Zhangliyun

2009-12, Ph.D., Chemistry, University of Science and Technology of China 2005-07, B.S., Chemistry, Qilu University of Technology

09/2019-present, Professor, State key laboratory of medical chemical biology, Nankai University 02/2016-08/2019, Newton International Fellow, Department of chemistry, University of Oxford. 07/2015-02/2016 Associate research fellow, Department of chemistry, University of Illinois at Urbana-Champaign 10/2012-10/2013, Research Fellow, Department of chemistry, National University of Singapore 03/2012-07/2015, Associate Professor, Hefei Institutes of Physical Science, Chinese Academy of Sciences 12/2009-03/2012, Postdoctoral Fellow, National Synchrotron Radiation Laboratory, University of Science and Technology of China

(1) To develop an enzyme-based artificial photosynthesis system for light-driven hydrogen production, carbon dioxide conversion and organic chemicals biosynthesis;

(2) Design and develop novel aptamer-based biosensors for detection or imaging of biomarkers related to major diseases，such as cancers.

（1） Han, C.; Liu, Q.; Luo, X.; Zhao, J.; Zhang, Z.; He, J.; Ge, F.; Ding,W.; Luo, Z.; Jia, C.; Zhang, L.*, Development of aCRISPR/Cas12a-mediated Aptasensor for Mpox Virus Antigen Detection, Biosensorsand Bioelectronics 2024, 116313.

（2）Ge, F.; Ding, W.; Han, C.; Zhang, L.; Liu, Q.; Zhao, J.; Luo, Z.; Jia,C.; Qu, P.; Zhang, L.*, Electrochemical Sensor for the Detection andAccurate Early Diagnosis of Ovarian Cancer. ACS Sensors 2024, 9 (6), 2897-2906.

（3） Ji, H.; Wan, L.; Gao, Y.; Du, P.; Li, W.; Luo, H.; Ning, J.; Zhao, Y.;Wang, H.; Zhang, L.; Zhang, L.*, Hydrogenase as the basis for greenhydrogen production and utilization. Journal of Energy Chemistry 2023, 85,348-362.

（4）Han, C.; Xing, W.; Li, W.; Fang, X.; Zhao, J.; Ge, F.; Ding, W.; Qu, P.;Luo, Z.; Zhang, L.*, Aptamers dimerization inspired biomimetic clampassay towards impedimetric SARS-CoV-2 antigen detection. Sensors and ActuatorsB: Chemical 2023, 380, 133387.

（5） Wenjin Li; Yanxin Gao; Xuan Sun; Lei Wan; Haishuo Ji; Hang Luo; YaoTian; Hao Song; Geng Wu; Zhang, L.*, Direct Detection of aSingle [4Fe‐4S] cluster in a Tungsten‐containing Enzyme: Electrochemical Conversion of CO2into Formate by Formate Dehydrogenase. CarbonEnergy 2023,DOI:10.1002/cey2.304.

（6） Gao, Y.; Li, W.; Sun, X.; Zhao, Y.; Ji, H.; Luo, H.; Wu, G.; Wan, L.; Zhang,L.*, Boosting the Performance of Formate Dehydrogenase by SilverNanoclusters for Photoreduction of CO2 to Formate. ACS Sustainable Chemistry & Engineering 2022,10, 45, 14888–14896.

（7） Han,C.; Li, W.; Li, Q.; Xing, W.; Luo, H.; Ji, H.; Fang, X.; Luo, Z.; Zhang, L.*,Crispr/cas12a-derived Electrochemical Aptasensor for Ultrasensitive Detectionof COVID-19 Nucleocapsid Protein. Biosensorsand Bioelectronics 2022, 200, 113922.

（8）Wang, J.; Fang, X.; Zhang, C.; Ji, H.; Pang, Q.; Li, X.; Luo, Z.; Wu,Q.; Zhang, L.*, Development of Aptamer-Based Molecular Toolsfor Rapid Intraoperative Diagnosis and In Vivo Imaging of Serous OvarianCancer. ACS Applied Materials &Interfaces 2021, 13,16118-16126.

（9）Zhang, L.; Morello, G.; Carr, S. B.; Armstrong, F. A.*,Aerobic Photocatalytic H2 Production by a [NiFe] Hydrogenase Engineered toPlace a Silver Nanocluster in the Electron Relay. Journal of the American Chemical Society 2020, 142 (29),12699-12707.

（10）Zhang, L.; Can, M.; Ragsdale, S. W.; Armstrong, F. A.*,Fast and Selective Photoreduction of CO2 to CO Catalyzed by a Complex of CarbonMonoxide Dehydrogenase, TiO2, and Ag Nanoclusters. ACS Catalysis 2018, 8 (4), 2789-2795.

（11）Zhang, L.; Beaton, S. E.; Carr, S. B.; Armstrong, F. A.*,Direct Visible Light Activation of a Surface Cysteine-engineered[NiFe]-hydrogenase by Silver Nanoclusters. Energy& Environmental Science 2018,11 (12), 3342-3348.

 

Chemical biology