Yuequan Shen

2000.5-2001.4 Brandeis University，Postdoctoral Fellow； 2001.5-2006.7 University of Chicago, Research Associate; 2006.7-2006.12 University of Chicago, Research Assistant Professor； 2006.12-present Nankai Univeristy, Professor

Structphysiology:

1) Calcium signaling;

2) Structure and Function of Calcium channels;

Selective publications:

1. Xing, Y., Wang, M., Wang, J., Nie, Z., Wu, G., Yang, X.*, Shen, Y.* (2019) Dimerization of MICU proteins controls Ca2+ influx through the mitochondrial Ca2+ uniporter. Cell Report. 26(5):1203-1212.

2. Wu, G., Yang, X.,Shen, Y.* (2018) Identification of a single aspartate residue critical for both fast and slow calcium-dependent inactivation of the human TRPML1 channel. J. Biol. Chem., 293(30):11736-11745

3. Li, X., Wu, G., Yang, Y., Fu, S., Liu, X., Kang, H., Yang. X.*, Su, X.*, Shen, Y.* (2017) Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers. Nat. Comm., 8(1), 1042. 10.1038/s41467-017-01135-w

4. Wang, L., Yang, X., Shen, Y.* (2015) Molecular mechanism of mitochondrial calcium uptake. Cell. Mol. Life Sci., 72(8), 1489-1498. Invited Review.

5. Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Xie, X., Wang, Z., Shen, Y.*, Long, J.* (2015) Dimerization of Elp1 is essential for Elongator complex assembly, Proc. Natl. Acad. Sci. USA, 112(34):10697-702.

6. Wang, L., Yang, X., Wang, Z., Liu, Y., Feng, J. Zhu, Y., Shen, Y.* (2014) Structural and Mechanistic Insights into MICU1 Regulation of Mitochondrial Calcium Uptake. EMBO J, 33(6), 594-604.

7. Xie, X., Yan, X., Wang, Z., Zhou, H., Diao, W., Zhou, W., Long, J.*,Shen, Y.* (2013) Open-Closed Motion of Mint2 Regulating APP Metabolism, J. Mol. Cell Biol., 5(1), 48-56.

8. Chu, X., Qin, X., Li, L., Wang, Z., Li, F., Zhou, H., Shen, Y.*, Long, J.* (2013) Structural insights into Paf1 complex assembly and histone binding. Nucleic Acid. Res. 41(22):10619-29.

9. Yang, X., Jin, H., Cai, X., Li, S., Shen, Y.* (2012) Structural and Mechanistic Insights into the Activation of STIM1, Proc. Natl. Acad. Sci. USA, 109(15), 5657–5662. (Selected by Faculty of 1000 Biology)

10. Wang, Z., Yang, X., Chu, X., Zhou, H., Shen, Y.*, Long J.* (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Res., 40(9):4193-202.

Structural Biology (graduate)

Biochemistry (undergraduate)

Protein function and technology (undergraduate)