代表论文:
1. Hou J, Pan Y, Zhu D, Fan Y, Feng G, Wei Y, Wang H, Qin K, Zhao T, Yang Q, Zhu Y, Che Y, Liu Y, Cheng J*, Kong D, Wang PG, Shen J*, Zhao Q*. Targeted delivery of nitric oxide via a “bump-and-hole”-based enzyme-prodrug pair. Nat Chem Biol 2019, 15: 151-60 (recommended by F1000).
2. Zhu D, Hou J, Qian M, Jin D, Hao T, Pan Y, Wang H, Wu S, Liu S, Wang F, Wu L, Zhong Y, Yang Z, Che Y, Shen J, Kong D, Yin M*, Zhao Q*. Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery. Nat Commun 2021, 12: 4501.
3. Wang F, Qin K, Wang K, Wang H, Liu Q, Qian M, Chen S, Sun Y, Hou J, Wei Y, Hu Y, Li Z, Xu Q*, Zhao Q*. Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells. Cell Rep 2022, 39:110981.
4. Midgley AC, Wei Y, Li Z, Kong D, Zhao Q*. Nitric oxide–releasing biomaterial regulation of the stem cell microenvironment in regenerative medicine. Adv Mater 2020, e1805818.
5. Hao T, Qian M, Zhang Y, Liu Q, Midgley AC, Liu Y, Che Ye, Hou J, Zhao Q*. An injectable dual-function hydrogel protects against myocardial ischaemia/reperfusion injury by modulating ROS/NO disequilibrium. Adv Sci 2022, 9: 2105408.
6. Pan Y, Yang J, Wei Y, Wang H, Jiao R, Moraga A, Zhang Z, Hu Y, Kong D, Xu Q, Zeng L*, Zhao Q*. Histone deacetylase 7-derived peptides play a vital role invascular repair and regeneration. Adv Sci 2018, 5:1800006.
7.Issa Bhaloo S, Wu Y, Le Bras A, Yu B, Gu W, Xie Y, Deng J, Wang Z, Zhang Z, Kong D, Hu Y, Qu A, Zhao Q*, Xu Q*. Binding of Dickkopf-3 to CXCR7 enhances vascular progenitor cellmigration and degradable graft regeneration. Circ Res 2018, 123:451-66.
8. Feng G, Zhang J, Li Y, Nie Y, Zhu D, Wang R, Liu J, Gao J, Liu N, He N, Du W, Tao H, Xu Y*, Kong D, Zhao Q*, Li Z*. IGF-1C modified hydrogel enhances cell therapy for acute kidney injury. J Am Soc Nephrol 2016, 27: 2357-69. (with editorial and recommended by F1000)
9. Qin K, Wang F, Simpson RML, Zheng X, Wang H, Hu Y, Gao Z, Xu Q*, Zhao Q*. Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts. Biomaterials 2020, 257:120226.
10. Wei Y, Wu Y, Zhao R, Zhang K, Midgley AC, Kong D, Li Z*, Zhao Q*. MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. Biomaterials2019, 204:13-24.
11. Du W, Zhang K, Zhang S, Wang R, Nie Y, Tao H, Han Z, Liang L, Wang D, Liu J, Liu N, Han Z, Kong D, Zhao Q*, Li Z*. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomesstimulated by a nitric oxide releasing polymer. Biomaterials2017, 133:70-81.
12.Yao X, Liu Y, Gao J, Yang L, Mao D, Stefanitsch C, Li Y, Zhang J, Ou L, Kong D, Zhao Q*, Li Z*. Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials 2015, 60: 130-40.
13. Wang Z, Cui Y, Wang J, Yang X, Wu Y, Wang K, Gao X, Li D, Li Y, Zheng X, Zhu Y, Kong D*, Zhao Q*. The effect of thick fibers and large pores of electrospun poly(ε-caprolactone) vascular grafts on macrophage polarization and arterial regeneration. Biomaterials 2014, 35: 5700-10.
14. Zhao Q, Zhang J, Song L, Ji Q, Yao Y, Cui Y, Shen J*, Wang P, Kong D*. Polysaccharide-based biomaterials with on-demand nitric oxide releasing property regulated by enzyme catalysis. Biomaterials 2013, 34: 8450-8.
15.Zheng W, Wang Z, Song L, Zhao Q*, Zhang J, Li D, Wang S, Zheng X, Han J, Yang Z, Kong D*. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials 2012, 33: 2880-91.
16. Wang H, Xing M, Deng W, Qian M, Wang F, Wang K, Midgley AC*, Zhao Q*. Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells. Bioact Mater 2022, 16: 433-50.
17.Qian M, Liu Q, Wei Y, Guo Z, Zhao Q*. In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents.Bioact Mater 2020, 11:1464-7.
18. Wang Z, Lu Y, Qin K, Tian Y, Wang J, Zhang J, Cui Y, Wu Y, Hou J, Shen J, Xu Q, Kong D, Zhao Q*. Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug. J Control Release 2015, 210: 179-88.
19. Wang W, Song H, Zhang J, Li P, Li C*, Wang C, Kong D, Zhao Q*. An injectable, thermosensitive and multicompartment hydrogel for simultaneous encapsulation and independent release of a drug cocktail as an effective combination therapy platform. J Control Release, 2015, 203: 57-66.
20.Cao X, Duan L, Hou H, Liu Y, Chen S, Zhang S, Liu Y, Wang C, Qi X, Liu N, Han Z, Zhang D, Han ZC, Guo Z*, Zhao Q*, Li Z*. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization. Theranostics 2020, 10:7697-709.
21. Zhang K, Chen X, Li H, Feng G, Nie Y, Wei Y, Li N, Han Z, Han ZC, Kong D, Guo Z, Zhao Q*, Li Z*. A nitric oxide-releasing hydrogel for enhancing the therapeutic effects of mesenchymal stem cell therapy for hindlimb ischemia. Acta Biomater 2020, 113: 289-304.
22. Zhang Y, Zhu D, Wei Y, Wu Y, Cui W, Liuqin L, Fan G, Yang Q, Wang Z, Xu Z*, Kong D, Zeng L*, Zhao Q*. A collagen hydrogel loaded with HDAC7-derived peptide promotes the regeneration of infarcted myocardium with functional improvement in a rodent model.Acta Biomater 2019, 86:223-34.
23. Zhou X, Wang H, Zhang J, Li X, Wu Y, Wei Y, Ji S, Kong D*, Zhao Q*.Functional poly(ε-caprolactone)/chitosan dressings with nitric oxide-releasing property improve wound healing. Acta Biomater 2017, 54: 128-37.
24. Yao Y, Wang J, Cui Y, Xu R, Wang Z, Zhang J, Wang K, Li Y, Zhao Q*, Kong D. Effect of sustained heparin release from PCL/Chitosan hybrid small-diameter vascular grafts on the anti-thrombogenic property and endothelialization. Acta Biomater 2014, 10:2739-49.
25.Lou S, Gao S, Wang W, Zhang M, Zhang J, Wang C, Li C*, Kong D, Zhao Q*. Galactose-functionalized multi-responsive nanogels for hepatoma-targeted drug delivery. Nanoscale 2015, 7: 3137-46.
26. Liu Q, Ji G, Chu Y, Hao T, Qian M*, Zhao Q*. Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy.Chem Commun 2022, in press, DOI: 10.1039/D2CC02267B.
27.Gao J, Zheng W, Zhang J, Guan D, Yang Z*, Kong D, Zhao Q*. Enzyme-controllable delivery of nitric oxide from a molecular hydrogel.Chem Commun 2013, 49:9173-5.
28.Ji Q, Zhang S, Zhang J, Wang Z, Wang J, Cui Y, Pang L, Wang S, Kong D, Zhao Q*. Dual functionalization of poly(ε-caprolactone) (PCL) film surface through supramolecular assembly with the aim of promoting in-situ endothelial progenitor cell attachment on vascular grafts. Biomacromolecules 2013, 14: 4099-107.
29. Zhao Q, Wang S, Cheng X, Yam RCM, Kong D*, Li RKY*. Surface modification of cellulose fiber via supramolecular assembly of biodegradable polyesters by the aid of host-guest inclusion complexation. Biomacromolecules 2010, 11: 1364-9.
30. Midgley AC*, Zhao Q*. CD44 receptor diversity and potential in preventative and regenerative therapies. Clin Transl Discov 2022, 2:e78.
31. Wei Y, Wang F, Guo Z, Zhao Q*. Tissue-engineered vascular grafts and regeneration mechanisms. J Mol Cell Cardiol 2022, 165: 40-53.
32.Yang S, Zheng X, Qian M, Wang H, Wang F, Wei Y, Midgly AC*, He J, Tian H*, Zhao Q*. Nitrate-functionalized poly(ε-caprolactone) small-diameter vascular grafts enhance vascular regeneration via local delivery of nitric oxide. Front Bioeng Biotechnol 2021, 9:770121.
33. Yang S, Huan J, Qian M, Ji G, Wei Y*, He J, Tian H*, Zhao Q*. MSC-derived sEV-loaded hyaluronan hydrogel promotes scarless skin healing by immunomodulation in a large skin wound model. Biomed Mater 2022, 7: 034104.
34. Pan Y, Zhou X, Wei Y, Zhang Q, Wang T, Zhu M, Li W, Huang R, LiuR, Chen J, Fan G, Wang K*, Kong D, Zhao Q*. Small-diameter hybrid vascular grafts composed of polycaprolactone and polydioxanone fibers. Sci Rep 2017, 7: 3615.
35.Zhang J, Wang J, Wei Y, Gao C, Chen X, Kong W, Kong D*, Zhao Q*. ECM-mimetic heparin glycosamioglycan-functionalized surface favors constructing functional vascular smooth muscle tissue in vitro. Colloids Surf B: Biointerfaces 2016, 146: 280-8.
36.Zhou X, Zhang J, Feng G, Shen J, Kong D*, Zhao Q*.Nitric oxide-releasing biomaterialsfor biomedical applications. Curr Med Chem 2016, 23: 2579-601.
37.Qin K, Wu Y, Pan Y, Wang K*, Kong D, Zhao Q*.Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model. J Vis Exp 2018, 136: e57340.
38.Wang K, Chen X, Pan Y, Cui Y, Zhou X, Kong D, Zhao Q*. Enhanced vascularization in hybrid PCL/gelatin fibrous scaffolds with sustained release of VEGF. BioMed Res Int 2015, Article ID 865076.
39.Zhao Q, Li Z*. Angiogenesis. BioMed Res Int 2015, Article ID 135861.
40. Li Q, Wang Z, Zhang S, Zheng W, Zhao Q*, Zhang J, Wang L*, Wang S, Kong D. Functionalization of the surface of electrospun poly(epsilon-caprolactone) mats using zwitterionic poly(carboxybetaine methacrylate) and cell-specific peptide for endothelial progenitor cells capture. Mater Sci Eng C-Mater Biol Appl 2013, 33: 1646-53.
41. Zhang M, Wang K, Wang Z, Xing B, Zhao Q*, Kong D*. Small-diameter tissue engineered vascular graft made of electrospun PCL/Lecithin blend. J Mater Sci: Mater Med 2012, 23:2639-48.
42. Yang Z*, Zhao Q*, He Q*. Med Gas Res 2019, 9:170.
43.Zhao Q, Wang S*, Kong M, Geng W, Li RKY, Song C*, Kong D. Phase-morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends. J Biomed Mater Res 2012, 100B: 23-31.
44.Zhao Q, Zhang B, Quan H, Yam RCM, Yuen RKK, Li RKY*. Flame retardancy of rice husk-filled high-density polyethylene ecocomposites. Compos Sci Technol 2009, 69: 2675-81.
45. Zhao Q, Yam RCM, Zhang B, Yang Y, Cheng X, Li RKY*. Novel all-cellulose ecocomposites prepared in ionic liquids. Cellulose 2009, 16: 217-26. (Twenty most frequently requested scientific contributions in 2009)
46. Zhao Q, Tao J, Yam RCM, Mok ACK, Li RKY*, Song C*. Biodegradation behavior of polycaprolactone /rice husk ecocomposites in simulated soil medium. Polym Degrad Stab 2008, 93: 1571-6.
47. Zhao Q, Cheng G*, Song C, Zen Y, Tao J, Zhang L. Crystallization behavior and biodegradation of poly(3-hydroxybutyrate) and poly(ethylene glycol) multiblock copolymers. Polym Degrad Stab 2006, 91: 1240-6.
48. Zhao Q, Cheng G*, Li H, Ma X, Zhang L. Synthesis and Characterization of biodegradable poly(3-hydroxybutyrate) and poly(ethylene glycol) multiblock copolymers. Polymer 2005, 46: 10561-7.
49. Zhao Q, Cheng G*. Preparation of biodegradable poly(3-hydroxybutyrate) and poly(ethylene glycol) multiblock copolymers. J Mater Sci 2004, 39: 3829-31.
著作章节:
1. Zhao Q, Cheng G*. Biodegradable PHB/PEG derivatives and their degradation behavior. In: New Frontiers in Polymer Research Edited by Bregg RK. Nova Science Publishers Inc, New York, US, 2006, p99-124.
2. Zhao Q*. Applications of Injectable Smart Materials in Tissue Engineering. In: Smart Materials for Tissue Engineering: Applications, Edited by Wang Q. RSC, UK, 2017, p67-89.
3. Wang K, Cui W, Wei Y, Zhu M, Zhao Q, Kong D*. Regeneration of Blood Vessels. In: Polymeric Biomaterials for Tissue Regeneration, Edited by Gao C. Springer, Switzerland, 2016, p315-51.
4. Shafiq M, Yan H, Midgley AC, Wang K, Zhao Q, Kong D*. The Incorporation and Release of Bioactive Molecules in Vascular Grafts. In: Tissue-Engineered Vascular Grafts, Edited by Walpoth B H, et al. Springer Nature, Switzerland, 2020, p411-28.
5. Wang H, Zhao Q*. Fabrication and evaluation of tissue-engineered vascular grafts with hybrid fibrous structure. In: Vascular Tissue Engineering, Edited by Zhao F and Leong KW. Springer, Switzerland, 2020, in press.
6. 赵强,冯国伟,朱大帅,王飞,张然,叶开,李莉,高方莉,孔德领*. 《再生医学:生物材料与组织再生》第十八章—缺血性疾病的组织再生,付小兵,Nicholas A Peppas,顾晓松主编,人民卫生出版社,2021年9月.
授权专利:
1. 赵强,孔德领,张计敏,王淑芳. 酶催化可控释放一氧化氮的新型生物材料及其制备方法与应用, 中国发明专利, 专利号: ZL201310296773.4.
2. 赵强,侯静丽,王贺,钱盟,朱大帅,秦康. 一种硝酸酯可降解生物活性材料及其制备方法与应用, 中国发明专利, 专利号: ZL201810739149.X.
3. 赵强,李宗金,冯国伟,张计敏,孔德领. 结合IGF-1C 多肽的可注射性水凝胶,中国发明专利, 专利号: ZL201510767646.7.
奖励:
1. 孔德领,赵强,李宗金,杨志谋,丁丹,杨军,王淑芳,王恺,王玲,沈杰,张钧,生物活性材料在治疗缺血性疾病中的促血管再生作用,天津市自然科学一等奖, 2019年10月30日.
2. 赵强,柯亭羽,齐新,王连永,孔德领,李琦,贾文军,赵玲. 糖尿病并发心血管疾病新型疗法的基础与应用研究,天津市科技进步二等奖,2016年10月19日.
3. 李宗金,韩之波,齐新,刘娜,赵强,向荣,孔德领,范艳. 间充质干细胞及外泌体在组织再生中的应用与分子影像学评价,天津市科技进步二等奖,2021年12月.
4. 赵强. 南开大学第七届“良师益友”奖, 2016年7月.



