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Wuweihui |
Gender: male Department: 微生物学系 Tel: Office Location: Career: Professor Major: Microbiology Email: wuweihui@nankai.edu.cn Address: |
ResumeWeihui Wu obtained his BS and MS degrees in Microbiology from Nankai University, Tianjin, China, in 1998 and 2001, and Ph.D. degree from University Florida, Gainesville, Florida, the United States in 2006, in Immunology and Microbiology. He then did his postdoctoral trainings in M.D. Anderson Cancer Center in Houston (2006-2009) and Brigham and Women’s Hospital, Harvard Medical School in Boston (2009-2011). In 2011, he joined the faculty of Nankai University as a Professor of Microbiology.
Research in Wu laboratory is focused on bacteria caused infectious diseases. Currently, the bacteria under investigation in his laboratory is Pseudomonas aeruginosa, which is an opportunistic pathogen causing a variety of infections. His laboratory is mainly working on mechanisms whereby the bacterium cause disease and antibiotic resistance, as well as host pathogen interaction and vaccine development.
Education1994-1998 B.S. in Microbiology Nankai University, Tianjin, China
1998-2001 M.S. in Microbiology Nankai University, Tianjin, China
2001-2006 Ph.D. in Immunology and Microbiology, University of Florida, Gainesville, FL, USA
WorkExperience10/2006-6/2009, Postdoctoral Fellow, Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. Mentor: Dr. Xin Lin
7/2009-8/2011, Postdoctoral Fellow, Channing Lab, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. Mentor: Dr. Gregory Priebe
9/2011-present, Professor, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China
Research FieldsRegulation and function of pathogenic bacterial virulence factors Mechanisms of antibiotics resistance in pathogenic bacteria Host immune responses during infection Achievement
1. Pan X, Liang H, Zhao X, Zhang Q, Chen L, Yue Z, Yin L, Jin Y, Bai F, Cheng Z, Bartlam M, Wu W. Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa. (2023) Nucleic Acids Res. 2023 Feb 6:gkad059. doi: 10.1093/nar/gkad059. 2. Chen H, Gong X, Fan Z, Xia Y, Jin Y, Bai F, Cheng Z, Pan X, Wu W. Pseudomonas aeruginosa Citrate Synthase GltA Influences Antibiotic Tolerance and the Type III Secretion System through the Stringent Response. (2023) Microbiol Spectr. e0323922. 3. Liu Q, Yin L, Lv C, Bai F, Cheng Z, Wu W, Jin Y. Parallel Evolution to Elucidate the Contributions of PA0625 and parE to Ciprofloxacin Sensitivity in Pseudomonas aeruginosa. (2022) Microorganisms. 11(1):13. 4. Long X, Wang X, Mao D, Wu W, Luo Y. A Novel XRE-Type Regulator Mediates Phage Lytic Development and Multiple Host Metabolic Processes in Pseudomonas aeruginosa. (2022) Microbiol Spectr. 10(6):e0351122. 5. Gao C, Chen Y, Cheng X, Zhang Y, Zhang Y, Wang Y, Cui Z, Liao Y, Luo P, Wu W, Wang C, Zeng H, Zou Q, Gu J. A novel structurally identified epitope delivered by macrophage membrane-coated PLGA nanoparticles elicits protection against Pseudomonas aeruginosa. (2022) J Nanobiotechnology. 20(1):532 6. Zhao X, Jin Y, Bai F, Cheng Z, Wu W, Pan X. Pseudomonas aeruginosa Phosphate Transporter PitA (PA4292) Controls Susceptibility to Aminoglycoside Antibiotics by Regulating the Proton Motive Force. (2022) Antimicrob Agents Chemother. 66(12):e0099222. 7. Yang F, Zhou Y, Chen P, Cai Z, Yue Z, Jin Y, Cheng Z, Wu W, Yang L, Ha UH, Bai F. High-Level Expression of Cell-Surface Signaling System Hxu Enhances Pseudomonas aeruginosa Bloodstream Infection. (2022) Infect Immun. 90(10):e0032922. 8. Long X, Zhang H, Wang X, Mao D, Wu W, Luo Y. RecT Affects Prophage Lifestyle and Host Core Cellular Processes in Pseudomonas aeruginosa. (2022) Appl Environ Microbiol. 88(18):e0106822. 9. Gao J, Hu X, Xu C, Guo M, Li S, Yang F, Pan X, Zhou F, Jin Y, Bai F, Cheng Z, Wu Z, Chen S, Huang X, Wu W. Neutrophil-mediated delivery of the combination of colistin and azithromycin for the treatment of bacterial infection. (2022) iScience. 25(9):105035. 10. Gao J, Wei X, Yin L, Jin Y, Bai F, Cheng Z, Wu W. Emergence and Transfer of Plasmid-Harbored rmtB in a Clinical Multidrug-Resistant Pseudomonas aeruginosa Strain. (2022) Microorganisms. 10(9):1818. 11. Xu C, Wei X, Jin Y, Bai F, Cheng Z, Chen S, Pan X, Wu W. Development of Resistance to Eravacycline by Klebsiella pneumoniae and Collateral Sensitivity-Guided Design of Combination Therapies. (2022) Microbiol Spectr. 10(5):e0139022. 12. Zhao X, Jin Y, Bai F, Cheng Z, Wu W, Pan X. Mutation of PA4292 in Pseudomonas aeruginosa Increases β-Lactam Resistance through Upregulating Pyocyanin Production. (2022) Antimicrob Agents Chemother. 66(7):e0042122. 13. Li S, Gong X, Yin L, Pan X, Jin Y, Bai F, Cheng Z, Ha UH, Wu W. Acetylation of CspC Controls the Las Quorum-Sensing System through Translational Regulation of rsaL in Pseudomonas aeruginosa. (2022) mBio. 13(3):e0054722. 14. Li H, Xia Y, Tian Z, Jin Y, Bai F, Cheng Z, Swietnicki W, Wu W, Pan X. Dihydrolipoamide Acetyltransferase AceF Influences the Type III Secretion System and Resistance to Oxidative Stresses through RsmY/Z in Pseudomonas aeruginosa. (2022) Microorganisms. 10(3):666. 15. Pan X, Zhao X, Song Y, Ren H, Tian Z, Liang Q, Jin Y, Bai F, Cheng Z, Feng J, Wu W. Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate. (2022) Microbiol Spectr. 10(1):e0267821. 16. Zhang X, Yin L, Liu Q, Wang D, Xu C, Pan X, Bai F, Cheng Z, Wu W, Jin Y. NrtR Mediated Regulation of H1-T6SS in Pseudomonas aeruginosa. (2022) Microbiol Spectr. 10(1):e0185821. 17. Cai Z, Yang F, Shao X, Yue Z, Li Z, Song Y, Pan X, Jin Y, Cheng Z, Ha UH, Feng J, Yang L, Deng X, Wu W, Bai F. ECF Sigma Factor HxuI Is Critical for In Vivo Fitness of Pseudomonas aeruginosa during Infection. (2022) Microbiol Spectr. 10(1):e0162021. 18. Yang B, Jiang Y, Jin Y, Bai F, Cheng Z, Wu W. Pseudomonas aeruginosa Oligoribonuclease Controls Susceptibility to Polymyxin B by Regulating Pel Exopolysaccharide Production. (2022) Antimicrob Agents Chemother. 66(3):e0207221. 19. Wang D, Zhang X, Yin L, Liu Q, Yu Z, Xu C, Ma Z, Xia Y, Shi J, Gong Y, Bai F, Cheng Z, Wu W, Lin J, Jin Y. RplI interacts with 5' UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa. (2022) PLoS Pathog. 18(1):e1010170. 20. Duan N, Ma X, Cui H, Wang Z, Chai Z, Yan J, Li X, Feng Y, Cao Y, Jin Y, Bai F, Wu W, Rikihisa Y, Cheng Z. Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen Ehrlichia chaffeensis. (2021) Emerg Microbes Infect. 10(1):461-471. 21. Cebrián R, Xu C, Xia Y, Wu W, Kuipers OP. The cathelicidin-derived close-to-nature peptide D-11 sensitises Klebsiella pneumoniae to a range of antibiotics in vitro, ex vivo and in vivo. (2021) Int J Antimicrob Agents. 58(5):106434. 22. Xia Y, Cebrián R, Xu C, Jong A, Wu W, Kuipers OP. Elucidating the mechanism by which synthetic helper peptides sensitize Pseudomonas aeruginosa to multiple antibiotics. (2021) PLoS Pathog. 17(9):e1009909. 23. Li S, Weng Y, Li X, Yue Z, Chai Z, Zhang X, Gong X, Pan X, Jin Y, Bai F, Cheng Z, Wu W. Acetylation of the CspA family protein CspC controls the type III secretion system through translational regulation of exsA in Pseudomonas aeruginosa. (2021) Nucleic Acids Res. 49(12): 6756–6770. 24. Ren H, Zhang J, Zhou J, Xu C, Fan Z, Pan X, Li S, Liang Y, Chen S, Xu J, Wang P, Zhang Y, Zhu G, Liu H, Jin Y, Bai F, Cheng Z, Pletzer D, Wu W. Synergistic bactericidal activities of tobramycin with ciprofloxacin and azithromycin against Klebsiella pneumoniae. (2021) J Antibiot (Tokyo). 74(8):528-537. 25. Zhou J, Li S, Li H, Jin Y, Bai F, Cheng Z, Wu W. Identification of a Toxin-Antitoxin System That Contributes to Persister Formation by Reducing NAD in Pseudomonas aeruginosa. (2021) Microorganisms. 9(4):753. 26. Yang B, Liu C, Pan X, Fu W, Fan Z, Jin Y, Bai F, Cheng Z, Wu W. Identification of Novel PhoP-PhoQ Regulated Genes That Contribute to Polymyxin B Tolerance in Pseudomonas aeruginosa. (2021) Microorganisms. 9(2):344. 27. Fan Z, Pan X, Wang D, Chen R, Fu T, Yang B, Jin Y, Bai F, Cheng Z, Wu W. Pseudomonas aeruginosa Polynucleotide Phosphorylase Controls Tolerance to Aminoglycoside Antibiotics by Regulating the MexXY Multidrug Efflux Pump. (2021) Antimicrob Agents Chemother. 65(2):e01846-20. 28. Li Q, Cebrián R, Montalbán-López M, Ren H, Wu W, Kuipers OP. Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens. (2021) Commun Biol. 4(1):31. 29. Xia Y, Xu C, Wang D, Weng Y, Jin Y, Bai F, Cheng Z, Kuipers OP, Wu W. YbeY controls the type III and type VI secretion systems and biofilm formation through RetS in Pseudomonas aeruginosa. (2020) Appl Environ Microbiol. AEM.02171-20. 30. Xia Y, Weng Y, Xu C, Wang D, Pan X, Tian Z, Xia B, Li H, Chen R, Liu C, Jin Y, Bai F, Cheng Z, Kuipers OP, Wu W. Endoribonuclease YbeY Is Essential for RNA Processing and Virulence in Pseudomonas aeruginosa. (2020) mBio. 11(3):e00659-20. 31. Pan X, Fan Z, Chen L, Liu C, Bai F, Wei Y, Tian Z, Dong Y, Shi J, Chen H, Jin Y, Cheng Z, Jin S, Lin J, Wu W. PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids. (2020) Nucleic Acids Res. 48(11):5967-5985. 32. Long Y, Fu W, Wang S, Deng X, Jin Y, Bai F, Cheng Z, Wu W. Fis Contributes to Resistance of Pseudomonas aeruginosa to Ciprofloxacin by Regulating Pyocin synthesis. (2020) J Bacteriol. 202(11):e00064-20. 33. Xia Y, Wang D, Pan X, Xia B, Weng Y, Long Y, Ren H, Zhou J, Jin Y, Bai F, Cheng Z, Jin S, Wu W. TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in Pseudomonas aeruginosa. (2020) mBio. 11(1). pii: e02079-19. 34. Tian Z, Cheng S, Xia B, Jin Y, Bai F, Cheng Z, Jin S, Liu X, Wu W. Pseudomonas aeruginosa ExsA regulates a metalloprotease ImpA that inhibits phagocytosis of macrophages. (2019) Infect Immun. Sep 16. pii: IAI.00695-19. 35. Ren H, Liu Y, Zhou J, Long Y, Liu C, Xia B, Shi J, Fan Z, Liang Y, Chen S, Xu J, Wang P, Zhang Y, Zhu G, Liu H, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Combination of Azithromycin and Gentamicin for Efficient Treatment of Pseudomonas aeruginosa Infections. (2019) J Infect Dis. 220(10):1667-1678. 36. Fan Z, Chen H, Li M, Pan X, Fu W, Ren H, Chen R, Bai F, Jin Y, Cheng Z, Jin S, Wu W. Pseudomonas aeruginosa Polynucleotide Phosphorylase Contributes to Ciprofloxacin Resistance by Regulating PrtR. (2019) Front Microbiol. Jul 30;10:1762. 37. Feng C, Huang Y, He W, Cheng X, Liu H, Huang Y, Ma B, Zhang W, Liao C, Wu W, Shao Y, Xu D, Su Z, Lu W. Tanshinones: First-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy. (2019) ACS Cent Sci. 5(7):1278-1288. 38. Li S, Lou X, Xu Y, Teng X, Liu R, Zhang Q, Wu W, Wang Y, Bartlam M. Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. (2019) FEBS J. Jul 11. doi: 10.1111/febs.14995. 39. Long Y, Fu W, Li S, Ren H, Li M, Liu C, Zhang B, Xia Y, Fan Z, Xu C, Liu J, Jin Y, Bai F, Cheng Z, Liu X, Jin S, Wu W. Identification of novel genes that promote persister formation by repressing transcription and cell division in Pseudomonas aeruginosa. (2019) J Antimicrob Chemother. May 28. pii: dkz214. doi: 10.1093/jac/dkz214. 40. Chen R, Wei X, Li Z, Weng Y, Xia Y, Ren W, Wang X, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Identification of a small RNA that directly controls the translation of the quorum sensing signal synthase gene rhlI in Pseudomonas aeruginosa. (2019) Environ Microbiol. May 20. doi: 10.1111/1462-2920.14686. 41. Xia B, Li M, Tian Z, Chen G, Liu C, Xia Y, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Oligoribonuclease Contributes to Tolerance to Aminoglycoside and β-Lactam Antibiotics by Regulating KatA in Pseudomonas aeruginosa. (2019) Antimicrob Agents Chemother. 63(6). pii: e00212-19. 42. Jin Y, Zhang M, Zhu F, Peng Q, Weng Y, Zhao Q, Liu C, Bai F, Cheng Z, Jin S, Wu W. NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa. (2019) Front Microbiol. 10:85. 43. Song D, Meng J, Cheng J, Fan Z, Chen P, Ruan H, Tu Z, Kang N, Li N, Xu Y, Wang X, Shu F, Mu L, Li T, Ren W, Lin X, Zhu J, Fang X, Amrein MW, Wu W, Yan LT, Lü J, Xia T, Shi Y. Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution. (2019) Nat Microbiol. 4(1):97-111. 44. Zhang Y, Xia B, Li M, Shi J, Long Y, Jin Y, Bai F, Cheng Z, Jin S, Wu W. HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa. (2018) Toxins (Basel). 10(11). 45. Liu C, Pan X, Xia B, Chen F, Jin Y, Bai F, Priebe G, Cheng Z, Jin S, Wu W. Construction of a Protective Vaccine Against Lipopolysaccharide-Heterologous Pseudomonas aeruginosa Strains Based on Expression Profiling of Outer Membrane Proteins During Infection. (2018) Front Immunol. 9:1737. 46. Fan Z, Xu C, Pan X, Dong Y, Ren H, Jin Y, Bai F, Cheng Z, Jin S, Wu W. Mechanisms of RsaL mediated tolerance to ciprofloxacin and carbenicillin in Pseudomonas aeruginosa. (2018) Curr Genet. Jun 27. doi: 10.1007/s00294-018-0863-3. 47. You J, Sun L, Yang X, Pan X, Huang Z, Zhang X, Gong M, Fan Z, Li L, Cui X, Jing Z, Jin S, Rao Z, Wu W, Yang H. Regulatory protein SrpA controls phage infection and core cellular processes in Pseudomonas aeruginosa. (2018) Nat Commun. 9(1):1846. 48. Shi J, Liu Y, Zhang Y, Jin Y, Bai F, Cheng Z, Jin S, Wu W. PA5470 Counteracts Antimicrobial Effect of Azithromycin by Releasing Stalled Ribosome in Pseudomonas aeruginosa. (2018) Antimicrob Agents Chemother. Jan 25;62(2). 49. He C, Zhou Y, Liu F, Liu H, Tan H, Jin S, Wu W, Ge B. Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation. (2017) Infect Immun. Aug 18;85(9). 50. Li K, Yang G, Debru AB, Li P, Zong L, Li P, Xu T, Wu W, Jin S, Bao Q. SuhB Regulates the Motile-Sessile Switch in Pseudomonas aeruginosa through the Gac/Rsm Pathway and c-di-GMP Signaling. (2017) Front Microbiol. 8:1045. 51. Deng X, Li M, Pan X, Zheng R, Liu C, Chen F, Liu X, Cheng Z, Jin S, Wu W. Fis Regulates Type III Secretion System by Influencing the Transcription of exsA in Pseudomonas aeruginosa Strain PA14. (2017) Front Microbiol. 8:669 52. Pan X, Dong Y, Fan Z, Liu C, Xia B, Shi J, Bai F, Jin Y, Cheng Z, Jin S and Wu W. In vivo host environment alters Pseudomonas aeruginosa susceptibility to aminoglycoside antibiotics. (2017) Front. Cell. Infect. Microbiol.14;7:83. 53. Chen F, Chen G, Liu Y, Jin Y, Cheng Z, Liu Y, Yang L, Jin S, Wu W. Pseudomonas aeruginosa oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis. (2017) Antimicrob Agents Chemother. 61(3):e02256-16 54. Weng Y, Chen F, Liu Y, Zhao Q, Chen R, Pan X, Liu C, Cheng Z, Jin S, Jin Y, Wu W. Pseudomonas aeruginosa Enolase Influences Bacterial Tolerance to Oxidative Stresses and Virulence. (2016) Front Microbiol. 15;7:1999. 55. Li M, Long Y, Liu Y, Liu Y, Chen C, Shi J, Zhang L, Jin Y, Yang L, Bai F, Jin S, Cheng Z, Wu W. HigB of Pseudomonas aeruginosa Enhances Killing of Phagocytes by Up-Regulating the Type III Secretion System in Ciprofloxacin Induced Persister Cells. (2016) Front. Cell. Infect. Microbiol. 6:125. 56. Chen G, Zhao Q, Zhu F, Chen R, Jin Y, Liu C, Pan X, Jin S, Wu W, Cheng Z. Oligoribonuclease is required for the type III secretion system and pathogenesis of Pseudomonas aeruginosa. (2016) Microbiol Res. 188-189:90-6. 57. Tan H, Zhang L, Zhao Q, Chen R, Liu C, Weng Y, Peng Q, Bai F, Cheng Z, Jin S, Wu W, Jin Y. DeaD contributes to Pseudomonas aeruginosa virulence in a mouse acute pneumonia model. (2016) FEMS Microbiol Lett. Oct;363(20). 58. Tan H, Zhang L, Weng Y, Chen R, Zhu F, Jin Y, Cheng Z, Jin S, Wu W. PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa. (2016) Front Microbiol.7:317. 59. Chen R, Weng Y, Zhu F, Jin Y, Liu C, Pan X, Xia B, Cheng Z, Jin S, Wu W. Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa. (2016) Front Microbiol. 2;7:247. 60. Guo Q, Wei Y, Xia B, Jin Y, Liu C, Pan X, Shi J, Zhu F, Li J, Qian L, Liu X, Cheng Z, Jin S, Lin J, Wu W. Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa. (2016) Sci Rep. 6:19141. 61. Jin Y, Jin S, Wu W. Regulation of bacterial gene expression by ribosome stalling and rescuing.(2015) Curr Genet. Nov 26 62. Shi J, Jin Y, Bian T, Li K, Sun Z, Cheng Z, Jin S, Wu W. SuhB is a novel ribosome associated protein that regulates expression of MexXY by modulating ribosome stalling in Pseudomonas aeruginosa. (2015) Mol Microbiol. 98(2):370-83. 63. Bai F, Ho Lim C, Jia J, Santostefano K, Simmons C, Kasahara H, Wu W, Terada N, Jin S. Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors. (2015) Sci Rep.5:15014. 64. Jia J, Bai F, Jin Y, Santostefano KE, Ha UH, Wu D, Wu W, Terada N, Jin S. Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins. (2015) Stem Cells Transl Med.;4(8):913-26. 65. Neeld D, Jin Y, Bichsel C, Jia J, Guo J, Bai F, Wu W, Ha UH, Terada N, Jin S. Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system. (2014) Microbiology. 160(Pt 7):1417-26. 66. Jia J, Jin Y, Bian T, Wu D, Yang L, Terada N, Wu W, Jin S. (2014) Bacterial delivery of TALEN proteins for human genome editing. PLoS One. 11;9(3):e91547. 67. Sun Z, Shi J, Liu C, Jin Y, Li K, Chen R, Jin S, Wu W. PrtR homeostasis contributes to Pseudomonas aeruginosa pathogenesis and resistance against ciprofloxacin. (2014) Infect Immun. 82(4):1638-47. 68. Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, Jin S, Wu W. SuhB is a regulator of multiple virulence genes and essential for pathogenesis of Pseudomonas aeruginosa.(2013) MBio. 4(6):e00419-13. 69. Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. (2013) J Infect Dis. 207(1):39-49. 70. Wu, W, J Huang, B Duan, DC Traficante, H Hong, M Risech, S Lory, GP Priebe. Th17-stimulating Protein Vaccines Confer Protection against Pseudomonas aeruginosa Pneumonia. (2012) Am J Respir Crit Care Med. 186(5):420-7. 71. Bi, L., S. Gorjestani, W. Wu, YM. Hsu, J. Zhu, K. Ariizumi, X. Lin. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 20;285(34):25969-77. 72. Wu, W., YM. Hsu, L. Bi, Z. Songyang, X. Lin. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 10(11):1208-14. 73. Ha, U., J-H. Lim, W. Wu, S. Jin and J-D. Li. (2008) MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 283(45):30624-31. 74. Yang, H., Z. Shan, J. Kim, W. Wu, W. Lian, L. Zeng, L. Xing and S. Jin. (2007) Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa. J Bacteriol. 189(7):2599-609. 75. Jyot, J., A. Sonawane, W. Wu and R. Ramphal. (2007) Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol. 63(4):1026-38. 76. Wu, W. and S. Jin. (2005) PtrB of Pseudomonas aeruginosa Suppresses Type III Secretion System Under the Stress of DNA Damage. J Bacteriol. 187(17):6058-68. 77. Wu, W., Y. Song, S. Jin and S. Chen. (2006) An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome. Systems Biology and Regulatory Genomics of Lecture Notes in Computer Science. 4023: 1-10. 78. Wu, W., H. Badrane, S. Arora, H. Baker and S. Jin. (2004) MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol. 186(22):7575-85. Social AppointmentsTeaching Experience2013-Present Undergraduate course Microbial Genetics 2015-Present Undergraduate course Microbiology Honor Title |
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