Yelihong

Research in Ye’s laboratory has focused on the mechanism of the development of tumor and screening new drugs of anti-cancer. Currently there are some projects on going in her lab. One project deals with the role of new oncoprotein HBXIP (Hepatitis B virus X-interacting protein) in the development of breast cancer. Second one concerns the effect of HBXIP on abnormal glucose and lipid metabolism in cancer. Third one is committed to the research and development of new drugs of anti-cancer. As a corresponding author since 2010, she has published over 75 SCI original research articles and review articles in Hepatology, Cancer Research, Oncogene, J.B.C, Neoplasia, Cell Research, Carcinogenesis, Cancer letters and Endocrinology, and others. She wrote two books on Hepatitis B Virus Research published in Nova Publisher of America. She obtained two grants of two 973 programs and nine grants of National Natural Science Foundation in China.

Apr 1998-Dec 2000：Postdoctoral fellow, Gunma University, Japan, supported by Japan Society for the Promotion of Science (JSPS) Mar 1993-Apr 1997：Ph.D., Gunma University, Japan Aug 1986-Jul 1989： MSc, Yanbian University, China Aug 1978-Jul 1983： M.D. China Medical University, China

Dec 2000-Now: Professor, Director, Department of Biochemistry, Institute for Molecular Biology, College of Life Sciences, Nankai University, China Apr 1998-Dec 2000: Professor, RIkagaku KENkyusho/Institute of Physical and Chemical Research, Japan Apr 1997-Feb 1998: Professor, Gunma University, Japan Qct 1992-Mar 1993: Visiting scholar, Gunma University, Japan Aug 1989-Sep 1992: Assistant professor, Dalian Medical University, China

1. Research on Molecular Mechanism of Occurrence, Development and Metastasis of Breast Cancer

2. Research on Anti-breast cancer Drug Targets 

3.New Anti-cancer Drug Research & Development  

 

 Selected Publications:

1.    Liu B, Wang T, Wang H, Zhang L, Xu F, Fang R, Li L, Cai X, Wu Y, Zhang WY*, Ye LH*. Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer. J Hematol Oncol. 2018 Feb 23;11(1):26.

2.    Wang T, Liu B, Guan Y, Gong M, Zhang WY, Pan J, Liu Y, Liang R, Yuan Y*, Ye L*. Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. Thorac Cancer. 2018 Mar;9(3):368-375. 3.Li H, Wang Z, Li Y, Fang R, Wang H, Shi H, Zhang X, Zhang W*, Ye L*. Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/NeuroD1 in animal pancreatic β cells. J Biol Chem. 2018 Feb 9;293(6):2053-2065.

4.    Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W*, Ye L*. HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. Cancer Lett. 2017 Nov 22;415:11-19. 8

5.    Feng GX, Li J, Yang Z, Zhang SQ, Liu YX, Zhang WY*, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA. Oncogene. 2017 Dec 14;36(50):6895-6905

6.    Gao Y, Feng J, Yang G, Zhang S, Liu Y, Bu Y, Sun M, Zhao M, Chen F, Zhang W, Ye L*, Zhang X*. HBx-elevated MSL2 Modulates HBV cccDNA through Inducing Degradation of APOBEC3B to Enhance Hepatocarcinogenesis. Hepatology. 2017 Nov;66(5):1413-1429.

7.    Wang Y, Chen F, Zhao M, Yang Z, Li J, Zhang S, Zhang W, Ye L*, Zhang X*. The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA- 186. J Biol Chem. 2017 Sep 15;292(37):15395-15407.

8.    Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L*, Zhang X*. The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. Sci Rep. 2017 May 18;7(1):2070.

9.    Zhang SQ, Yang Z, Cai XL, Zhao M, Sun MM, Li J, Feng GX, Feng JY, Ye LH, Niu JQ*, Zhang XD*. miR-511 promotes the proliferation of human hepatoma cells by targeting the 3'UTR of B cell translocation gene 1 (BTG1) mRNA. Acta Pharmacol Sin. 2017 Aug;38(8):1161-1170.

10.  Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X*. Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling. Biochem Biophys Res Commun. 2017 May 6;486(3):827-832.

11.   Zhang S, Gao S, Zhao M, Liu Y, Bu Y, Jiang Q, Zhao Q, Ye L*, Zhang X*. Anti-HBV Drugs Suppress the Growth of HBV-related Hepatoma Cells via Down-regulation of Hepatitis B Virus X Protein. Cancer Lett. 2017 Apr 28;392:94-104.

12.   Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, Zhang W*, Zhang X*, Ye L*. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Oncotarget. 2017 Apr 6;8(35):58338-58352.

13.   Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y*, Zhang X*. MicroRNA-145 Modulates N6 methyladenosine Levels by Targeting the 3' Untranslated mRNA Region of the N6-methyladenosine binding YTH Domain Family 2 Protein. J Biol Chem. 2017 Mar 3;292(9):3614-3623.

14.   Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, Zhang W, Zhang X, Ye L*. HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer. Biochem Biophys Res Commun. 2017 Mar 11;484(3):565-571.

15.   Wang Y, Fang R, Cui M, Zhang W, Bai X, Wang H, Liu B, Zhang X*, Ye L*. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. Cancer Lett. 2017 Jan 28;385:234-242.

16.  Wang Y, Chen F, Zhao M, Yang Z, Zhang S, Ye L, Gao H*, Zhang X*. MiR-107 suppresses proliferation of hepatoma cells through targeting HMGA2 mRNA 3'UTR. Biochem Biophys Res Commun. 2016 Nov 18;480(3):455-460.

17.  Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, Chen F, Zhang S, Zhang X*, Ye L*. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett. 2016 Sep 5;382(2):147-156.

18.  Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F, Zhang X*, Ye L*. Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activatingthe LXRs/SREBP-1c/FAS Signaling Cascade. Cancer Res.2016 Aug 15;76(16):4696-707

19.  Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye L, Zhang W*, Zhang X*. Hepatitis B virus X protein up-regulates C4b-binding protein αthrough activating transcription factor Sp1in protection of hepatoma cells from complement attack. Oncotarget. 2016 May 10;7(19):28013-26.

20.  Feng G, Shi H, Li J, Yang Z, Fang R, Ye L, Zhang W*, Zhang X*. MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Biochem Biophys Res Commun. 2016 Apr 8;472(3):516-22.

21.  Gao YE, Wang Y, Chen FQ, Feng JY, Yang G, Feng GX, Yang Z, Ye LH*, Zhang XD*. Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN byendogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells. Acta Pharmacol Sin. 2016 Jul;37(7):898-907.

22.  Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X, Ye L*. The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Biochem Biophys Res Commun. 2016 Feb 26;471(1):89-94.

23.   Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z, Li J, Ye L*, Zhang X*. Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). Oncotarget. 2016 Jan 5;7(1):241-54.

24.   Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X*, Ye L*. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc. Cancer Res.2016 Jan 15;76(2):293-304.

25.   Li LL, Fang RP, Liu BW, Shi H, Wang Y, Zhang WY, Zhang XD*, Ye LH*. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene, 2016 Aug 4;35(31):4048-57.（

26.   Lu Z;Zhang W;Gao S;Jiang Q;Xiao Z;Ye L;Zhang X*. MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA. Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):8-13.

27.   Lu ZP, Xiao ZL, Yang Z, Li J, Feng GX, Chen FQ, Li YH, Feng JY, Gao YE, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factorAP2α and sphingosine kinase 1. Acta Pharmacol Sin. 2015 Oct;36(10):1228-36.

28.  Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X*, Ye L*. The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Growth of Breast Cancer. J Biol Chem. 2015 Sep 11;290(37):22649-61.

29.   Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X*, Ye L*. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015 Sep 29;6(29):27199-213.

30.  You J, Yang J, Fang R, Hu N, Zhang X, Zhang W*, Ye L*. Analysis of Phosphatidylcholines (PCs) and Lysophosphatidylcholines (LysoPCs) in Metastasis of Breast Cancer Cells.Progress in Biochemistry and Biophysics. 2015, 42(6): 563-573

31.  Zhang W, Lu Z, Gao Y, Ye L, Song T*, Zhang X*. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. Biochem Biophys Res Commun. 2015 May 8; 460(3):793-8.

32.  Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L*, Zhang X*. Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway. Cancer Res. 2015 Mar 1;75(5):846-57.

33.  Cui M, Zheng M, Sun B, Wang Y, Ye L, Zhang X*. A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis. Neoplasia. 2015 Jan;17(1):79-88

34.  Li L, Liu B, Zhang X*, Ye L*. The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation. Biochem Biophys Res Commun. 2015 Mar 13;458(3):720-5.

35.  Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang Z, Xiao Z, Lu Z, Ye L, Zhang X*. A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level. Biochem Biophys Res Commun. 2015 Apr 3;459(2):306-12.

36.  Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X*, Ye L*. The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Cancer Lett. (IF=5.0) 2014 Dec 28;355(2):288-96.

37.  Zhang XD, Wang Y, Ye LH. Hepatitis B virus X protein accelerates the development of hepatoma. Cancer Biol Med.2014 Sep;11(3):182-90.

38.  Zhang W, Lu Z，Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L and Zhang X*. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Molecular Cancer, 2014 May 28;13:128.

39.  Wang Y, Cui M, Cai X, Sun B, Liu F, Zhang X, Ye LH*. The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells. Cancer Lett, 2014 Oct 1;352(2):169-78. doi: 10.1016/j.canlet.2014.05.007. Epub 2014 May 29.

40.  Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH*. MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR. Acta Pharmacol Sin. 2014;35(9):1207-14. (IF=2.5) 2014 Sep;35(9):1207-14.

41.  Xu F, Zhu X, Han T, You X, Liu F, Ye L, Zhang X, Wang X, Yao Y. The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1. Int J Oncol. 2014 Jul;45(1):255-63.

42.  Cui M, Xiao Z, Sun B, Wang Y, Zheng M, Ye L, Zhang XD*. Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. Biochem Biophys Res Commun., 2014 Mar 14;445(3):651-5.

43.  Liu FB, You XN, Wang Y, Liu Q, Liu YX, Zhang SQ, Chen LY, Zhang XD*, Ye LH*. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis 2014 May;35(5):1144-53.

44.  Cui M, Wang Y, Sun B, Xiao Z, Ye LH, Zhang XD*. MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA. Biochem Biophys Res Commun., 2014 Jan ;444: 270-275.

45.  Liu FB, You XN, Chi YM, Wang T, Ye LH, Niu JQ, Zhang XD*. Hepatitis B virus X protein mutant HBxD127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Biochem Biophys Res Commun., 2014 Jan ;444: 128-134.

46.  You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, Du Y, Kong G, Wang T, Ye LH* and Zhang XD*. Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells. Oncogene, 2014 Jan ;33(4):449-60.

47.  Zhang T, Zhang J, Cui M,Liu F, You X, Du Y, Gao Y, Zhang S, Lu Z, Ye L and Zhang X*. Hepatitis B virus X protein inhibits tumor suppressor miR-205 via inducing hypermethylation of miR-205 promoter to enhance carcinogenesis. Neoplasia, 2013 Nov ；15(11): 1282-1291.

48.  Liu Q, Bai X, Li H, Zhang YY, Zhao Y, Zhang XD*, Ye LH*. The oncoprotein HBXIP up-regulates Lin28B via activating TFⅡD to promote proliferation of breast cancer cells. Int J Cancer.Sep 2013; 133(6):1310-22.

49.  Zhang YY, Zhao Y, Li H, Li YH, Cai XL, Shen Y, Shi H, Li LL, Liu Q, Zhang XD*, Ye LH*. The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells. J Biol Chem 2013 May; 288(26):18961-74.

50.  Zhang YY, Zhao Y, Li LL, Shen Y, Cai XL, Zhang XD*, Ye LH*. The Oncoprotein HBXIP up-regulates PDGFB via activating transcription factor Sp1 to promote proliferation of breast cancer cells. Biochem Biophys Res Commun., 2013 Mar;434: 305-310.

51.  Qiao L, Wu Q, Lu X, Zhou Y, Fernández-Alvarez A, Ye L, Zhang X, Han J, Casado M, Liu Q*. SREBP-1a activation by HBx and the effect on hepatitis B virus enhancer II/core promoter. Biochem Biophys Res Commun. 2013; 432(4):643-9.

52.  You XN, Liu FB, Zhang T, Li YH, Ye LH*, Zhang XD*. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis, 2013 Jul;34(7):1644-52.

53.  Xu FQ, You XN, Liu FB, Shen XH, Yao YQ, Ye LH*, Zhang XD*.The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. Cancer Letters, 2013 Jun; 333(1):124-32.

54.  Zhang S, Shan CL, Cui WJ, You XN, Du YM, Kong GY, Gao FB, Ye LH*, Zhang XD*. Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependentcytotoxicity by up-regulation of CD46. FEBS Letters 2013 Mar ;587 (6): 645-51.

55.  Yue L, Li LL, Liu FF, Hu N, Zhang WY, Bai X, Li HY, Fu L, Zhang XD*, Ye LH*. Oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis, 2013 Apr;;34(4):927-35.

56.  Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang H, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH,* Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters. 2012;586(19): 3215-21.

57.  Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*.HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem 2012; 287(36):30228-39.

58.  Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Ye LH* and Zhang XD*. Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology, 2012; 56(6): 2051-9.

59.  Du Y, Kong G, You X, Zhang S, Zhang T, Ye LH*, Zhang XD*. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem. 2012 ;287(31):26302-11.

60.  Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving 5-LOX, NF-κB, OPN and Capn4. PLoS One, 2012;7(2):e31458.

61.  Zhang W, Kong G, Zhang J, Wang T, Ye LH*, Zhang XD*. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e31450.

62.  Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD*, Ye LH*. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack. FEBS Letters,2012;586(6):766-71.

63.  Zhao Y, Wang W, Wang Q, Zhang XD*, Ye LH*. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells. Biochem Biophys Res Commun. 2012; 418(4):647-651.

64.  Wang Q，Zhang T，Ye LH，Wang WH，Zhang XD*. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiol. 2012; 36: 369-374.

65. Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*.MicroRNA-520e Suppresses Growth of Hepatoma Cells by Targeting the NF-κB-inducing Kinase (NIK). Oncogene, 2012; 31(31):3607-20.

66.  Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin. 2011;32:1173-1180.

67.  Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang X*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS One. 2011;6(5):e19518.

68.  Shan C, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Zhang Z, Ye LH*, Zhang XD*. HBx activates CD59 through indirectly binding to the region of the CD59 promoter and down-regulating Let-7i. Carcinogenesis. 2011;32 (8):1190-7.

69.  Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang XD*, Ye LH*. miR-520b regulates migration of breast cancer cells through targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem. 2011;286(15):13714-22.

70.  Hu N, Li Y, Zhao Y, Wang Q, You JC, Zhang XD*, Ye LH*.A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. Acta Pharmacol Sin. 2011; 2011;32:921-929.

71.  Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD*, Ye LH*. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′UTR of CD46. Cancer Biol Ther. 2010;10(3):232-241.

72.  Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD*, Ye LH*.Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin. 2010;31(6):725-732.

73.  Zhang X, Ye LH*, Zhang XD*. A mutant of hepatitis B virus X protein (HBx127) enhances cell migration via osteopontin (OPN) involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(5):593-600.

74.  Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD*. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010; 82: 920-928.

75.  Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010; 20(5):563-75.

76.  Wang Q, Zhang WY, Ye LH*, Zhang XD*. A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin. 2010; 31(3): 367-374.

77.  Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye LH*, Zhang XD*. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase. Neoplasia. 2010;12(2):103-15.

78.  Zhou XL, Qin XR, Zhang XD*, Ye LH*. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin. 2010;31(2):202-10.

79.  Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH*, Zhang XD*. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV. J Biomed Biotechnol. 2009;2009:289068.

80.  Zhang WY, Cai N, Ye LH*, Zhang XD*. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sinica. 2009; 30(8):1153-61.

81.  Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH*, Zhang XD*. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sin,2009; 30(4):424-434.

82.  You J, Mi D, Zhou X, Qiao L, Xu S, Zhang XD*, Ye LH*. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation and migration. Endocrinology，2009;150(4):1607-17.

83.  Zhou X, Liu Y, You J, Zhang XD*, Ye LH*. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Letters 2008; 270:312-327.

84.  Qiao L, Xu ZL, Zhao TJ, Ye LH*, Zhang XD*. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters 2008;269(1):67-77.

85.  Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye LH*, Zhang XD*. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res 2008;18:500-507.

86.  Ye LH, Dong N，Wang Q，Xu ZL，Cai N，Wang HH，Zhang XD*. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology, 2008;51:50-58.

87.  Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye LH*, Zhang XD*. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and its effect on liver cell proliferation. Acta Pharmacologica Sin,2008;29(4):473-80.

88.  Qiao L, Zhao T, Wang F, Shan C, Ye LH*, Zhang XD*. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. Acta Pharmacologica Sin, 2008;29(3):333-340.

89.  Wang F, Sha L, Ye LH*, Zhang XD*. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. Acta Pharmacologica Sin, 2008; 29(1)-83-89.

90.  Qin X, Zhang H, Zhou X, Zhang H, Zhang XD*, Ye LH*. Proliferation and migration mediated by Dkk-1/Wnt/-catenin cascade in a model of hepatocellular carcinoma (HCC) cells. Translational Res 2007;150(5): 281-294.

91.  Wang F, Sha L, Zhang W, Wu L, Zhang X*, Ye LH*. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. Acta Pharmacologica Sin, 2007;28(3) : 431-438.

92.  Zhang XD*, Zhang W, Ye LH. Pathogenesis of hepatitis B virus infection. Future Virol 2006;1(5):637-647.

93.  Zhang XD*, Zhang H, Ye LH*. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab. Clin. Med. 2006;.147(2):58-66.

94.  Zhang XD*, Dong N, Zhang H, You J, Wang H and Ye LH*. Effects of hepatitis B virus X protein on hTERT expression and activity in hepatoma cells. J Lab. Clin. Med. 2005; 145(2):98-104.

95.  Zhang XD*, Dong N, Yin L, Cai N, Ma H, Zhang H, You J, Wang H, He R and Ye LH*. Hepatitis B virus X protein up-regulates survivin expression in hepatoma tissues. J Med. Virol 2005; 77:374-381.

  

Undergraduate course < Molecular Biology>

postgraduate course <Advanced Biochemistry>

doctoral course <Lectures on Frontiers of the Discipline of Biochemistry and Molecular Biology>