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Zhanghongru |
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Gender: male Department: Biochemistry and Molecular Biology Tel: 18322065807 Office Location: Career: Professor Major: Biochemistry and Molecular Biology Email: hrzhang@nankai.edu.cn Address: 94 Weijin Rd, Nankai District, Tianjin, China, 300071 |
ResumeProfessor Hongru Zhang has long been dedicated to the study of the mechanisms of the immune regulation in TME and the development and application of CAR-T cell immunotherapies for cancer and autoimmune diseases. His research has been published in leading international journals, such as Nature Cancer, Cancer Immunology Research, Cell Metabolism, and Science Translational Medicine. His CAR-T research has been granted a U.S. patent. In 2019, he joined the American Association for Cancer Research (AACR) and became a member of the editorial boards of journals such as Molecular Therapy and Frontiers in Immunology. In 2023, he joined the School of Life Sciences at Nankai University as a professor.
Education2011-2017 M.Sc, Ph.D Nankai University
2006-2010 B.Sc Tianjin University
WorkExperience2023-now Professor, School of Life Sciences, Nankai University 2017-2022 Postdoc， Principal Research Investigator, University of Pennsylvania
Research Fields
AchievementSelected Publications: Hongru Zhang, Pengfei Yu, Vivek S. Tomar, Matthew J. Atherton, Zhen Lu, Angelica Ortiz, Jun Gui, N. Adrian Leu, Fangxue Yan, Andres Blanco, Mirella L. Meyer-Ficca, Ralph G. Meyer, Daniel P. Beiting, Jinyang Li, Selene Nunez-Cruz, Roddy S. O'Connor, Lexus R. Johnson, Andy J. Minn, Subin S. George, Constantinos Koumenis, J. Alan Diehl, Michael C. Milone, Hui Zheng, and Serge Y. Fuchs. Targeting ADP ribosylation to avert immunosuppression and improve CAR T therapy in solid tumors. Nature Cancer. 2022 Hongru Zhang, Vivek S. Tomar, Jinyang Li, Tara Lee Costich, Fangxue Yan, Jun Gui, Noreen McBrearty, Daniel P. Beiting, Andres Blanco, Jose R. Conejo-Garcia, Gurpanna Saggu, Allison Berger, Yulia Nefedova, Dmitry I. Gabrilovich, and Serge Y. Fuchs. Protection of the regulatory T cells from fragility in the tumor microenvironment. Cancer Immunology Research. 2022 Zheng W, Li S, Shi Z, Su K, Ding Y, Zhang L, Tang Q, Han J, Zhao H, Wang F, Zhang H*, Hong Z*. Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis. Journal of nanobiotechnology. 2024 Raghavendra Basavaraja, Hongru Zhang, A´ gnes Holczbauer, Zhen Lu, Enrico Radaelli, Charles-Antoine Assenmacher, Subin S. George, Vamshidhar C. Nallamala, Daniel P. Beiting, Mirella L. Meyer-Ficca, Ralph G. Meyer, Wei Guo, Yi Fan, Andrew J. Modzelewski, Vladimir S. Spiegelman, Michael S. Cohen, and Serge Y. Fuchs. PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies. Cell Reports Medicine. 2024 Zhen Lu , Noreen McBrearty, Jinyun Chen, Vivek S Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M Weljie, Daniel P Beiting, Zhen Miao, Subin S George, Allison Berger, Gurpanna Saggu, J Alan Diehl, Constantinos Koumenis, Serge Y Fuchs. ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes. Cell Metabolism. 2022 Eric S. Lightcap, Pengfei Yu, Stephen Grossman, Keli Song, Mithun Khattar, Kristina Xega, Xingyue He, James M. Gavin, Hisashi Imaichi, James J Garnsey, Erik Koenig, Hongru Zhang, Zhen Lu, Pooja Shah, Yu Fu, Michael A. Milhollen, Beryl A. Hatton, Jessica Riceberg, Vaishali Shinde, Cong Li, James Minissale, Xiaofeng Yang, Dylan England, Richard A. Klinghoffer, Steve Langston, Katherine Galvin, Gary Shapiro, Sai M. Pulukuri, Serge Y. Fuchs and Dennis Huszar. A small molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models. Science Translational Medicine. 2021 Jun Gui, Farima Zahedi, Angelica Ortiz, Christina Cho, Kanstantsin V. Katlinski, Kevin Alicea-Torres, Jinyang Li, Leslie Todd, Hongru Zhang, Daniel P. Beiting, Cindy Sander, John M. Kirkwood, Bryan E. Snow, Andrew C. Wakeham, Tak W. Mak, J. Alan Diehl, Constantinos Koumenis, Sandra W. Ryeom, Ben Z. Stanger, Ellen Puré, Dmitry I. Gabrilovich & Serge Y. Fuchs. Activation of p38α stress- activated protein kinase drives the formation of the pre-metastatic niche in the lungs. Nature Cancer. 2020 Social AppointmentsTeaching ExperienceHonor Title |
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