周军

周军，南开大学生命科学学院遗传学和细胞生物学系教授、药物化学生物学国家重点实验室课题组长。陆续担任南开大学生命科学学院遗传学和细胞生物学系主任、生命科学学院副院长，美国佐治亚理工学院生物医学工程系访问教授，山东师范大学生物学学科负责人等。担任中国细胞生物学学会资深理事，中国遗传学会理事，天津市细胞生物学学会理事长，Journal of Cellular Physiology副主编以及Journal of Genetics and Genomics、Acta Pharmacologica Sinica等刊物的编委。主要从事细胞骨架、发育和疾病方面的研究。先后主持国家自然科学基金重点项目、科技部重点研发计划课题等，作为通讯作者在Developmental Cell、Cell Research、Protein & Cell、Journal of Cell Biology、Nature Communications、Blood、PNAS、STTT等期刊上发表了一系列论文，并主编了《Microtubule Protocols》一书。先后获得国家杰出青年科学基金、霍英东青年教师基金、霍英东青年教师奖一等奖、泰山学者学科领军人才、南开大学杰出教授等荣誉。

先后就读于复旦大学、北京大学和美国埃默里大学。

先后于美国基因泰克公司和埃默里大学进行科研训练，回国工作后任南开大学生命科学学院遗传学和细胞生物学系教授、药物化学生物学国家重点实验室课题组长。陆续担任南开大学生命科学学院遗传学和细胞生物学系主任、生命科学学院副院长，美国佐治亚理工学院生物医学工程系访问教授，山东师范大学生物学学科负责人等。

主要从事细胞骨架、发育和疾病方面的研究，包括：(1)细胞骨架在细胞分裂和运动中的动态行为及其在组织器官发育中的功能；(2)纤毛稳态的调控及其生理病理功能；(3)肿瘤等疾病发生发展的细胞骨架基础和信号转导机制。

 

[1]   Yu F, Li T, Sui Y, Chen Q, Yang S, Yang J, Hong R, Li D, Yan X, Zhao W, Zhu X, Zhou J. (2020). O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis. Protein Cell doi: 10.1007/s13238-020-00746-2.

[2]   Xie W, Li D, Dong D, Li Y, Zhang Y, Duan L, Liu X, Meng W, Liu M, Zhou J. (2020). HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions. Signal Transduct Target Ther 5:79.

[3]   Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J. (2020). ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Dev Cell 53:287-299.

[4]   Zhang Z, Xie S, Wang R, Guo S, Zhao Q, Nie H, Liu Y, Zhang F, Chen M, Liu L, Meng X, Liu M, Zhao L, Colaiacovo MP, Zhou J, Gao J. (2020). Multivalent weak interactions between assembly units drive synaptonemal complex formation. J Cell Biol 219:e201910086.

[5]   Du X, Zhang Z, Zheng X, Zhang H, Dong D, Zhang Z, Liu M, Zhou J. (2020). An electrochemical biosensor for the detection of epithelial-mesenchymal transition. Nat Commun 11:192.

[6]   Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X, Zhou J. (2019). Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res 29:171-173.

[7]   Yang Y, Hao H, Wu X, Guo S, Liu Y, Ran J, Li T, Li D, Liu M, Zhou J. (2019). Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport. Cell Discov 5:33.

[8]   Chen S, Han C, Miao X, Li X, Yin C, Zou J, Liu M, Li S, Stawski L, Zhu B, Shi Q, Xu ZX, Li C, Goding CR, Zhou J, Cui R. (2019). Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads. Nat Commun 10:877.

[9]   Yan B, Xie S, Liu Y, Liu W, Li D, Liu M, Luo HR, Zhou J. (2018). Histone deacetylase 6 modulates macrophage infiltration during inflammation. Theranostics 8:2927-2938.

[10]  Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z, Wan L, Zhang X, Zhang J, Lian CG, Ma P, Xu ZX, Prince S, Wang T, Gao X, Shi Y, Liu D, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward NK, Goding CR, Chen X, Zhou J, Cui R. (2018). The protective role of DOT1L in UV-induced melanomagenesis. Nat Commun 9:259.

[11]  Xie W, Yang Y, Gao S, Song T, Wu Y, Li D, Liu M, Zhou J. (2017). The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly. J Genet Genomics 44:343-353.

[12]  Yu F, Ran J, Zhou J. (2016). Ciliopathies: does HDAC6 represent a new therapeutic target? Trends Pharmacol Sci 37:114-119.

[13]  Luo Y, Ran J, Xie S, Yang Y, Chen J, Li S, Shui W, Li D, Liu M, Zhou J. (2016). ASK1 controls spindle orientation and positioning by phosphorylating EB1 and stabilizing astral microtubules. Cell Discov 2:16033.

[14]  Zhang Y, Luo Y, Lyu R, Chen J, Liu R, Li D, Liu M, Zhou J. (2016). Proto-oncogenic Src phosphorylates EB1 to regulate the microtubule-focal adhesion crosstalk and stimulate cell migration. Theranostics 6:2129-2140.

[15]  Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J. (2014). CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res 24:1342-1353.

[16]  Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, Sun SC, Zhou J. (2014). CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A 111:2158-2163.

[17]  Gao J, Sun L, Huo L, Liu M, Li D, Zhou J. (2010). CYLD regulates angiogenesis by mediating vascular endothelial cell migration. Blood 115:4130-4137.

担任中国细胞生物学学会资深理事，中国遗传学会理事，天津市细胞生物学学会理事长，Journal of Cellular Physiology副主编以及Journal of Genetics and Genomics、Acta Pharmacologica Sinica等期刊的编委。

主讲《细胞生物学》本科生课程、《细胞生物学进展》博士生课程等。

先后获得国家杰出青年科学基金、霍英东青年教师基金、霍英东青年教师奖一等奖、泰山学者学科领军人才、南开大学杰出教授等荣誉。