Jiandang Shi

Dr. Jiandang Shi, obtained his PhD in Virology in 2002 from Tianjin Medical University. He has been an Associate Professor at Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University since 2006. His research has been focused on the functions and mechanisms of higher order chromatin structure in regulating gene expression in stem cells and cancer. He also studied the role and mechanisms of steroid hormones, such as androgen and estrogen, in modulating gene expression in cancer. He has been the principal investigator of five scientific research projects, including three from National Natural Science Foundation of China (NSFC) and two form Tianjin Natural Science Foundation. He has participated in more than ten research projects from NSFC or 973 projects. To date, he has published more than 60 papers in the journals such as Sci Adv., Nucleic Acids Res., Cancer Lett., Cell Commun Signal., and Mol Cell Biol..

1990.09 ~ 1994.07 B.S., Department of Biochemistry and Molecular Biology, Nankai University 1996.09 ~ 1999.07 M.S., Department of Biochemistry, Tianjin Medical University 1999.09 ~ 2002.07 Ph.D candidate, Department of Microbiology, Tianjin Medical University

1994.07 ~ 1996.09 Asistant, Research Center of Tianjin Medical University 2002.10~ 2004.12 Postdoctor fellow, Collage of Life Sciences, Nankai University 2005.01~ 2006.05 Associate Professor, Research Center of Tianjin Medical University 2006.06~2019.12 Associate Professor, Collage of Life Sciences, Nankai University 2009.10~2011.09 Postdoc fellow, Markey Cancer Center, University of Kentucky 2019.12~ Professor, Collage of Life Sciences, Nankai University

1.Functions and mechanism of higher order chromatin structure in regulating gene expression in stem cells and cancer.

2.The role and mechanisms of steroid hormones, such as androgen and estrogen, in modulating gene expression in cancer.

1.    Wang Z, Liang Q, Qian X, Hu B, Zheng Z, Wang J, Hu Y, Bao Z, Zhao K, Zhou Y, Feng X, Yi X, Li J, Shi J, Liu Z, Hao J, Chen K, Yu Y, Sham P C, Lu W, Wang X, Song W, Li M J. 2023. An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Nat Commun. 2023; 14(1):1208.

2.    Tian L, Peng Y, Yang K, Cao J, Du X, Liang Z, Shi J*, Zhang J*. The ERα-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer. Cell Commun Signal. 2022; 20(1):178.  

3.    Bi J, Wang W, Zhang M, Zhang B, Liu M, Su G, Chen F, Chen B, Shi T, Zheng Y, Zhao X, Zhao Z, Shi J, Li P, Zhang L, Lu W. KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure. Nucleic Acids Res. 2022; 50(21):12235-12250.

4.    Lin Q, Cao J, Du X, Yang K, Yang X, Liang Z, Shi J*, Zhang J*. CYP1B1-catalyzed 4-OHE2 promotes the castration resistance of prostate cancer stem cells by estrogen receptor alpha-mediated IL6 activation[J]. Cell Commun Signal, 2022; 20(1):31.

5.    Lin Q, Cao J, Du X, Yang K, Shen Y, Wang W, Klocker H, Shi J*, Zhang J*. The HeyL-aromatase axis promotes cancer stem cell properties by endogenous estrogen-induced autophagy in castration-resistant prostate cancer. Front Oncol. 2022; 11:787953.

6.    Su G, Wang W, Zhao X, Chen J, Zheng J, Liu M, Bi J, Guo D, Chen B, Zhao Z, Shi J, Zhang L, Lu W. Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs. Nucleic Acids Res. 2021; 49(20):11575-11595.

7.    Chen B, He A, Bi J, Sun S, Ma Y, Wang W, Guo D, Chen J, Qian Y, Shi T, Nie G, Zhao Z, Shi J, Yang H, Zhang L, Lu W. Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide. J Genet Genomics. 2021; 48(10):946-949.

8.    Chen B, Ma Y, Bi J, Wang W, He A, Su G, Zhao Z, Shi J, Zhang L.Regulation Network of Colorectal-Cancer-Specific Enhancers in the Progression of Colorectal Cancer. Int J Mol Sci. 2021; 22(15):8337.

9.    Su G, Wang W, Chen J, Liu M, Zheng J, Guo D, Bi J, Zhao Z, Shi J, Zhang L, Lu W. CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA. J Biol Chem. 2021; 296:100413.

10.  Chen S, Chen B, Su G, Chen J, Guo D, Yin Q, Wang W, Zhao Z, Zhang L*, Shi J*, Lu W*. Branched-chain Amino Acid Aminotransferase-1 Regulates Self-Renewal and Pluripotency of Mouse Embryonic Stem Cells through Ras Signaling. Stem Cell Res. 2020; 49:102097.

11.  Zhang L, He A, Chen B, Bi J, Chen J, Guo D, Qian Y, Wang W, Shi T, Zhao Z, Shi J, An W, Attenello F, Lu W. A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes. Genome Res. 2020; 30(2):155-163.

12.  Liang Z, Cao J, Tian L, Shen Y, Yang X, Lin Q, Zhang R, Liu H, Du X, Shi J*, Zhang J*. Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-α/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer. Cancer Lett. 2019; 467:72-84. 

13.  Qian Y, Zhang L, Cai M, Li H, Xu H, Yang H, Zhao Z, Rhie S, Farnham P, Shi J*, Lu W*. The prostate cancer risk variant rs55958994 regulates multiple genes expression through extreme long-range chromatin interaction to control tumor progression. Sci. Adv. 2019; 5(7): eaaw6710. 

14.  Su G, Guo D, Chen J, Liu M, Zheng J, Wang W, Zhao X, Yin Q, Zhang L, Zhao Z, Shi J*, Lu W*. A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation. Nucleic Acids Res. 2019; pii: gkz482.

15.  Shen Y, Cao J, Liang Z, Lin Q, Wang J, Yang X, Zhang R, Zong J, Du X, Peng Y, Zhang J*, Shi J*. Estrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer. Cell Commun Signal. 2019; 17(1):50. 

16.  Shen Y, Gao Y, Yuan H, Cao J, Jia B, Li M, Peng Y, Du X, Zhang J*, Shi J*. Prohibitin-2 negatively regulates AKT2 expression to promote prostate cancer cell migration. Int J Mol Med. 2018; 41(2):1147-1155.  

17.  Moon BS, Bai J, Cai M, Liu C, Shi J, Lu W. Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis. Nat Commun. 2018; 9(1):401.

18.  Jia B, Gao Y, Li M, Shi J*, Peng Y, Du X, Klocker H, Sampson N, Shen Y, Liu M, Zhang J*. GPR30 Promotes Prostate Stromal Cell Activation via Suppression of ERα Expression and Its Downstream Signaling Pathway. Endocrinology. 2016; 157(8):3023-3035.

19.  Cai M, Gao F, Zhang P, An W, Shi J*, Wang K*, Lu W*. Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions. Sci Rep. 2015; 5:14558.  

20.  Shi J, Liu Y, Xu X, Zhang W, Yu T, Jia J, Liu C. Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling. Mol Cell Biol. 2015; pii: MCB.00373-15.

21.  Wang C, Du X, Yang R, Liu J, Xu D, Shi J*, Chen L, Shao R, Fan G, Gao X, Tian G, Zhu Y, Zhang J*. The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats. J Steroid Biochem Mol Biol. 2015; 145:28-37.

22.  Ning Z, Du X, Zhang J*, Yang K, Miao L, Zhu Y, Yuan H, Wang L, Klocker H, Shi J*. PGE2 modulates the transcriptional activity of ERRa in prostate stromal cells. Endocrine. 2014; 47(3):901-912.

23.  Mei S, Liu Y, Bao Y, Zhang Y, Min S, Liu Y, Huang Y, Yuan X, Feng Y, Shi J, Yang R. Dendritic cell-associated miRNAs are modulated via chromatin remodeling in response to different environments. PLoS One. 2014; 9(4):e90231.

24.  Shao R, Shi J*, Liu H, Shi X, Du X, Klocker H, Lee C, Zhu Y, Zhang J*. Epithelial-to-mesenchymal transition and estrogen receptor α mediated epithelial dedifferentiation mark the development of benign prostatic hyperplasia. Prostate. 2014; 74(9):970-984.

25.  Xu X, Yu T, Shi J, Chen X, Zhang W, Lin T, Liu Z, Wang Y, Zeng Z, Wang C, Li M, Liu C. Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. J Biol Chem. 2014; 289(13):8881-8890.

26.  Peng Y, Shi J*, Du X, Wang L, Klocker H, Mo L, Mo Z, Zhang J*. Prostaglandin E2 induces stromal cell-derived factor-1 expression in prostate stromal cells by activating protein kinase A and transcription factor Sp1. Int J Biochem Cell Biol. 2013; 45(3):521-530. 

27.  Miao L, Grebhardt S, Shi J*, Peipe I, Zhang J, Mayer D*. Prostaglandin E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein-beta in prostate cancer cells. Int J Biochem Cell Biol. 2012; 44(11):1919-1928.

28.  Yu L, Shi J*, Cheng S, Zhu Y, Zhao X, Yang K, Du X, Klocker H, Yang X, Zhang J*.Estrogen Promotes Prostate Cancer Cell Migration via Paracrine Release of ENO1 from Stromal Cells. Mol Endocrinol. 2012; 26(9):1521-1530.

29.  Yu T, Chen X, Zhang W, Colon D, Shi J, Napier D, Rychahou P, Lu W, Lee EY, Weiss HL, Evers BM, Liu C*.Regulation of the Potential Marker for Intestinal Cells, Bmi1, by beta-Catenin and the Zinc Finger Protein KLF4: Implications for Colon Cancer. J Biol Chem. 2012; 287(6):3760-3768.

 

He teaches “Biochemistry of Nucleic Acids” and “Experiment of Molecular Biology” for undergraduate students, and “Integrated Experiment of Biology” for graduate students.