Tanjuan

I have engaged in the molecular biology in retrovirus and related viruses for years and focuses on the interaction between the virus and host during infection. I aim to identify cellular factors that associate with HIV-1 Tat and Vpr proteins and to understand the functions of these factors in HIV-1 replication. I also aim to elucidate the mechanisms that explain why foamy virus can establish lifelong latent infections without accompanying pathology in its native hosts, and to provide reference for pathogenic retroviruses infection prevention and control of diseases. In recent years, I have received some grants from the Chinese Ministry of Health and National Natural Science Foundation of China. So far, I have published 44 papers. Among them, 19 SCI papers were published as the first or corresponding author, including 4 papers at Journal of Virology, 1 paper at Retrovirology, 1 paper at Veterinary Research and 5 papers at Virology.

1999-2003 B.S. in Biological Technology, Yangzhou University, Yangzhou, China 2003-2008 Ph.D. in Microbiology, Nankai University, Tianjin, China

06/2008-06/2010, Postdoctoral Fellow, Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin, China 07/2010-12/2010, Research Assistant, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China 01/2011-, Associate Professor, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China

Molecular biology of retroviruses and related viruses, Interactions between viruses and hosts

1.Lin Y, Wang Y, Li H, Chen Y, Qiao W, Xie Z*, Tan J*, Yang Z*. 2018. Simultaneous and systematic analysis of cellular and viral gene expression during Enterovirus 71-induced host shutoff. Protein Cell. [Epub ahead of print]

2.Xu X, Chai K, Chen Y, Lin Y, Zhang S, Li X, Qiao W*, Tan J*. 2018. Interferon activates promoter of Nmi gene via interferon regulator factor-1. Mol Cell Biochem. 441(1-2):165-71.

3.Li J, Yao Y, Chen Y, Xu X, Lin Y, Yang Z, Qiao W*, Tan J*. 2017. Enterovirus 71 3C Promotes Apoptosis through Cleavage of PinX1, a Telomere Binding Protein. J Virol. 91(2). pii: e02016-16.

4.Bing T, Zhang S, Liu X, Liang Z, Shao P, Zhang S, Qiao W, Tan J*. 2016. Important role of N108 residue in binding of bovine foamy virus transactivator Tas to viral promoters. Virol J. 13:117.

5.Zhang S, Cui X, Li J, Liang Z, Qiao W, Tan J*. 2016. Lysine residues K66, K109, and K110 in the bovine foamy virus transactivator protein are required for transactivation and viral replication. Virol Sin. 31(2):142-9.

6.Liu R, Lin Y, Jia R, Geng Y, Liang C, Tan J*, Qiao W*. 2014. HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1. Retrovirology. 11:45.

7.Hu X, Yang W, Liu R, Geng Y, Qiao W, Tan J*. 2014. N-Myc interactor inhibits prototype foamy virus by sequestering viral Tas protein in the cytoplasm. J Virol. 88(12):7036-44.

8.Ma Q^#, Tan J^#, Cui X, Luo D, Yu M, Liang C, Qiao W*. 2014. Residues R(199)H(200) of prototype foamy virus transactivator Bel1 contribute to its binding with LTR and IP promoters but not its nuclear localization. Virology. 449:215-23. (^#, co-first authors)

9.Liu R^#, Tan J^#, Lin Y, Jia R, Yang W, Liang C, Geng Y, Qiao W*. 2013. HIV-1 Vpr activates both canonical and noncanonical NF-κB pathway by enhancing the phosphorylation of IKKα/β. Virology. 439(1):47-56. (^#, co-first authors)

10.Guo HY, Ma YG, Gai YM, Liang ZB, Ma J, Su Y, Zhang QC, Chen QM, Tan J*. 2013. Bovine HEXIM1 inhibits bovine immunodeficiency virus replication through regulating BTat-mediated transactivation. Vet Res. 44:21.

11.Lei Y^#, Tan J^#, Wink M, Ma Y*, Li N, Su G. 2013. An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1. Food Chem. 136(3-4):1117-21. (^#, co-first authors)

12.Yang W^#, Tan J^#, Liu R, Cui X, Ma Q, Geng Y, Qiao W*. 2012. Interferon-γ upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1. PLoS One. 7(12):e50932. (^#, co-first authors)

13.Chang R^#, Tan J^#, Xu F, Han H, Geng Y, Li Y, Qiao W*. 2011. Lysine acetylation sites in bovine foamy virus transactivator BTas are important for its DNA binding activity. Virology. 418(1):21-6. (^#, co-first authors)

14.Xu F^#, Tan J^#, Liu R, Xu D, Li Y, Geng Y, Liang C, Qiao W*. 2011. Tetherin inhibits prototypic foamy virus release. Virol J. 8:198. (^#, co-first authors)

15.Wang J^#, Tan J^#, Guo H, Zhang Q, Jia R, Xu X, Geng Y*, Qiao W*. 2010. Bovine foamy virus transactivator BTas interacts with cellular RelB to enhance viral transcription. J Virol. 84(22):11888-97. (^#, co-first authors)

16.Tan J^#, Hao P^#, Jia R, Yang W, Liu R, Wang J, Xi Z, Geng Y, Qiao W*. 2010. Identification and functional characterization of BTas transactivator as a DNA-binding protein. Virology. 405(2):408-13. (^#, co-first authors)

17.Wang W^#, Tan J^#, Wang J, Chen Q, Geng Y, Qiao W*. 2010. Analysis of bovine foamy virus btas mRNA transcripts during persistent infection. Virus Genes. 40(1):84-93. (^#, co-first authors)

18.Tan J^#, Qiao W^#, Wang J, Xu F, Li Y, Zhou J, Chen Q, Geng Y*. 2008. IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus. J Virol. 82(9):4275-83. (^#, co-first authors)

19.Tan J^#, Qiao W^#, Xu F, Han H, Chen Q, Geng Y*. 2008. Dimerization of BTas is required for the transactivational activity of bovine foamy virus. Virology. 376(1):236-41. (^#, co-first authors)

Undergraduate courses:

2011-present Principle of gene manipulation

2012-present Comprehensive experiments of biotechnology 

2014-present Virology

Graduate courses:

2011-Present Principle of gene manipulation II

2012-present Molecular virology

2015-present Progress in molecular virology

2015-present literature review and opening report

2011-2013 Progress in molecular microbiology

2011-2014 Advances in microbiology