叶丽虹

南开大学生命科学学院教授、博士生导师和药物化学生物学国家重点实验室PI。任中国抗癌协会肿瘤标志物专业委员会常委、肿瘤转移专业委员会常委、中国生物化学与分子生物学学报编委、天津市侨联常委和南开大学工会教代会委员等。实验室主要从事肿瘤发生发展分子机制和抗肿瘤药物筛选等研究。在国际上首次报道了新的癌基因HBXIP可作为众多关键癌基因的转录辅激活因子在肿瘤的生长、转移、血管生成、免疫逃逸和糖脂代谢等过程中的重要作用及其分子调控机制。迄今共发表学术论文192篇，其中论著142篇（SCI 论著96篇）。近年（2010-2017年）以通讯作者在国际期刊上发表SCI 论著75 篇，其中发表在著名的国际期刊有2篇《Hepatology》、 3 篇《Cancer Research》、 2篇《Cell Research》、4 篇《Oncogene》、6篇《J.B.C》和4 篇《Carcinogenesis》等。回国后主持基金项目15项（973前期课题1项，国家自然科学基金9项，教育部和天津市基金5项），作为骨干参加973三项。在美国Nova科学出版社出版专著2部，参编学术专著3部；申请国家发明专利18项，获得国家发明专利6项。曾荣获中国抗癌协会科技奖二等奖1项，第六届中国侨界贡献（创新团队）奖1项，全国“新世纪巾帼发明家”优秀奖。

(1) 1993.3–1997.4, 群马大学, 药理学, 博士 (2) 1986.8–1989.7, 延边大学, 药理学, 硕士 (3) 1978.8–1983.7, 中国医科大学, 医疗, 学士

(1) 2000.12-至今, 南开大学, 生命科学学院分子生物学研究所, 教授 (2) 1998.4-2000.12, 日本理化学研究所, 理化学研究所, 研究员 (3) 1997.4-1998.2, 日本群马大学, 生化病理学系, 研究员 (4) 1992.10-1993.3, 日本群马大学, 生化病理学系, 访问学者 (5) 1989.8-1992.9, 大连医科大学, 药理教研室, 讲师

1.乳腺癌发生、发展和转移的分子机制研究

2.乳腺癌药物作用靶点的研究

3.抗肿瘤药物筛选及开发与应用

 

 

 

  主持的科研项目：

1)国家973计划项目：《恶性肿瘤癌前病变发生发展的分子机理研究》，课题骨干《癌前病变发生发展过程中上皮细胞与微环境的交互作用》 2015.1.1-2019.8.31，2015CB553905。

2)973计划前期：《新的转录因子类癌基因HBXIP在乳腺癌中的作用及其分子机制》2011.01-2013.12，项目编号2011CB512113。

3)国家973计划项目（骨干）：肿瘤和免疫细胞相互作用过程中蛋白质功能研究肿瘤和免疫细胞相互作用过程中蛋白质功能研究，2007.7-2011.8,项目编号：2007CB914800。参加973计划第四课题：新的抗肿瘤基因疫苗和蛋白疫苗的设计、作用及其免疫学分子机制2007.7-2011.8,项目编号：2007CB914804。

4)国家自然科学基金:《癌蛋白HBXIP对肝癌细胞糖异生的影响及其分子机制研究》，2017.1-2020.12，31670771。

5)国家自然科学基金:《癌蛋白HBXIP辅激活核受体LXR调节脂肪酸代谢对乳腺癌生长的作用及其分子机制研究》，2014.1-2017.12，81372186。

6)国家自然科学基金:《癌蛋白HBXIP调控Hippo-YAP通路促进乳腺癌增殖的作用及其分子机制研究》，2013.1-2013.12，项目编号：81272217。

7)国家自然科学基金:《乙肝病毒X蛋白相互作用蛋白对乳腺癌膜补体调节蛋白的调节作用及分子机制研究》2011.01-2013.12项目编号81071623(已结题)。

8)国家自然科学基金《乙肝病毒X蛋白结合蛋白（HBXIP）促进乳腺癌细胞增殖和迁移分子机制的研究》2008.01-2010.12,项目编号：30770826。

9)国家自然科学基金《花生四烯酸诱导肌球蛋白非磷酸化状态平滑肌细胞迁移的信号传导途径研究》2007.1-2009.12, 项目编号：30670423。

10)国家自然科学基金《肌球蛋白轻链激酶在肿瘤转移中的作用及其分子机理研究》2004-2006,项目编号：30370338。

11)国家自然科学基金《肌球蛋白轻链激酶对平滑肌细胞收缩的基因调控作用》2002-2004，项目编号:30170203。

12)国家自然科学基金《肌球蛋白轻链激酶基因调控在肿瘤细胞转移中的作用》2003-2004,项目编号：30270322。

13)天津市自然科学基金重点项目《HBXIP在YAP-TEAD转录复合物中的作用及其分子机制研究》2014-2017，项目编号：14JCZDJC32800。

14)天津市自然科学基金重点项目《花生四稀酸代谢促进乳腺癌增殖和迁移信号转导途径研究》2008-2010，（参加）项目编号：08JCZDJC20700。

15)天津市科技发展计划科技攻关项目：《建立和应用肿瘤转移相关基因生物芯片筛选抗肿瘤转移药物的研究》2004-2006,项目编号：043182911(已结题)。

16)天津市自然科学基金重点项目《肝癌转移相关基因的分离及其基因疫苗的研究》2001-2003，项目编号：013616211。

  

发表文章：

1.    Liu B, Wang T, Wang H, Zhang L, Xu F, Fang R, Li L, Cai X, Wu Y, Zhang WY*, Ye LH*. Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer. J Hematol Oncol. 2018 Feb 23;11(1):26.

2.    Wang T, Liu B, Guan Y, Gong M, Zhang WY, Pan J, Liu Y, Liang R, Yuan Y*, Ye L*. Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. Thorac Cancer. 2018 Mar;9(3):368-375. 3.Li H, Wang Z, Li Y, Fang R, Wang H, Shi H, Zhang X, Zhang W*, Ye L*. Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/NeuroD1 in animal pancreatic β cells. J Biol Chem. 2018 Feb 9;293(6):2053-2065.

4.    Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W*, Ye L*. HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. Cancer Lett. 2017 Nov 22;415:11-198.

5.    Feng GX, Li J, Yang Z, Zhang SQ, Liu YX, Zhang WY*, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA. Oncogene. 2017 Dec 14;36(50):6895-6905.

6.    Gao Y, Feng J, Yang G, Zhang S, Liu Y, Bu Y, Sun M, Zhao M, Chen F, Zhang W, Ye L*, Zhang X*. HBx-elevated MSL2 Modulates HBV cccDNA through Inducing Degradation of APOBEC3B to Enhance Hepatocarcinogenesis. Hepatology. 2017 Nov;66(5):1413-1429.

7.     Wang Y, Chen F, Zhao M, Yang Z, Li J, Zhang S, Zhang W, Ye L*, Zhang X*. The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186. J Biol Chem. 2017 Sep 15;292(37):15395-15407.

8.     Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L*, Zhang X*. The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. Sci Rep. 2017 May 18;7(1):2070.

9.    Zhang SQ, Yang Z, Cai XL, Zhao M, Sun MM, Li J, Feng GX, Feng JY, Ye LH, Niu JQ*, Zhang XD*. miR-511 promotes the proliferation of human hepatoma cells by targeting the 3'UTR of B cell translocation gene 1 (BTG1) mRNA. Acta Pharmacol Sin. 2017 Aug;38(8):1161-1170.

10.  Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X*. Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling. Biochem Biophys Res Commun. 2017 May 6;486(3):827-832.

11.  Zhang S, Gao S, Zhao M, Liu Y, Bu Y, Jiang Q, Zhao Q, Ye L*, Zhang X*. Anti-HBV Drugs Suppress the Growth of HBV-related Hepatoma Cells via Down-regulation of Hepatitis B Virus X Protein. Cancer Lett. 2017 Apr 28;392:94-104.

12.  Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, Zhang W*, Zhang X*, Ye L*. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Oncotarget. 2017 Apr 6;8(35):58338-58352.

13. Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y*, Zhang X*. MicroRNA-145 Modulates N6 methyladenosine Levels by Targeting the 3' Untranslated mRNA Region of the N6-methyladenosine binding YTH Domain Family 2 Protein. J Biol Chem. 2017 Mar 3;292(9):3614-3623.

14.  Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, Zhang W, Zhang X, Ye L*. HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochem Biophys Res Commun. 2017 Mar 11;484(3):565-571.

15.  Wang Y, Fang R, Cui M, Zhang W, Bai X, Wang H, Liu B, Zhang X*, Ye L*. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. Cancer Lett. 2017 Jan 28;385:234-242.

16.  Wang Y, Chen F, Zhao M, Yang Z, Zhang S, Ye L, Gao H*, Zhang X*. MiR-107 suppresses proliferation of hepatoma cells through targeting HMGA2 mRNA 3'UTR. Biochem Biophys Res Commun. 2016 Nov 18;480(3):455-460.

17.  Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, Chen F, Zhang S, Zhang X*, Ye L*. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett. 2016 Sep 5;382(2):147-156.

18.  Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F, Zhang X*, Ye L*. Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activatingthe LXRs/SREBP-1c/FAS Signaling Cascade. Cancer Res.2016 Aug 15;76(16):4696-707

19.  Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye L, Zhang W*, Zhang X*. Hepatitis B virus X protein up-regulates C4b-binding protein αthrough activating transcription factor Sp1in protection of hepatoma cells from complement attack. Oncotarget. 2016 May 10;7(19):28013-26.

20.  Feng G, Shi H, Li J, Yang Z, Fang R, Ye L, Zhang W*, Zhang X*. MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Biochem Biophys Res Commun. 2016 Apr 8;472(3):516-22.

21.  Gao YE, Wang Y, Chen FQ, Feng JY, Yang G, Feng GX, Yang Z, Ye LH*, Zhang XD*. Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN byendogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells. Acta Pharmacol Sin. 2016 Jul;37(7):898-907.

22.  Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X, Ye L*. The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Biochem Biophys Res Commun. 2016 Feb 26;471(1):89-94.

23.  Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z, Li J, Ye L*, Zhang X*. Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). Oncotarget. 2016 Jan 5;7(1):241-54.

24.  Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X*, Ye L*. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc. Cancer Res.2016 Jan 15;76(2):293-304.

25.  Li LL, Fang RP, Liu BW, Shi H, Wang Y, Zhang WY, Zhang XD*, Ye LH*. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene, 2016 Aug 4;35(31):4048-57.（

26.  Lu Z;Zhang W;Gao S;Jiang Q;Xiao Z;Ye L;Zhang X*. MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA. Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):8-13.

27.  Lu ZP, Xiao ZL, Yang Z, Li J, Feng GX, Chen FQ, Li YH, Feng JY, Gao YE, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factorAP2α and sphingosine kinase 1. Acta Pharmacol Sin. 2015 Oct;36(10):1228-36.

28.  Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X*, Ye L*. The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Growth of Breast Cancer. J Biol Chem. 2015 Sep 11;290(37):22649-61.

29.  Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X*, Ye L*. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015 Sep 29;6(29):27199-213.

30.  You J, Yang J, Fang R, Hu N, Zhang X, Zhang W*, Ye L*. Analysis of Phosphatidylcholines (PCs) and Lysophosphatidylcholines (LysoPCs) in Metastasis of Breast Cancer Cells.Progress in Biochemistry and Biophysics. 2015, 42(6): 563-573

31.  Zhang W, Lu Z, Gao Y, Ye L, Song T*, Zhang X*. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. Biochem Biophys Res Commun. 2015 May 8; 460(3):793-8.

32.  Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L*, Zhang X*. Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway. Cancer Res. 2015 Mar 1;75(5):846-57.

33.  Cui M, Zheng M, Sun B, Wang Y, Ye L, Zhang X*. A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis. Neoplasia. 2015 Jan;17(1):79-88

34.  Li L, Liu B, Zhang X*, Ye L*. The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation. Biochem Biophys Res Commun. 2015 Mar 13;458(3):720-5.

35.  Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang Z, Xiao Z, Lu Z, Ye L, Zhang X*. A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level. Biochem Biophys Res Commun. 2015 Apr 3;459(2):306-12.

36.  Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X*, Ye L*. The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Cancer Lett. (IF=5.0) 2014 Dec 28;355(2):288-96.

37.  Zhang XD, Wang Y, Ye LH. Hepatitis B virus X protein accelerates the development of hepatoma. Cancer Biol Med.2014 Sep;11(3):182-90.

38.  Zhang W, Lu Z，Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L and Zhang X*. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Molecular Cancer, 2014 May 28;13:128.

39.  Wang Y, Cui M, Cai X, Sun B, Liu F, Zhang X, Ye LH*. The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells. Cancer Lett, 2014 Oct 1;352(2):169-78. doi: 10.1016/j.canlet.2014.05.007. Epub 2014 May 29.

40.  Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH*. MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR. Acta Pharmacol Sin. 2014;35(9):1207-14. (IF=2.5) 2014 Sep;35(9):1207-14.

41.  Xu F, Zhu X, Han T, You X, Liu F, Ye L, Zhang X, Wang X, Yao Y. The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1. Int J Oncol. 2014 Jul;45(1):255-63.

42.  Cui M, Xiao Z, Sun B, Wang Y, Zheng M, Ye L, Zhang XD*. Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. Biochem Biophys Res Commun., 2014 Mar 14;445(3):651-5.

43.  Liu FB, You XN, Wang Y, Liu Q, Liu YX, Zhang SQ, Chen LY, Zhang XD*, Ye LH*. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis 2014 May;35(5):1144-53.

44.  Cui M, Wang Y, Sun B, Xiao Z, Ye LH, Zhang XD*. MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA. Biochem Biophys Res Commun., 2014 Jan ;444: 270-275.

45.  Liu FB, You XN, Chi YM, Wang T, Ye LH, Niu JQ, Zhang XD*. Hepatitis B virus X protein mutant HBxD127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Biochem Biophys Res Commun., 2014 Jan ;444: 128-134.

46.  You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, Du Y, Kong G, Wang T, Ye LH* and Zhang XD*. Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene, 2014 Jan ;33(4):449-60.

47.  Zhang T, Zhang J, Cui M,Liu F, You X, Du Y, Gao Y, Zhang S, Lu Z, Ye L and Zhang X*. Hepatitis B virus X protein inhibits tumor suppressor miR-205 via inducing hypermethylation of miR-205 promoter to enhance carcinogenesis. Neoplasia, 2013 Nov ；15(11): 1282-1291.

48.  Liu Q, Bai X, Li H, Zhang YY, Zhao Y, Zhang XD*, Ye LH*. The oncoprotein HBXIP up-regulates Lin28B via activating TFⅡD to promote proliferation of breast cancer cells. Int J Cancer.Sep 2013; 133(6):1310-22.

49.  Zhang YY, Zhao Y, Li H, Li YH, Cai XL, Shen Y, Shi H, Li LL, Liu Q, Zhang XD*, Ye LH*. The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells. J Biol Chem 2013 May; 288(26):18961-74.

50.  Zhang YY, Zhao Y, Li LL, Shen Y, Cai XL, Zhang XD*, Ye LH*. The Oncoprotein HBXIP up-regulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells. Biochem Biophys Res Commun., 2013 Mar;434: 305-310.

51.  Qiao L, Wu Q, Lu X, Zhou Y, Fernández-Alvarez A, Ye L, Zhang X, Han J, Casado M, Liu Q*. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter. Biochem Biophys Res Commun. 2013; 432(4):643-9.

52.  You XN, Liu FB, Zhang T, Li YH, Ye LH*, Zhang XD*. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis, 2013 Jul;34(7):1644-52.

53.  Xu FQ, You XN, Liu FB, Shen XH, Yao YQ, Ye LH*, Zhang XD*.The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. Cancer Letters, 2013 Jun; 333(1):124-32.

54.  Zhang S, Shan CL, Cui WJ, You XN, Du YM, Kong GY, Gao FB, Ye LH*, Zhang XD*. Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependentcytotoxicity by up-regulation of CD46. FEBS Letters 2013 Mar ;587 (6): 645-51.

55.  Yue L, Li LL, Liu FF, Hu N, Zhang WY, Bai X, Li HY, Fu L, Zhang XD*, Ye LH*. Oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis, 2013 Apr;;34(4):927-35.

56.  Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang H, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH,* Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters. 2012;586(19): 3215-21.

57.  Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*.HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem 2012; 287(36):30228-39.

58.  Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Ye LH* and Zhang XD*. Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology, 2012; 56(6): 2051-9.

59.  Du Y, Kong G, You X, Zhang S, Zhang T, Ye LH*, Zhang XD*. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem. 2012 ;287(31):26302-11.

60.  Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving 5-LOX, NF-κB, OPN and Capn4. PLoS One, 2012;7(2):e31458.

61.  Zhang W, Kong G, Zhang J, Wang T, Ye LH*, Zhang XD*. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e31450.

62.  Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD*, Ye LH*. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack. FEBS Letters,2012;586(6):766-71.

63.  Zhao Y, Wang W, Wang Q, Zhang XD*, Ye LH*. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells. Biochem Biophys Res Commun. 2012; 418(4):647-651.

64.  Wang Q，Zhang T，Ye LH，Wang WH，Zhang XD*. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiol. 2012; 36: 369-374.

65.  Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*.MicroRNA-520e Suppresses Growth of Hepatoma Cells by Targeting the NF-κB-inducing Kinase (NIK). Oncogene, 2012; 31(31):3607-20.

66.  Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin. 2011;32:1173-1180.

67.  Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang X*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS One. 2011;6(5):e19518.

68.  Shan C, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Zhang Z, Ye LH*, Zhang XD*. HBx activates CD59 through indirectly binding to the region of the CD59 promoter and down-regulating Let-7i. Carcinogenesis. 2011;32 (8):1190-7.

69.Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang XD*, Ye LH*. miR-520b regulates migration of breast cancer cells through targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem. 2011;286(15):13714-22.

70.  Hu N, Li Y, Zhao Y, Wang Q, You JC, Zhang XD*, Ye LH*.A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. Acta Pharmacol Sin. 2011; 2011;32:921-929.

71.  Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD*, Ye LH*. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′UTR of CD46. Cancer Biol Ther. 2010;10(3):232-241.

72.  Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD*, Ye LH*.Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin. 2010;31(6):725-732.

73.  Zhang X, Ye LH*, Zhang XD*. A mutant of hepatitis B virus X protein (HBx127) enhances cell migration via osteopontin (OPN) involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(5):593-600.

74.  Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD*. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010; 82: 920-928.

75.  Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010; 20(5):563-75.

76.  Wang Q, Zhang WY, Ye LH*, Zhang XD*. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(3): 367-374.

77.  Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye LH*, Zhang XD*. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase. Neoplasia. 2010;12(2):103-15.

78.  Zhou XL, Qin XR, Zhang XD*, Ye LH*. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin. 2010;31(2):202-10.

79.  Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH*, Zhang XD*. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV. J Biomed Biotechnol. 2009;2009:289068.

80.  Zhang WY, Cai N, Ye LH*, Zhang XD*. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sinica. 2009; 30(8):1153-61.

81.  Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH*, Zhang XD*. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sin,2009; 30(4):424-434.

82.  You J, Mi D, Zhou X, Qiao L, Xu S, Zhang XD*, Ye LH*. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation and migration. Endocrinology，2009;150(4):1607-17.

83.  Zhou X, Liu Y, You J, Zhang XD*, Ye LH*. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Letters 2008; 270:312-327.

84.  Qiao L, Xu ZL, Zhao TJ, Ye LH*, Zhang XD*. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters 2008;269(1):67-77.

85.Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye LH*, Zhang XD*. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res 2008;18:500-507.

86.  Ye LH, Dong N，Wang Q，Xu ZL，Cai N，Wang HH，Zhang XD*. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology, 2008;51:50-58.

87.  Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye LH*, Zhang XD*. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and its effect on liver cell proliferation. Acta Pharmacologica Sin,2008;29(4):473-80.

88.  Qiao L, Zhao T, Wang F, Shan C, Ye LH*, Zhang XD*. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. Acta Pharmacologica Sin, 2008;29(3):333-340.

89.  Wang F, Sha L, Ye LH*, Zhang XD*. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. Acta Pharmacologica Sin, 2008; 29(1)-83-89.

90.  Qin X, Zhang H, Zhou X, Zhang H, Zhang XD*, Ye LH*. Proliferation and migration mediated by Dkk-1/Wnt/-catenin cascade in a model of hepatocellular carcinoma (HCC) cells. Translational Res 2007;150(5): 281-294.

91.  Wang F, Sha L, Zhang W, Wu L, Zhang X*, Ye LH*. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. Acta Pharmacologica Sin, 2007;28(3) : 431-438.

92.   Zhang XD*, Zhang W, Ye LH. Pathogenesis of hepatitis B virus infection. Future Virol 2006;1(5):637-647.

93.   Zhang XD*, Zhang H, Ye LH*. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab. Clin. Med. 2006;.147(2):58-66.

94.  Zhang XD*, Dong N, Zhang H, You J, Wang H and Ye LH*. Effects of hepatitis B virus X protein on hTERT expression and activity in hepatoma cells. J Lab. Clin. Med. 2005; 145(2):98-104.

95.  Zhang XD*, Dong N, Yin L, Cai N, Ma H, Zhang H, You J, Wang H, He R and Ye LH*. Hepatitis B virus X protein up-regulates survivin expression in hepatoma tissues. J Med. Virol 2005; 77:374-381.

  

 

  

  

   

  

1.中国抗癌协会肿瘤标志物专业委员会常委

2.肿瘤转移专业委员会常委

3.中国生物化学与分子生物学学报编委

4.中国生物化学与分子生物技术专业委员会委员

5.天津市侨联常委

6.南开大学工会教代会委员

7.校工会女工委员会委员

8.Oncogene、Cell Proliferation、Acta Pharmacol Sin.等学术期刊审稿人

 

1.讲授本科生《分子生物学》

2.讲授硕士研究生《高级生化》

3.讲授博士研究生《生物化学与分子生物学研究前沿专题讲座》  

全国“新世纪巾帼发明家”优秀奖

天津市巾帼发明家创新奖

天津市知识产权系统“十大女杰”

天津市2007年度专利优秀奖

中国抗癌协会科技奖二等奖

第六届中国侨界贡献（创新团队）奖