染色质高级结构在肿瘤增殖、抗药性、肿瘤干细胞干性维持等方面的作用

Zhang, L.# *, He, A.#, Chen, B., Bi, J., Chen, J., Guo, D., Qian, Y., Wang, W., Shi, T., Zhao, Z., Shi, J., An, W., Attenello, F., and Lu, W. * (2020). A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes. Genome Research 30, 155-163. (#Co-first authors, *Corresponding authors)

Qian, Y.#, Zhang, L.#, Cai, M., Li, H., Xu, H., Yang, H., Zhao, Z., Rhie, S. K., Farnham, P. J., Shi, J., and Lu, W. (2019). The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression. Science Advances 5, eaaw6710. (#Co-first authors)

Shi, T. #, Guo, D. #, Zheng, Y., Wang, W., Bi, J., He, A., Fan, S., Su, G., Zhao, X., Zhao, Z., Song, Y., Sun, S., Li, P., Zhao, Z., Shi, J., Lu, W.*, Zhang, L.*(2024). Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide. Cell Death and Disease 15(1):6.

Bi, J.#, Wang, W.#, Zhang, M., Zhang, B., Liu, M., Su, G., Chen, F., Chen, B., Shi, T., Zheng, Y., Zhao, X., Zhao, Z., Shi, J., Li, P., Zhang, L.*, and Lu, W.* (2022). KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure. Nucleic Acids Research 50, 12235-12250. 

Su, G. #, Wang, W. #, Zhao, X. #, Chen, J., Zheng, J., Liu, M., Bi, J., Guo, D., Chen, B., Zhao, Z., Shi, J., Zhang, L.*, and Lu, W*. (2021). Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs. Nucleic Acids Research 49(20):11575-11595.

Shi, T. #, Guo, D. #, Zheng, Y., Wang, W., Bi, J., He, A., Fan, S., Su, G., Zhao, X., Zhao, Z., Song, Y., Sun, S., Li, P., Zhao, Z., Shi, J., Lu, W.*, Zhang, L.*(2024). Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide. Cell Death and Disease 15(1):6.

Su, G., Wang, W., Chen, J., Liu, M., Zheng, J., Guo, D., Bi, J., Zhao, Z., Shi, J., Zhang, L. *, and Lu, W. * (2021). CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA. Journal of Biological Chemistry 296, 100413.

Chen, B. #, He, A. #, Bi, J., Sun, S., Ma, Y., Wang, W., Guo, D., Chen, J., Qian, Y., Shi, T., Nie, G., Zhao, Z., Shi, J., Yang, H., Zhang, L.*, and Lu, W.* (2021). Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide. Journal of Genetics and Genomics 48, 946-949.

Chen, B., Ma, Y., Bi, J., Wang, W., He, A., Su, G., Zhao, Z., Shi, J., and Zhang, L.* (2021). Regulation Network ofColorectal-Cancer-Specific Enhancers in the Progression of Colorectal Cancer. International Journal of Molecular sciences 22.

Zheng, J. #, Su, G. #, Wang, W., Zhao, X., Liu, M., Bi, J., Zhao, Z., Shi, J., Lu, W., and Zhang, L.* (2021). Two Enhancers Regulate HoxB Genes Expression During Retinoic Acid-Induced Early Embryonic Stem Cells Differentiation Through Long-Range Chromatin Interactions. Stem Cells and Development 30, 683-695.

Chen, S., Chen, B., Su, G., Chen, J., Guo, D., Yin, Q., Wang, W., Zhao, Z., Zhang, L. *, Shi, J. *, and Lu, W. * (2020). Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling. Stem Cell Research 49, 102097.

Shi, T., Guo, D., Xu, H., Su, G., Chen, J., Zhao, Z., Shi, J., Wedemeyer, M., Attenello, F., Zhang, L.*, and Lu, W*. (2020). HOTAIRM1, an enhancer lncRNA, promotes glioma proliferation by regulating long-range chromatin interactions within HOXA cluster genes. Molecular Biology Reports 47, 2723-2733.

Bi, J.#, Mo, W.#, Liu, M.#, Song, Y., Xiao, Q., Fan, S., Wang, W., Shi, T., Zheng, Y., Lian, J., Liu, R., Chen, B., Huang, X., Li, P., Zhao, Z., Shi, J., Zhang, L., Su, G.*, Zhang, N.*, and Lu, W.*  (2025). Systematic decoding of functional enhancer connectomes and risk variants in human glioma. Nature Cell Biology.

Su, G.#, Chen, B.#, Song, Y. J., Yin, Q. Q., Wang, W. B., Zhao, X. Y., Fan, S. B., Lian, J., Li, D. Q., Bi, J. F., Li, P., Zhao, Z. F., Zhang, L., Shi, J., and Lu, W.* (2025). Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity. Nature Communications 16, 5540.

Su, G., Guo, D., Chen, J., Liu, M., Zheng, J., Wang, W., Zhao, X., Yin, Q., Zhang, L., Zhao, Z., Shi, J., and Lu, W. (2019). A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation. Nucleic Acids Research 47, 6737-6752.

Li, P.#, Yang, Y.#, Luan, C., Wang, W., Jiang, Y., Zhao, Z., Wang, B., Zhao, Y., Bai, Y., Liu, M., Zhao, Z., Zhang, L., Qian, Y.*, and Shi, J.*(2025). A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST. Oncogenesis 14, 8. 

Zhang, L., Niu, T., Huang, Y., Zhu, H., Zhong, W., Lin, J., and Zhang, Y. (2015). Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20. Scientific Reports 5, 12003.

Zhang, L., and Zhang, Y. (2015). Tunneling nanotubes between rat primary astrocytes and c6 glioma cells alter proliferation potential of glioma cells. Neuroscience Bulletin 31, 371-378.

2016年 入选天津市“131”创新型人才培养工程

2019年 南开大学生命科学学院优秀青年科研工作者

2019年“全国高等学校细胞生物学青年教师讲课比赛”二等奖

2023年“第三届全国高校教师教学创新大赛”校级三等奖

2024年 校级优秀本科毕业论文指导教师

2020年“首届教师教学创新大赛”优秀奖