiaodong Chen, Yuanbo Hu, Zhimou Yang, Ji Qi*, Xian Shen*, Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy. Adv. Funct. Mater. 2024, 34, 2315127.

5. Ji Qi, Shaorui Jia, Xiaoying Kang, Xinying Wu, Yuning Hong, Ke Shan, Xianglong Kong, Zhiming Wang, Dan Ding, Semiconducting Polymer Nanoparticles with Surface-Mimicking Protein Secondary Structure As Lysosome-Targeting Chimaeras for Self-Synergistic Cancer Immunotherapy. Adv. Mater. 2022, 34, 2203309.

6. Heqi Gao, Xingchen Duan, Di Jiao, Yi Zeng, Xiaoyan Zheng,* Jingtian Zhang, Hanlin Ou, Ji Qi,* Dan Ding,* Boosting Photoacoustic Effect via Intramolecular Motions Amplifying Thermal-to-Acoustic Conversion Efficiency for Adaptive Image-Guided Cancer Surgery. Angew. Chem. Int. Ed. 2021, 60, 21047.

7. Ji Qi, Leyan Feng, Xiaoyan Zhang, Haoke Zhang, Liwen Huang, Yutong Zhou, Zheng Zhou, Zheng Zhao, Xingchen Duan, Fei Xu, Ryan T. K. Kwok, Jacky W. Y. Lam, Dan Ding, Xue Xue, Ben Zhong Tang, Facilitation of molecular motion in nanoparticles and development of turn-on photoacoustic bioprobe for in vivo detection of nitric oxide in encephalitis. Nat. Commun. 2021, 12, 960.

8. Ji Qi, Jun Li, Ruihua Liu, Qiang Li, Haoke Zhang, Jacky W. Y. Lam, Ryan T. K. Kwok, Dingbin Liu, Dan Ding, Ben Zhong Tang, Boosting Fluorescence-Photoacoustic-Raman Properties in One Fluorophore for Precise Cancer Surgery. Chem 2019, 5, 2657-2677.

9. Ji Qi, Chao Chen, Xiaoyan Zhang, Xianglong Hu, Shenglu Ji, Ryan T. K. Kwok, Jacky W. Y. Lam, Dan Ding, Ben Zhong Tang, Light-Driven Transformable Optical Agent with Adaptive Functions for Boosting Cancer Surgery Outcomes. Nat. Commun. 2018, 9, 1848. (ESI highly cited paper)

10. Ji Qi, Chaowei Sun, Abudureheman Zebibula, Hequn Zhang, Ryan T. K. Kwok, Xinyuan Zhao, Wang Xi, Jacky W. Y. Lam, Jun Qian, Ben Zhong Tang, Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region. Adv. Mater. 2018, 30, 1706856. (ESI highly cited paper)

11. Ji Qi, Yuan Fang, Ryan T. K. Kwok, Xiaoyan Zhang, Xianglong Hu, Jacky W. Y. Lam, Dan Ding, Ben Zhong Tang, Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice. ACS Nano 2017, 11, 7177-7188.

12. Ji Qi, Chaowei Sun, Dongyu Li, Hequn Zhang, Wenbin Yu, Abudureheman Zebibula, Jacky W. Y. Lam, Wang Xi, Liang Zhu, Fuhong Cai, Peifa Wei, Chunlei Zhu, Ryan T. K. Kwok, Lina L. Streich, Robert Prevedel, Jun Qian, Ben Zhong Tang, Aggregation-Induced Emission Luminogen with Near-Infrared-II Excitation and Near-Infrared-I Emission for Ultradeep Intravital Two-Photon Microscopy. ACS Nano 2018,12, 7936-7945.

13. Ji Qi, Nuernisha Alifu, Abudureheman Zebibula, Peifa Wei, Jacky W. Y. Lam, Hui-Qing Peng, Ryan T. K. Kwok, Jun Qian, Ben Zhong Tang, Highly Stable and Bright AIE Dots for NIR-II Deciphering of Living Rats. Nano Today 2020, 34, 100893.

14. Ji Qi, Xingchen Duan, Wenyi Liu, Ying Li, Yuanjing Cai, Jacky W. Y. Lam, Ryan T. K. Kwok, Dan Ding, Ben Zhong Tang, Dragonfly-Shaped Near-Infrared AIEgen with Optimal Fluorescence Brightness for Precise Image-Guided Cancer Surgery. Biomaterials 2020, 248, 120036.

15. Ji Qi, Xingchen Duan, Yuanjing Cai, Shaorui Jia,Chao Chen, Zheng Zhao, Ying Li, Hui-Qing Peng, Ryan T. K. Kwok, Jacky W. Y. Lam, Dan Ding, Ben Zhong Tang, Simultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens. Chem. Sci. 2020, 11, 8438-8447.

16. XiaoxiaoFan, Qiming Xia, Yiyin Zhang, Yirun Li, Zhe Feng, Jing Zhou, Ji Qi,* Ben Zhong Tang,* Jun Qian,* Hui Lin,* Aggregation-Induced Emission (AIE) Nanoparticles-Assisted NIR-II Fluorescence Imaging-Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD). Adv. Healthcare Mater. 2021, 10, 2101043.

17. Jingqin Chen,# Ji Qi,# Chao Chen,# Jianhai Chen, Liangjian Liu, Wenxiang Cheng, Qinchao Sun, Rongkang Gao, Tiantian Zhang, Liang Song, Dan Ding, Peng Zhang, Chengbo Liu, Tocilizumab-Conjugated Polymer Nanoparticles for NIR-II Photoacoustic Imaging-Guided Therapy of Rheumatoid Arthritis. Adv. Mater. 2020, 32, 202003399.

18. Zhe Feng,# Siyi Bai,# Ji Qi,# Chaowei Sun, Yuhuang Zhang, Xiaoming Yu, Huwei Ni, Di Wu, Xiaoxiao Fan, Dingwei Xue, Shunjie Liu, Ming Chen, Junyi Gong, Peifa Wei, Mubin He, Jacky W. Y. Lam, Xinjian Li, Ben Zhong Tang, Lixia Gao, Jun Qian, Biologically Excretable Aggregation-Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine. Adv. Mater. 2021, 33, 2008123.

19. Nuernisha Alifu,# Abudureheman Zebibula,# Ji Qi,# Hequn Zhang, Chaowei Sun, Xiaoming Yu, Dingwei Xue, Jacky W. Y. Lam, Gonghui Li, Jun Qian, Ben Zhong Tang, Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy. ACS Nano 2018, 12, 11282-11293.

20. XiaomingYu,# Yanyun Ying,# Zhe Feng,# Ji Qi,# Junyan Zheng, Yuhuang Zhang, Juan Liu, Jun Qian, Ben Zhong Tang, Dan Zhang, Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window. Nano Today 2021, 39, 101235.

21. Wen Li, Jingtian Zhang, Zhiyuan Gao, Ji Qi*, Dan Ding*, Advancing biomedical applications via manipulating intersystem crossing. Coordin. Chem. Rev. 2022, 471, 214754. (Invited Review)

22. Ji Qi, Chao Chen, Dan Ding, Ben Zhong Tang, Aggregation-Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare. Adv. Healthcare Mater. 2018, 7, 1800477. (Invited Review)

23. Ji Qi, Hanlin Ou, Qian Liu, Dan Ding, Gathering Brings Strength: How Organic Aggregates Boost Disease Phototheranostics. Aggregate 2021, 2, 95-113. (Invited Review)

24. Ji Qi, Xiaokang Zhou, Dezhi Yang, Wenqiang Qiao, Dongge Ma, Zhi Yuan Wang, Optimization of Solubility, Film Morphology and Photodetector Performance by Molecular Side-Chain Engineering of Low-Bandgap Thienothiadiazole-Based Polymers. Adv. Funct. Mater. 2014, 24, 7605-7612.

25. Ji Qi, Jinfeng Han, Xiaokang Zhou, Dezhi Yang, Jidong Zhang, Wenqiang Qiao, Dongge Ma, Zhi Yuan Wang, Optimization of Broad-Response and High-Detectivity Polymer Photodetectors by Bandgap Engineering of Weak Donor-Strong Acceptor Polymers. Macromolecules 2015, 48, 3941-3948.