染色质高级结构在肿瘤增殖、抗药性、肿瘤干细胞干性维持等方面的作用

Zhang, L.# *, He, A.#, Chen, B., Bi, J., Chen, J., Guo, D., Qian, Y., Wang, W., Shi, T., Zhao, Z., Shi, J., An, W., Attenello, F., and Lu, W. * (2020). A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes. Genome Research 30, 155-163. (#Co-first authors, *Corresponding authors)

Qian, Y.#, Zhang, L.#, Cai, M., Li, H., Xu, H., Yang, H., Zhao, Z., Rhie, S. K., Farnham, P. J., Shi, J., and Lu, W. (2019). The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression. Science Advances 5, eaaw6710. (#Co-first authors)

Su, G. #, Wang, W. #, Zhao, X. #, Chen, J., Zheng, J., Liu, M., Bi, J., Guo, D., Chen, B., Zhao, Z., Shi, J., Zhang, L.*, and Lu, W*. (2021). Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs. Nucleic acids research.

Chen, B., Ma, Y., Bi, J., Wang, W., He, A., Su, G., Zhao, Z., Shi, J., and Zhang, L.* (2021). Regulation Network of Colorectal-Cancer-Specific Enhancers in the Progression of Colorectal Cancer. International journal of molecular sciences 22.

Su, G., Wang, W., Chen, J., Liu, M., Zheng, J., Guo, D., Bi, J., Zhao, Z., Shi, J., Zhang, L. *, and Lu, W. * (2021). CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA. Journal of Biological Chemistry 296, 100413.

Chen, B. #, He, A. #, Bi, J., Sun, S., Ma, Y., Wang, W., Guo, D., Chen, J., Qian, Y., Shi, T., Nie, G., Zhao, Z., Shi, J., Yang, H., Zhang, L.*, and Lu, W.* (2021). Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide. Journal of genetics and genomics 48, 946-949.

Zheng, J. #, Su, G. #, Wang, W., Zhao, X., Liu, M., Bi, J., Zhao, Z., Shi, J., Lu, W., and Zhang, L.* (2021). Two Enhancers Regulate HoxB Genes Expression During Retinoic Acid-Induced Early Embryonic Stem Cells Differentiation Through Long-Range Chromatin Interactions. Stem cells and development 30, 683-695.

Chen, S., Chen, B., Su, G., Chen, J., Guo, D., Yin, Q., Wang, W., Zhao, Z., Zhang, L. *, Shi, J. *, and Lu, W. * (2020). Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling. Stem Cell Research 49, 102097.

Shi, T., Guo, D., Xu, H., Su, G., Chen, J., Zhao, Z., Shi, J., Wedemeyer, M., Attenello, F., Zhang, L.*, and Lu, W*. (2020). HOTAIRM1, an enhancer lncRNA, promotes glioma proliferation by regulating long-range chromatin interactions within HOXA cluster genes. Molecular Biology Reports 47, 2723-2733.

Zhang, L., Niu, T., Huang, Y., Zhu, H., Zhong, W., Lin, J., and Zhang, Y. (2015). Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20. Scientific Reports 5, 12003.

Zhang, L., and Zhang, Y. (2015). Tunneling nanotubes between rat primary astrocytes and c6 glioma cells alter proliferation potential of glioma cells. Neuroscience Bulletin 31, 371-378.

Zhang, L., and Zhang, Y. (2013). Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax. International journal of clinical and experimental medicine 6, 452-460.

Su, G., Guo, D., Chen, J., Liu, M., Zheng, J., Wang, W., Zhao, X., Yin, Q., Zhang, L., Zhao, Z., Shi, J., and Lu, W. (2019). A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation. Nucleic Acids Research 47, 6737-6752.

Ma, H., Zhang, Y., Wang, H., Han, C., Lei, R., Zhang, L., Yang, Z., Rao, L., Qing, H., Xiang, J., and Deng, Y. (2013). Effect and mechanism of Mitomycin C combined with recombinant adeno-associated virus type II against glioma. International journal of molecular sciences 15, 1-14.

2016年入选天津市“131”创新型人才培养工程

2019年全国高等学校细胞生物学青年教师讲课比赛二等奖