王永健

王永健，南开大学生命科学学院教授，博士生导师。1988年、1994年和1999年于南开大学分别获得学士、硕士和博士学位。1999-2001年在天津大学从事生物化工方面的博士后研究。2001年至今在南开大学生命科学学院工作，从事生物医学材料方面的研究。2011-2012年作为visiting professor在美国Utah University从事药物递送方面的研究。获得国家科学技术进步奖二等奖。

1999年，博士毕业于南开大学高分子化学研究所（导师：何炳林院士） 1994年，硕士毕业于南开大学高分子化学研究所（导师：何炳林院士） 1988年，本科毕业于南开大学化学系

2001年至今，南开大学，生命科学学院 1999-2001年，天津大学，博士后（合作导师：孙彦教授）

课题组主要研究方向包括：

1) 肿瘤和心血管疾病治疗用纳米药物递送系统；

2) 血液净化吸附材料；

3) 组织修复材料。

(1)      Runze Zhao, Xiaoyue Ning, Mengqi Wang, Huanhuan Wang, Guang Xing, Li Wang, Chengzhi Lu, Ao Yu and Yongjian Wang, A ROS-Responsive Simvastatin Nano-Prodrug and its Fibronectin-Targeted co-Delivery System for Atherosclerosis Treatment, ACS Applied Materials & Interfaces, 2022, 14(22): 25080–25092

(2)      Huanhuan Wang, Xiaoyue Ning, Xinnan Wang, Fei Ding, Yongjian Wang, A versatile modular preparation strategy for targeted drug delivery systems against multidrug-resistant cancer cells, Nanotechnology, 2022,33(5): 055101

(3)      Runze Zhao, Xiaoyue Ning, Mengqi Wang, Ao Yu and Yongjian Wang, A multifunctional nano-delivery system enhances the chemo-co-phototherapy of tumor multidrug resistance via mitochondrial-targeting and inhibiting P-glycoprotein-mediated efflux, Journal of Materials Chemistry B, 2021, 9(44), 9174-9182

(4)      Li Wang, Yunfan Peng, Lijun Song, Dasheng Xia, Chao Li, Zhuqing Li, Qi Li, Ao Yu, Chengzhi Lu and Yongjian Wang. Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation. Cardiovascular Drugs and Therapy 2021. https://doi.org/10.1007/s10557-021-07239-2

(5)      Chenxu Zhang, Shihui Li, Ao Yu and Yongjian Wang, Nano CaCO3 “Lysosomal Bombs” Enhance Chemotherapy Drug efficacy via Rebalancing Tumor Intracellular pH, ACS Biomaterials Science & Engineering, 2019, 5(7): 3398-3408

(6)      Xueming Lv, Yiyong Zhu, Hamid Ghandehari, Ao Yu and Yongjian Wang, An ROS-responsive and self-accelerating drug release nanoplatform for overcoming multidrug resistance, Chemical Communications, 2019, 55(23): 3383-3386

(7)      Dandan Sun, Xueming Lv, Xinnan Wang, Ao Yu, Yongjian Wang, Mixed micelles based on a pH-sensitive prodrug and TPGS for enhancing drug efficacy against multidrug-resistant cancer cells, Colloids and Surfaces B: Biointerfaces, 2017, 159: 419-426

(8)      Chao Zhu, Xueting Yan, Ao Yu and Yongjian Wang, Doxycycline synergizes with doxorubicin to inhibit proliferation of castration-resistant prostate cancer cells, Acta Biochimica et Biophysica Sinica, 2017, 49(11): 999-1007

(9)      Shu Peng, Yu-Chen Pan, Yaling Wang, Zhe Xu, Chao Chen, Dan Ding, Yongjian Wang, Dong-Sheng Guo, Sequentially Programmable and Cellularly Selective Assembly for Thermochromic Fluorescent Polymerized Vesicles: from Inanimate Environments to Living Cells, Advanced Science, 2017: 1700310

(10)   Baolong Xie, Fufeng Liu, Xiaoyan Dong, Yongjian Wang, Xiaoguang Margaret Liu, Yan Sun, Modulation effect of acidulated human serum albumin on Cu²⁺-mediated amyloid beta-protein aggregation and cytotoxicity under a mildly acidic condition, Journal of Inorganic Biochemistry, 2017, 171: 67-75

讲授研究生课程：

《现代生物学技术》、《生物分离与检测技术》

讲授本科生课程：

《现代生物技术与应用》、《化工原理》