Zhang Xiaodong

2014-2019 Publications：

1.Yang G, Feng J, Liu Y, Zhao M, Yuan Y, Yuan H, Yun H, Sun M, Bu Y, Liu L, Liu Z, Niu J, Yin M, Song X, Miao Z, Lin Z, Zhang XD. HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.Theranostics, 2019; 9(24):7345-7358

2.Feng J, Yang G, Liu Y, Gao Y, Zhao M, Bu Y, Yuan H, Yuan Y, Yun H, Sun M, Gao H, Zhang S, Liu Z, Yin M, Song X, Miao Z, Lin Z, Zhang X. LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer. Theranostics, 2019; 9(18): 5227-5245.

3.Liu Y, Feng J, Sun M, Yang G, Yuan H, Wang Y, Bu Y, Zhao M, Zhang S, Zhang X. Long non-coding RNA HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related hepatocellular carcinoma.Cancer Lett.2019 Jul 10;454:158-170. 

4.Liu YX, Feng JY, Sun MM, Liu BW, Yang G, Bu YN, Zhao M, Wang TJ, Zhang WY, Yuan HF, Zhang XD. Aspirin inhibits the proliferation of hepatoma cells through controlling GLUT1-mediated glucose metabolism.Acta Pharmacol Sin. 2019 Jan;40(1):122-132.

5.Yang Z, Li J, Feng G, Wang Y, Yang G, Liu Y, Zhang S, Feng J, Zhang X. Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting ofNUSAP1 mRNA by miR-18b. Cancer Biol Med. 2019 May;16(2):276-287. 

6.Li H, Wang Z, Li Y, Fang R, Wang H, Shi H, Zhang X, Zhang W, Ye L. Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells. J Biol Chem.2018 Feb 9;293(6):2053-2065.

7.Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W, Ye L. HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. Cancer Lett.2018 Feb 28;415:11-19.

8.Gao Y, Feng JY, Yang G, Zhang SQ, Liu YX, Bu YN, Chen FQ, Zhang WY, YeLH*, Zhang XD*. HBx-elevated MSL2 modulates HBV cccDNA through inducing degradation of APOBEC3B to enhance hepatocarcinogenesis. Hepatology, 2017 Nov;66(5):1413-1429.

9.Feng GX, Li J, Yang Z, Zhang,SQ, Liu YX,Zhang WY, Ye LH* and Zhang XD*.Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through down-regulation of miR-30e targeting P4HA2 mRNA. Oncogene,2017 Dec 14;36(50):6895-6905

10.Wang Y, Chen FQ, Zhao M, Yang Z, Li J, Zhang SQ, Zhang WY, Ye LH* and Zhang XD*. The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA miR-186. J Biol Chem.2017 Sep 15;292(37):15395-15407

11.Zhang SQ, Yang Z, Cai XL, Zhao M, Sun MM, Li J, Feng GX, Feng JY_,Ye LH, Niu JQ, and Zhang XD*.MiR-511 promotes proliferation of hepatoma cells via targeting B cell translocation gene 1 (BTG1) mRNA 3'UTR. Acta Pharmacol Sin.2017 Aug;38(8):1161-1170

12.Wang Y, Chen FQ, Yang Z, Zhao M, Zhang SQ, Gao YE,Feng JY, Yang G, Zhang WY, Ye LH* and Zhang XD* The fragment HMGA2-sh-3p20 from HMGA2 mRNA 3¢UTR promotes the growth of hepatoma vells by upregulating HMGA2. Scientific Reports.2017 May 18;7(1):2070

13.Yang G, Wang Y, Feng J, Liu Y, Wang T, Zhao M, Ye L, Zhang X*. Aspirin suppresses the abnormal lipid metabolism in liver cancer cells via disrupting an NFκB-ACSL1 signaling. Biochem Biophys Res Commun. 2017 May 6;486(3):827-832.

14.Zhang S, Gao S, Zhao M, Liu Y, Bu Y, Jiang Q, Zhao Q, Ye L*, Zhang X*.Anti-HBV drugs suppress the growth of HBV-related hepatoma cells via down-regulation of hepatitis B virus X protein.Cancer Lett.2017 Apr 28;392:94-104

15.Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun B, Zhang W, Zhang X*, Ye L*.HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer.Biochem Biophys Res Commun. 2017 Mar 11;484(3):565-571.

16.Yang Z, Li J, Feng G, Gao S, Wang Y, Zhang S, Liu Y, Ye L, Li Y*, Zhang X*. MicroRNA-145 modulates N⁶-methyladenosine levels by targeting the 3′-Untranslated mRNA region of the N⁶-methyladenosine–binding YTH domain family 2 protein.J Biol Chem. 2017 Mar 3;292(9):3614-3623

17.Wang Y, Cai X, Zhang S, Cui M, Liu F, Sun, Zhang W,Zhang X*, Ye L*. HBXIP up-regulates ACSL1 through activating transcriptional factor Sp1 in breast cancer.Biochem Biophys Res Commun. 2017 Mar 11;484(3):565-571.

18.Wang Y, Chen F, Zhao M, Yang Z, Ye L, Gao H*, and Zhang X*. MiR-107 suppresses proliferation of hepatoma cells through targeting HMGA2 mRNA 3′UTR.Biochem Biophys Res Commun. 2016:480(3):455-460

19.Wang Y, Fang R, Cui M, Zhang W, Bai X, Wang H, Liu B, Zhang X*, Ye L*. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer.Cancer Lett.2017 Jan 28;385:234-242.

20.Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, Chen F, Zhang S,Zhang X*, Ye L*. The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells. Cancer Lett.2016 ； 382（2）：147-156

21.Gao Y, Wang Y, Chen F, Feng J, Yang G, Feng G, Yang Z, Ye L*, Zhang X*. An esiRNA cleaved from a hairpin within PTEN mRNA 3¢UTR modulates protein phosphatase PPP2CA and PTEN in liver cells Acta Pharmacol Sin.2016；37（7）：898-907

22.Feng G, Li J, Zheng M, Yang Z, Liu Y, Zhang S, Ye Y, Zhang W, Zhang XD*. Hepatitis B virus X protein up-regulates C4b-binding proteinαthrough activating transcription factor Sp1 in protection of hepatoma cells from complement attack. Oncotarget,2016； 7（19）：28013-26

23.Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F,Zhang X*, and Ye LH*. The Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism of Breast Cancer through Activating LXRs/SREBP-1c/FAS Signaling. Cancer Res.2016, Mar 15,76(16):4696-707

24.Feng G, Shi H, Li J, Yang Z, Fang R, Ye L, Zhang W, Zhang X*. MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Biochem Biophys Res Commun. 2016; 472(3):516-22

25.Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X*, Ye L*.The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.Biochem Biophys Res Commun. 2016; 471(1)89-94.

26.Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X*, Ye L*. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.Cancer Res.2016 Jan 15;76(2):293-304.

27.Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X*, Ye L*Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.Oncogene. 2016;35(31): 4048-57

28.Lu Z, Zhang W, Gao S, Jiang Q, Xiao Z, Ye L*, Zhang X*. MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA.Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):8-13.

29.Lu Z, Xiao Z, Liu F, Cui M, Li W, Yang Z, Li J, Ye L, Zhang X. Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1).Oncotarget. 2016 Jan 5;7(1):241-54.

30.Liu F, Zhang W, You X, Liu Y, Li Y,Wang Z, Wang Y, Zhang X*, Ye L*. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.Oncotarget.2015 Sep 29;6(29):27199-213.

31.Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X*, Ye L*. The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Growth of Breast Cancer.J Biol Chem.2015;290(37):22649-61.

32.Lu ZP, Xiao ZL, Yang Z,Li J, Feng GX, Chen FQ,Li YH, Feng JY, Gao YE, Ye LH, Zhang XD. Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2α and sphingosine kinase 1. Acta Pharmacol Sin.2015；36(10):1228-36.

33.Zhang W, Lu Z, Gao Y, Ye L, Song T, Zhang X. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. Biochem Biophys Res Commun.2015; 460(3):793-8.

34.Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang Z, Xiao Z, Lu Z, Ye LH, Zhang XD. A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level. Biochem Biophys Res Commun. 2015; 459(2):306-12

35.Li L, Liu B, Zhang XD, Ye LH. The oncoprotein HBXIP promotes migration of breast cancer cells via GCN5-mediated microtubule acetylation. Biochem Biophys Res Commun. 2015; 458(3):720-5

36.Cui M, Zheng M, Sun B, Wang Y, Ye Lh and Zhang XD. A long non-coding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis. Neoplasia, 2015;17(1):79-88 (IF=5.4)

37.Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang XD. Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9–Mediated RXRA Signaling Pathway. Cancer Res, 2015;75（5）: 846-857 (IF=9.2)

38.Zhang XD, Wang Y, Ye LH. Hepatitis B virus X protein accelerates the development of hepatoma.Cancer Biol Med. 2014;11(3):182-90.

39.Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang XD, Ye LH.The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Cancer Letters,2014;355:288-296(IF=5.0)

40.Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH.MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR. Acta Pharmacol Sin.2014;35(9):1207-14. (IF=2.1)

41.Zhang W, Lu Z，Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye L and Zhang X*. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP.Molecular Cancer,2014, 13:128, (IF=5.1)

42.Wang Y, Cui M, Cai X, Sun B, Liu F, Zhang X, Ye LH*. The oncoprotein HBXIP up-regulates SCG3 via activating E2F1 and suppressing miR-509-3p to promote proliferation of hepatoma cells. Cancer Letters, 2014, 352(2):169-78. (IF=5.0)

43.Xu F, Zhu X, Han T, You X, Liu F, Ye L, Zhang X, Wang X, Yao Y. The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1. Int J Oncol. 2014, 45(1):255-63.

44.Cui M, Xiao Z, Sun B, Wang Y, Zheng M, Ye L, Zhang XD*. Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. Biochem Biophys Res Commun., 2014;445(3):651-5. (IF=2.7)

45.Liu FB, You XN, Wang Y, Liu Q,Liu YX, Zhang SQ, Chen LY,Zhang XD, Ye LH. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer throughmodulating FGF8 and VEGF. Carcinogenesis2014;35(5):1144-53. (IF-5.4)

46.Cui M, Wang Y, Sun B, Xiao Z, Ye LH, Zhang XD. MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA. Biochem Biophys Res Commun., 2014;444: 270-275 (IF=2.7)

47.Liu FB, You XN, Chi YM, Wang T, Ye LH, Niu JQ, Zhang XD.Hepatitis B virus X protein mutant HBxD127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Biochem Biophys Res Commun., 2014;444: 128-134 (IF=2.7)