Zhouhao

Zhou hao, associate professor.Graduated from Hubei Agricultural University in 2003 with a bachelor's degree，major in Biotechnology; graduated from Nankai University in 2008 with a doctor's degree，major in biochemistry and molecular biology;in September 2008,work as a lecture in Nankai University;in December 2013, he was promoted to associate professor;In March 2017, as a visiting scholar,went to MD Anderson cancer center, university of Texas for research and study. The research direction is protein structure and function. Presided over 9 scientific research projects inluding the national natural science foundation of China, published numerous academic papers in international journals as first author or corresponding author,such as Nat. commun. PNAS, Cell Res, Cell Disc.and JMB. A member of the Chinese society of biochemistry and molecular biology.

1999.9-2003.6 Hubei Agricultural University, majored in biotechnology, obtained bachelor's degree; 2003.9-2008.6 Nankai University, majored in biochemistry and molecular biology, obtained doctor's degree;

2008.07-2013.12 Nankai university, life science college, lecturer; 2013.12-present Nankai university, life science college, associate professor, master tutor.

The structure and function study of protein related to tumor and other disease; Stucture-based protein engineering and applications.

Representative works in recent years：

1.Yanli Cheng, Zhongtian Shen, Yaqi Gao, Feilong Chen, Huisha Xu, Qinling Mo, Xinlei Chu, Chang-Liang Peng, Takese T McKenzie, Bridgitte E Palacios, Jian Hu, *Hao Zhou, *Jiafu Long. Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas. Nat Commun. 2022 May 18;13(1):2724.

2.﹟Feilong Chen, ﹟Beibei Liu, Jianwei Zeng, Lu Guo, Xuan Ge, Wei Feng, *De-Feng Li, *Hao Zhou, *Jiafu Long. Crystal Structure of the Core Module of the Yeast Paf1 Complex. J Mol Biol. 2022 Jan 30;434(2):167369.

3.﹟Feilong Chen, ﹟Beibei Liu, Lu Guo, Xuan Ge, Wei Feng, *De-Feng Li, *Hao Zhou, *Jiafu Long. Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated H2B monoubiquitination.Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2025291118.

4.﹟Chen Guidong, ﹟*Zhou Hao, Liu Beibei, Wang Yan, Zhao Jianchun, *Giancotti F. Giancotti, *Long Jiafu, A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex. Cell Discovery. pp1-5, 66(6). 2020/9.

5.﹟Xie, Ying; ﹟Zheng, Minying; Chu, Xinlei; Chen, Yue; Xu, Huisha; Wang, Jiawei; *Zhou, Hao; *Long, Jiafu, Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nature Communications. 9(1), pp 3795, 2018/9.

6.﹟Li, Youjun; ﹟Zhou, Hao; Li, Fengzhi; Chan, Siew Wee; Lin, Zhijie; Wei, Zhiyi;   Yang, Zhou; Guo, Fusheng; Lim, Chun Jye; Xing, Wancai; Shen, Yuequan; Hong, Wanjin; *Long, Jiafu; *Zhang, Mingjie, Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway, Cell Research, 25(7), pp 801-817, 2015/7.

Undergraduate teaching

Biochemical experiment (our institute): 2019 - present

Biochemical experiment (external institute): 2012-2016, 2019-present

Introduction to basic life science experiments: 2012-2016, 2019-present

Comprehensive experiment of Bioscience: 2019 - present

Postgraduate teaching

Advanced biochemistry: 2011-2016, 2019-present