Yangjun

She received her B.S. and M.S. in Polymer Chemistry from Tianjin University (China), and then received her PhD degree in Biotechnology from Tokyo Institute of Technology (Japan) in Sept. 2001. Her research interest is the construction of extracellular microenvironment with bioactive materials for controlling cell adhesion, proliferation, migration, differentiation and tissue regeneration. She has been working for development of novel functionalized biomaterials for various applications in liver / blood vessel tissue engineering, cell bioreactor and drug / gene delivery system.

Apr 1998 – Sep 2001 PhD in Biotechnology at Tokyo Institute of Technology, Japan Sep 1994 – Mar 1997 MESc in Polymer Materials at Tianjin University, China Sep 1986 – Jul 1990 BESc in Polymer Chemistry Engineering at Tianjin University, China

Dec 2005 – present Professor at the key laboratory of bioactive materials Ministry of Education, College of Life Science, Nankai University, Tianjin, China Oct 2003 – Mar 2005 Research fellow at Division of Medical Devices, National Institute of Health Science (NIHS), Tokyo, Japan Oct 2001 – Sept 2003 Postdoctoral Fellowship (JSPS) at Division of Medical Devices, National Institute of Health Science (NIHS), Tokyo, Japan Aug 1990 – Aug 1994 Researcher Assistant at Tianjin Institute of hepato-biliary Disease, Tianjin 3rd Center Hospital, Tianjin, China

1. Cadehrin engineering matrix regulating extracellular microenvironment reconstruction

2. Chemical signals of the biomaterials inducing tissue regenerative and its molecular mechanisms

1. Ke Xu, Chuanshun Zhu, Jinghui Xie, Xiaoning Li, Yan Zhang*, Fanglian Yao, Zhongwei Gu, Jun Yang*. Enhanced vascularization of porous scaffolds through VEGF-Fc modification. J Mater. Chem B., 2018. (Accepted )

2. Ningning He, Xiaoniao Chen, Dan Wang, Ke Xu, Lingling Wu, Yuanyuan Liu, Hongyan Tao, Qinjun Zhao, Xiaocang Cao, Yuhao Li, Na Liu, Xin Qi, Zhongchao Han, Deling Kong, Jun Yang*, Zongjin Li*. VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway. Biomaterials, 2018, 158 (1), 34-43.

3. Ke Xu, Qizhi Shuai, Xiaoning Li, Yan Zhang, Chao Gao, Lei Cao, Feifei Hu, Toshihiro Akaike, Jianxi Wang, Zhaongwei Gu, Jun Yang*. Human VE-cadherin fusion protein as an artificial extracellular matrix enhancing the proliferation and differentiation functions of endothelial cell. Biomacromolecules, 2016,17 (3),756-766. (Editor’s choice, ASC 2016)

4. Yan Zhang, Hongli Mao, Chao Gao, Suhua Li, Qizhi Shuai, Jianbin Xu, Ke Xu, Lei Cao, Ren Lang*, Toshihiro Akaike, Jun Yang*. Enhanced biological functions of human mesenchymal stem cell aggregates incorporating E-cadherin-modified PLGA microparticles. Adv Healthc Mater, 2016, 15(5) :1949-1959.

5. Yan Zhang, Hongli Mao, Mengyuan Qian, Feifei Hu, Lei Cao, Ke Xu, Qizhi Shuai, Chao Gao, Ren Lang, Toshihiro Akaike, Jun Yang*. Surface modification with E-cadherin fusion protein for mesenchymal stem cell culture. J Mater. Chem B, 2016, 24(4):4237-4368. (Hot Paper, JMCB 2016)

6. 张妍许可高超杨军基于融合蛋白的生物材料及其在组织工程中的应用中国材料进展 2015, 34(3):204-215.

7. Jianbin Xu, Suhua Li, Feifei Hu, Chuanshun Zhu, Yan Zhang, Wei Zhao, Toshihiro Akaike and Jun Yang*. Artificial biomimicking matrix modifications of nanofibrous scaffolds by hE-cadherin-Fc fusion protein to promote human mesenchymal stem cells adhesion and proliferation. Journal of Nanoscience and Nanotechnology 2014,14(6):4007-13.

8. Jinbin Xu, Chuanshun Zhu, Yan Zhang, Nan Jiang, Suhua Li, Zhongyu Su, Toshihiro Akaike, Jun Yang*. hE-cadherin-Fc fusion protein coated surface enhances the adhesion and proliferation of human mesenchymal stem cells. Colloids and surfaces B: Biointerfaces 2013,109 :97-102.

9. Yi Shang, Miho Tamai, Ryusei Ishii, Noriyuki Nagaoka, Yasuhiro Yoshida, Masamichi Ogasawara, Jun Yang and Yohichi Tagawa. Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of hepatocytes and endothelial cells. Journal of Bioscience and Bioengineering 2014, 117:99-106.

10. Xu Jinbin, Zhang Yan, Li Suhua, Yao Fanglian, Akaike Toshihiro, YangJun*. Human E-cadherin-Fc fusion protein matrix improving the hepatic differentiation of human mesenchymal stem cells. Chinese Journal of Biomedicial Engineering 2013, 32(6):27-34.

11. Yu Meihua, Du Fengyi, Rao Xia, Yao Fanglian, Yang Jun*. Effects of artificial extracellular matrixes on the survival of vascular endothelial cells. Chemical Journal of Chinese Universities 2013,34(3):736-750.

12. Meihua Yu, Fengyi Du, Hirohiko Ise, Wei Zhao, Yan Zhang, Yaoting Yu, Fanglian Yao, Jun Yang*, Toshihiro Akaike. Preparation and characterization of a VEGF-Fc fusion protein matrix for enhancing HUVEC growth. Biotechnol. Lett. 2012,34:1765-1771.

13. Fengyi Du, Hao Wang, Deling Kong, Jun Yang* and Yuanyuan Zhang. Gradient functional nanofibrous scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials 2012,33:762-770.

(Every spring semester)An elective course for graduate students at College of Life Science – Micro / Nano Biomaterials, Nnakai University, China

(Every spring semester) An elective course for undergraduates at College of Life Science – Biomedical Materials, Nankai University, China