科研:
在研项目:
1.“翻译后修饰在IFITM蛋白抗病毒功能中的作用及机制研究”(81571988, 2016-2019),国家自然科学基金面上项目,负责人;
2.“IRF-1抑制原型泡沫病毒复制机制研究”(31370182, 2014-2017),国家自然科学基金面上项目,负责人;
已结题主要项目:
1. “HIV 感染者的疾病进展与临床转归的关键生物学标志及新药靶的研究”(2012ZX10001-006,2012-2015),十二五重大专项课题,”细胞抗HIV作用机制及强化手段研究”任务负责人;
2. “艾滋病致病及免疫保护机理研究”(2008ZX10001-002,2008-2011),十一五重大专项课题,副组长;
3. “干扰素抗病毒效应与慢病毒潜伏感染活化的关系及机制研究”(2010CB534907,2010-1012),973前期计划课题,负责人;
4. “牛泡沫病毒无细胞感染性颗粒筛选”(2012-2013)国家留学基金委中德合作科研项目(PPP),负责人;
5. “牛泡沫病毒Bet蛋白功能及作用机制研究”(31070135,2011-2013),国家自然科学基金面上项目,负责人;
6. “IFP35抗泡沫病毒作用机制研究”(30770097,2009-2011),国家自然科学基金面上项目,负责人;
7. “新型动物慢病毒筛选抗AIDS药物模型的建立”(08JCZDJC21000,2008-2010),负责人;
8. “牛泡沫病毒BFV 3026 Borf1转录后调控研究”(30570072,2006-2008),负责人;
9. “艾滋病毒变异与流行和致病及免疫机制的研究”(2005CB522903,2006 -2010,研究骨干;
10. “HIV-及AIDS-相关疾病/肿瘤”( Fogarty International Center Training Program in HIV- and AIDS-Associated Diseases/Malignancies,5D43TW001429-07),美国国立卫生研究院(NIH)Fogarty国际培训项目,中方项目协调人。
另以主要参与人身份参与国家级基金及国际合作基金多项。
部分发表论文:
1. Li J, Yao Y, Chen Y, Xu X, Lin Y, Yang Z, Qiao W*, Tan J*. Enterovirus 71 3C Promotes Apoptosis through Cleavage of PinX1, a Telomere Binding Protein. J Virol. 2017,91(2). e02016-16
2. Ma J, Zhang X, Feng Y, Zhang H, Wang X, Zheng Y, Qiao W*, Liu X*. Structural and Functional Study of Apoptosis-linked Gene-2 Heme-binding Protein 2 Interactions in HIV-1 Production. J Biol Chem. 2016,291(52):26670-685
3. Liang Z, Liu R, Zhang H, Zhang S, Hu X, Tan J, Liang C, Qiao W*. GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription. Virology. 2016,493:1-11
4. Xu X, Qiu C, Zhu L, Huang J, Li L, Fu W, Zhang L, Wei J, Wang Y, Geng Y, Zhang X, Qiao W*, Xu J*. IFN-stimulated gene LY6E in monocytes regulates the CD14/TLR4 pathway but inadequately restrains the hyperactivation of monocytes during chronic HIV-1 infection. J Immunol. 2014,193(8):4125-36
5. Liu R, Lin Y, Jia R, Geng Y, Liang C, Tan J, Qiao W. HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1. Retrovirology. 2014,11:45
6. Jia R, Xu F, Qian J, Yao Y, Miao C, Zheng YM, Liu SL, Guo F, Geng Y, Qiao W*, Liang C*. Identification of an endocytic signal essential for the antiviral action of IFITM3. Cell Microbiol. 2014,16(7):1080-93
7. Jia R, Pan Q, Ding S, Rong L, Liu SL, Geng Y, Qiao W*, Liang C*. The N-Terminal Region of IFITM3 Modulates Its Antiviral Activity by Regulating IFITM3 Cellular Localization. J Virol. 2012;86: 13697-707
8. Wang J, Tan J, Guo H, Zhang Q, Jia R, Xu X, Geng Y*, Qiao W*. Bovine foamy virus transactivator btas interacts with cellular RelB to enhance viral transcription. J Virol. 2010;84:11888-897
9. Xuan C#, Qiao W#, Li J, Peng G, Liu M, Chen Q, Zhou J*, Geng Y. BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis. Cell Microbiol. 2008;10:31-40
10. Tan J#, Qiao W#, Wang J, Xu F, Li Y, Zhou J, Chen Q, Geng Y*. IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. J Virol. 2008;82:4275-4283
11. Deng G#, Qiao W#, Su Y, Sha R, Geng Y, Chen Q*. Internalization of jembrana disease virus Tat: Possible pathway and implication. Virus Res. 2006;121:122-33
12. Qiao W,Guo C, Zhang L, Chen Q. Geng Y*. cis-acting element located in the BFV internal promotert possesses the properties of a transcription enhancer. Chinese Science Bulletin. 2002: 47(13)
(注:* 通讯作者;# 共同第一作者)
专利:
1. 乔文涛等.以萤火虫萤光素酶为报告基因的BIV指示细胞系(专利号 ZL 2007 1 00576711.1)
2. 乔文涛等.以增强型绿色荧光蛋白为报告基因的BIV指示细胞系 (专利号 200710057672.6)