Yu Qilin

I focus on excavation and prevention of novel pathogens, together with regulation of microbiome structures and functions by synhetic biology and chemical engineering strategies. I have presided 8 national and provincial projects, published more than 40 papers in the areas of environmental microbiology, medical microbiology, and material science, and been authorized with 4 national invention patents.

2010.09-2013.06: Department of Microbiology, College of Life Sciences, Nankai University,Ph.D.

2021.12-present: Department of Microbiology, College of Life Sciences, Nankai University, Professor 2019.07-2020.08: Department of Chemistry and Biochemistry, UCLA, Visiting Scholar 2016.12-2021.12: Department of Microbiology, College of Life Sciences, Nankai University, Associated Professor

Our team is devoted to interdisciplinary researches in environmental microbiology, synthetic biology, together with environmental and chemical engineering. Main research interests:

(1) Regulation of environmental microbiome structures and functions by synthetic biology strategies. By rational construction of artificially synthetic microbes and engineered proteins, the structures and functions of plant rhizosphere microbiomes were regulated to enhance the stress-tolerating capacity and the bioremediation efficiency of remediation plants, or to promote the rhizosphere nitrogen-fixing capacity of economic plants.

(2) Exploration and control of pathogens and drug-resistant genes by chemical engineering strategies. By mesoporous structure engineering and supramolecular assembling, a series of functional nanomaterials, e.g., magnetic assemblies, metal organic frameworks, and vacancy-engineered microspheres,  were designed for specific adsorption of pathogens and drug-resistant genes to explore novel pathogens or drug-resistant genes, and to remove these hazardous elements from the ecosystems.

2022

1. Yan Zhao, Shuo Liu, Zhishang Shi, Hangqi Zhu, Mingchun Li, Qilin Yu*. (2022). Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection. Nano Research, DOI: 10.1007/s12274-022-4211-z. 

2. Hongda Yin, Yuqiao Chen, Yuming Feng, Lian Feng, Qilin Yu*. (2022). Synthetic physical contact-remodeled rhizosphere microbiome for enhanced phytoremediation. Journal of Hazardous Materials, 433, 128828. 10.1016/j.jhazmat.2022.128828.

3. JongGuk Kim, Jingyu Sun, Yan Zhao, Jinghong Wen, Bo Zhou, Ze Zhang, Shudi Mo, Jianling Wang, Huajie Liu*, Guichang Wang*, Qilin Yu*, Mingyang Liu*. (2022). Electronic structure modulation of Ag2S by vacancy engineering for efficient bacterial infection. Small, 18, 2107807. DOI: 10.1002/smll.202107807.

4. Ze Zhang, Jingyu Sun, Shudi Mo, Jongguk Kim, Donggnag Guo*, Jing Ju*, Qilin Yu*, Mingyang Liu*. (2022). Constructing a highly efficient CuS/Cu9S5 heterojunction with boosted interfacial charge transfer for near-infrared photocatalytic disinfection. Chemical Engineering Journal, 431, 134287.

5. Shudi Mo#, Yan Zhao#, Jinghong Wen, Jingyu Sun, Ze Zhang, Qilin Yu*, Guichang Wang*, Xue Chen*, Mingyang Liu*. (2022). Efficient photothermal and photodynamic synergistic antibacterial therapy of Cu7S4 nanosheets regulated by facet engineering. Journal of Hazardous Materials, 432, 128662.

6. Xian-Yin Dai, Bing Zhang, Qilin Yu*, Yu Liu*. (2022). In Situ Coassembly Induced Mitochondrial Aggregation Activated Drug-Resistant Tumor Treatment. Journal of Medicinal Chemistry. 65 (10), 7363-7370. https://doi.org/10.1021/acs.jmedchem.2c00372.

  

2021

1. Mingyang Liu, Hangqi Zhu, Nali Zhu, Qilin Yu*. (2021). Vacancy engineering of BiOCl microspheres for efficient removal of multidrug-resistant bacteria and antibiotic-resistant genes in wastewater. Chemical Engineering Journal, 426, 130710. (2021-06-03)

2. Fang-Chu Lin#, Qilin Yu#, Jeffrey I. Zink*. Self-Contained Nanocapsules Carrying Anticancer Peptides for Magnetically Activated and Enzyme-Cleaved Drug Delivery. ACS Applied Nano Materials , 2021, 4, 10, 10771–10783. (2021-09-23)

 

2020

1. Qilin Yu, Tian Deng, Fang-Chu Lin, Bing Zhang, Jeffrey I. Zink*. (2020). Supramolecular assemblies of heterogeneous mesoporous silica nanoparticles to co-deliver antimicrobial peptides and antibiotics for synergistic eradication of pathogenic biofilms. ACS Nano, 14(5), 5926-5937. (2020-04-20)

2. Gui-Yuan Wu, Xueliang Shi*, Hoa Phan, Hang Qu, Yi-Xiong Hu, Guang-Qiang Yin, Xiao-Li Zhao, Xiaopeng Li, Lin Xu, Qilin Yu*, Hai-Bo Yang*. (2020). Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity. Nature Communications, 2020, 11, 3178. DOI: 10.1038/s41467-020-16940-z. (2020-05-21)

3. Mingyang Liu, Yang Lu, Qilin Yu*, Shu-Hong Yu*. (2020). In situ assembly of magnetic nanocrystals/graphene oxide nanosheets on tumor cells enables efficient cancer therapy. Nano Research, 13(4), 1133–1140. (2020-03-16)

4. Nali Zhu, Bing Zhang, Qilin Yu*. (2020). Genetic engineering-facilitated coassembly of synthetic bacterial cells and magnetic nanoparticles for efficient heavy metal removal. ACS Applied Materials & Interfaces, 12(20), 22948-22957. (2020-04-27)

5. Qilin Yu, Bing Zhang, Ying-Ming Zhang, Yao-Hua Liu, Yu Liu*. (2020). Actin Cytoskeleton-Disrupting and magnetic field-responsive multivalent supramolecular assemblies for efficient cancer therapy. ACS Applied Materials & Interfaces, 12(12), 13709-13717. (2020-03-02)

6. Qilin Yu, Guizhu Wu, Tong Zhang, Xudong Zhao, Zhen Zhou, Lu Liu*, Wei Chen*, Pedro Alvarez*. (2020). Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides. Chemical Communications. 56, 7613-7616. DOI: 10.1039/D0CC02930K. (2020-06-01)

7. Bing Zhang, Liping Peng, Nali Zhu, Qilin Yu*, Mingchun Li*. (2020). Novel role of the phosphatidylinositol phosphatase Sac1 in membrane homeostasis and polarized growth in Candida albicans. International Journal of Medical Microbiology, 310(4), 151418. (2020-03-24)

8. Jinpeng Liu, Nali Zhu, Youjun Zhang, Tongtong Ren, Chaofeng Shao, Rongguang Shi, Xiaohua Li, Meiting Ju, Ting Ma*, Qilin Yu*. Transcription profiling-guided remodeling of sulfur metabolism in synthetic bacteria for efficiently capturing heavy metals. Journal of Hazardous Materials, 2020, 403, 123638. (2020.08.09)

9. Liping Peng, Henan Wei, Lei Tian, Jiachun Xu, Mingchun Li*, Qilin Yu*. (2021). Phospholipid/protein co-mediated assembly of Cu2O nanoparticles for specific inhibition of growth and biofilm formation of pathogenic fungi.Science China Materials, 64, 759–768. https://doi.org/10.1007/s40843-020-1457-1. (2020-10-16)

10. Hangqi Zhu, Bing Zhang, Nali Zhu, Mingchun Li*, Qilin Yu*. (2021). Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions. Chinese Chemical Letters, 32(3), 1220-1223.

11. Mingyang Liu, Qilin Yu*, Wei Chen, Xiangsheng Liu *, Pedro J. J. Alvarez. (2020). Engineering of CoSe2 Nanosheets via Vacancy Manipulation for Efficient Cancer Therapy. ACS Applied Bio Materials, 3(11), 7800-7809.

12. Jingxuan Hu, Zijing Liu, Qilin Yu*, Ting Ma*. Preparation of reactive oxygen species-responsive antibacterial hydrogels for efficient anti-infection therapy. Materials Letters, 263, 15 March 2020, 127254. (2020-03-01)

 

2019

1. Yang Yang, Pengkun Wei, Zewei Hao, Qilin Yu*, Huajie Liu*, Lu Liu*. (2019). Adjustable ternary FeCoNi nanohybrids for enhanced oxygen evolution reaction. Chemistry–A European Journal, 25(67), 15361-15366. (2019-09-20)

2. Guizhu Wu, Ze Zhang, Xue Chen, Qilin Yu*, Xiaoyong Ma*, Lu Liu*. (2019). Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux. Ecotoxicology and Environmental Safety, 167, 301-308. (2018-10-18)

3. Jinpeng Liu, Nali Zhu, Haiming Xu, Jinwu Bai, Chaofeng Shao, Meiting Ju, Qilin Yu*, and Lu Liu*. (2019). Construction of recycling photocatalytic gels for the disinfection of pathogens and degradation of organic pollutants. ChemistryOPEN, 8(10), 1309-1315. (2019-10-23)

4. Qilin Yu, Tianyu Ma, Congcong Ma, Biao Zhang, Mingchun Li *. (2019). Multifunction of the ER P-Type Calcium Pump Spf1 During Hyphal Development in Candida albicans. Mycopathologia, 184(5), 573-583. (2019-08-31)

5. Tongtong Ren, Yufan Wang, Qilin Yu*, Mingchun Li*.Synthesis of antimicrobial peptide-grafted graphene oxide nanosheets with high antimicrobial efficacy. Materials Letters, 235, 42-45. (2019-01-01 )

6. Nali Zhu, Li Yang, Liping Peng, Hangqi Zhu, Qilin Yu*, Mingchun Li*. (2019). The endoplasmic reticulum-plasma membrane tethering protein Ist2 regulates endoplasmic reticulum stress response in Candida albicans. SCIENTIA SINICA Vitae, 49(9), 1165-1172. (2019-09-09)

 

2018

1. Qilin Yu, Ying-Ming Zhang, Yao-Hua Liu, Xun Xu, Yu Liu*. (2018). Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis. Science Advances, 4(9), eaat2297. (2018-09-19)

2. Qilin Yu,Ying-Ming Zhang, Yao-Hua Liu, Yu Liu. (2018). Magnetic supramolecular nanofibers of gold nanorods for photothermal therapy. Advanced Therapeutics, 2(4), 1800137. (2018-11-29)

3. Da Huo, Bing Zhang, Qi Peng, Hongyue Li, Hui Wang, Qilin Yu*, Mingchun Li^*. (2018). Graphene oxide severely inhibits DNase activity. Journal of Applied Toxicology, 38(12), 1538-1544.

4. Qi Peng, Da Huo, Hongyue Li, Bing Zhang, Yang Li, Anping Liang, Qilin Yu*, Mingchun Li*. (2018). ROS-independent toxicity of Fe3O4 nanoparticles to yeast cells: Involvement of mitochondrial dysfunction. Chemico-Biological Interactions, 287, 20-26.

5. Honggang Wang, Tongtong Ren, Nali Zhu, Qilin Yu*, Mingchun Li. (2018). Co₃O₄ nanoparticles at sublethal concentrations inhibit cell growth by impairing mitochondrial function. Biochemical and Biophysical Research Communications, 505(3), 775-780.

 

2017

1. Qilin Yu*, Bing Zhang, Jianrong Li, Mingchun Li*. Design of peptide-grafted graphene oxide targeting the actin cytoskeleton for efficient cancer therapy. Chemical Communications, 2017, 53, 11433-11436. (2017-09-16)

2. Qilin Yu, Bing Zhang, Jianrong Li, Tingting Du, Xiao Yi, Mingchun Li*, Wei Chen*, Pedro J. J. Alvarez. Graphene oxide significantly inhibits cell growth at sublethal concentrations by causing extracellular iron deficiency. Nanotoxicology, 2017, 11(9-10), 1102-1114. (2017-11-09)

3. Qilin Yu, Honggang Wang, Qi Peng, Ye Li, Zhe Liu, Mingchun Li*. Different toxicity of anatase and rutile TiO2 nanoparticles on macrophages: Involvement of difference in affinity to proteins and phospholipids. Journal of Hazardous Materials, 2017, 335, 125-134. (2017-04-09)

4. Xiao Yi, Weili Zhao, Jianrong Li, Bing Zhang, Qilin Yu*, Mingchun Li*. Mn₃O₄ nanoparticles cause endoplasmic reticulum stress-dependent toxicity to Saccharomyces cerevisiae. RSC Advances, 2017,7(73), 46028-46035. (2017-09-28)

5. Jianrong Li, Bing Zhang, Tianyu Ma, Honggang Wang, Biao Zhang, Qilin Yu*, Mingchun Li*. (2017). Role of the inositol polyphosphate multikinase Ipk2 in regulation of hyphal development, calcium signaling and secretion in Candida albicans. Mycopathologia, 182(7-8), 609-623. (2017-05-13)