近五年来发表论文 (*: 通讯作者)
1. Yang X, Xiong L, Liu H, Shang T, Shen R, He S, Fan G, Wang Y, Jiang M, Zhang P, Gao X, Han J, Zhang J, Feng Y, Zhu Y. Novel phytoestrogen-like tetramethoxyflavone acts via estrogen receptor non-genomic effect to alleviate brain injuries in a murine ischemic stroke model. Frontiers in Pharmacology, section Ethnopharmacology. 2020, submitted.
2. Xu S, Ilyas I, Little PL, Li H, Kamato D, Zheng X, Luo S, Li Z, Liu P, Han J, Harding IC, Ebong EE, Cameron SC, Stewart AG, Weng J. Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies. Pharmacological Reviews. 2020, submitted.
3. Xie Z, Yang X, Duan Y, Han J, Liao C. Small-molecule kinase inhibitors for the treatment of nononcologic diseases. 2020. J Medicinal Chem, in revision.
4. Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, Wei Z, Yang X, Chen Y, Li X, Liao C, Han J, Miao QR*, Duan Y*. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem, 2021, in revision.
5. Yin Z, Wang X, Yang X, Chen Y, Duan Y*, Han J*. Salvia miltiorrhiza in anti-diabetic angiopathy. 2020. Current Molecular Pharmacology, accepted.
6. Ma C, Feng K, Yang X, Yang Z, Wang Z, Shang Y, Fan G, Liu L, Yang S, Li X, Han J, Duan Y*, Chen Y*. Targeting macrophage liver X receptor by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis. 2020. British Journal of Pharmacology, accepted.
7. Feng K, Ma C, Liu Y, Yang X, Yang Z, Chen Y, Xu T, Yang C, Zhang S, Li Q, Wei Z, Zhao D, Zeng P, Han J, Gao J*, Chen Y*, Duan Y*. Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances LXR anti-tumorigenic actions and removes LXR-induced lipogenesis. 2020. Theranostics 2020; doi:10.7150/thno.53139.
8. Wang X, Yin Z, Cao P, Zheng S, Chen Y, Yu M, Liao C, Zhang Z, Duan Y, Han J, Zhang S*, Yang X*. NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines. 2020. Biomed Pharmacother 2021;133:110964.
9. Yin Z, Wang X, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X*, Zhang S*. LongShengZhi Capsule attenuates Alzheimer-like pathology in APP/PS1 double transgenic mice by reducing neuronal oxidative stress and inflammation. 2020. Frontiers in Aging Neuroscience 2020;12:582455.
10. Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, Wang X, Chen Y, Li L, Zhang Z, Duan Y, Han J*, Yang X*. TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells. The Journal of Biological Chemistry. 2020;295:16314-16327.
11. Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J*, Duan Y*. Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. The Journal of Biological Chemistry. 2020;295:15870-15882.
12. Zhao D, Xue C, Li J, Feng K, Zeng P, Chen Y, Duan Y, Zhang S, Li X, Han J*, Yang X. Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress. Biochem Biophys Res Commun. 2020;533:304-312.
13. Zeng P, Yang J, Liu L, Yang X, Yao Z, Ma C, Zhu H, Su J, Zhao Q, Feng K, Yang S, Zhu Y, Li X, Wang W, Duan Y, Han J*, Chen Y*. ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway. Theranostics 2021;11:1129-1146.
14. Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y*, Han J*, Duan Y*. Reduced Nogo expression inhibits diet-induced hepatic metabolic disorders by regulating ChREBP and insulin activity. Journal of Hepatology, 2020;73:1482-1495.
15. Xu S, Wang Y, Yu M, Wang D, Liang Y, Chen Y, Liao C, Xie Z, Zhao B, Han J, Duan Y, Yang X. LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress. Biomedicine & Pharmacotherapy, 2020;123:109803.
16. Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y*, Chen Y*. Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. Cell Signalling, 2020;65:109429.
17. Orgah JO, He S, Wang Y, Jiang M, Wang Y, Orgah EA, Duan Y, Zhao B, Zhang B, Han J, Zhu Y. Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications. Pharmacol Res. 2020;153:104654.
18. Ma C, Xia R, Yang S, Liu L, Zhang J, Feng K, Shang Y, Qu J, Li L, Chen N, Xu S, Zhang W, Mao J, Han J, Chen Y, Yang X, Duan Y, Fan G. Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice. Theranostics. 2020;10:1090-1106.
19. Yang J, Zeng P, Liu L, Yu M, Su J, Yan Y, Ma J, Hu W, Yang X, Han J, Duan Y, Chen Y. Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun. 2020;524:439-445.
20. Zhang S, Yu M, Guo F, Yang X, Chen Y, Ma C, Li Q, Wei Z, Li X, Wang H, Hu H, Zhang Y, Kong D, Miao Q, Hu W, Hajjar DP, Zhu Y, Han J*, Duan Y*. Rosiglitazone alleviates a-naphthylisothiocyanate-induced intrahepatic cholestasis in mice – The role of circulating 15d-PGJ2 and Nogo. British Journal of Pharmacology 2020;177:1041-1060.
21. Yang J, Liu L, Yang X, Duan Y, Zeng P, Yang S, Ma C, Li X, Han J, Chen Y. Combination of MEK1/2 inhibitor and LXR ligand synergistically inhibit atherosclerosis in LDLR deficient mice. Biochemical and Biophysical Research Communications 2020;522:512-517.
22. Lv X, Yang X, Zhan MM, Cao P, Zheng S, Peng R, Han J, Xie Z, Tu Z, Liao C. Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold. European Journal of Medicinal Chemistry. 2019;184:111769.
23. Wei Z, Zhao D, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J*, Yang X*. Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-kB-TNF-a signaling pathway in a PPARg-dependent manner. Biochemical and Biophysical Research Communications 2019. 519: 854-860.
24. Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X*, Han J*. Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice. Biomedicine and Pharmacotherapy, 2019, 118:109389.
25. Xiao G, Lyu M, Wang Y, He S, Liu X, Ni J, Li L, Fan G, Han J, Gao X, Wang X, Zhu Y. Ginkgo flavonol glycosides or ginkgolides tend to differentially protect myocardial or cerebral ischemia-reperfusion injury via regulation of TWEAK-Fn14 signaling in heart and brain. Frontiers in Pharmacology. 2019;10:735.
26. Li Q, Chen Y, Zhao D, Yang S, Zhang S, Wei Z, Wang Y, Qian K, Zhao B, Zhu Y, Chen Y, Duan Y, Han J*, Yang X*. LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing endothelial inflammation and inactivating platelets. Pharmacological Research, 2019;144:167-180.
27. Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, Chen Y, Zhu Y, Gao X, Zhao B, Wang Y, Qian K, Li X, Duan Y, Han J*, Yang X*. LongShengZhi capsule reduces established atherosclerotic lesions in apoE deficient mice. Journal of Cardiovascular Pharmacology 2019;73:105-117.
28. Li S, Lv X, Cheng K, Tian Y, Huang X, Kong H, Duan Y, Han J, Liao C, Xie Z. Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors. Bioorg Med Chem Lett. 2019;29:1090-1093.
29. Cheng K, Li S, Lv X, Tian Y, Kong H, Huang X, Duan Y, Han J, Xie Z, Liao C. Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure. Bioorg Med Chem Lett. 2019;29:1012-1018.
30. Han J*, Tan H, Duan Y, Chen Y, Zhu Y, Zhao B, Wang Y, Yang X. The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule. Pharmacological Research, 2019;141:409-417.
31. Liang Y, Han H, Liu L, Duan Y, Yang X, Ma C, Zhu Y, Han J, Li X, Chen Y. CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells. Oncogenesis 2018;7:98.
32. Liu Y, Wei Z, Zhang Y, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Gu J, Liu J, Han J, Yang X, Duan Y. Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol. Journal of Lipid Research 2018;59:2287-2296 (封面论文并被美国生物化学与分子生物学学会新闻月刊ASBM Today专题报道).
33. Han H, Yang S, Liang Y, Zeng P, Liu L, Yang X, Duan Y, Han J, Chen Y. Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner. Biochemical and Biophysical Research Communications 2018;506:1040-1046.
34. Variya BC, Bakrania AK, Chen Y, Han J, Patel SS. Suppression of abdominal fat and anti-hyperlipidemic potential of Emblica officinalis: Upregulation of PPARs and identification of active moiety. Biomedicine and Pharmacotherapy 2018;108:1274-1281.
35. Liu L, Zeng P, Yang X, Duan Y, Zhang W, Ma C, Zhang X, Yang S, Li X, Yang J, Liang Y, Han H, Zhu Y, Han J*, Chen Y. Inhibition of vascular calcification—A new anti-atherogenic mechanism of DNA topoisomerase II inhibitors. Arteriosclerosis, Thrombosis and Vascular Biology 2018;38:2382-2395.
36. Li Q, Chen Y, Zhao D, Wei Z, Zhang S, Chen Y, Wang Y, Qian K, Zhao B, Zhu Y, Gao X, Li X, Duan Y, Han J*, Yang X*. NaoXinTong capsule inhibits carrageenan-induced thrombosis in mice. Journal of Cardiovascular Pharmacology 2018;72:49-59.
37. Yang, S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J*,Yang X*. NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice. Scientific Reports 2018;8:9158.
38. Ma C, Zhang W, Liu Y, Liu L, Yang X, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Miao QR, Zhu Y, Han J*, Chen Y*, Duan Y*. Functional interplay between LXR and AMPKa reduces inhibits atherosclerosis tic lesions in apoE knockout mice-deficient mice—A new anti-atherogenic strategy. British Journal of Pharmacology 2018;175:1486-1503.
39. Owoicho Orgah J, Wang M, Yang X, Wang Z, Wang D, Zhang Q, Fan G, Han J, Qin G, Gao X, Zhu Y. Danhong Injection protects against hypertension-induced renal injury via down-regulation of myoglobin expression in spontaneously hypertensive rats. Kidney Blood Press Research 2018;43:12-24.
40. Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Yu M, Ma C, Gu J, Miao RQ, Hajjar DP, Han J*, Duan Y*. 25-Hydroxycholesterol induces its own production by activating cholesterol 25-hydroxylase expression in an LXR dependent mechanism. Journal of Lipid Research 2018;59:439-451.
41. Zhang W, Yang X, Chen Y, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao QR*, Han J*, Duan Y*. Activation of hepatic Nogo-B receptor expression—A new anti-liver steatosis mechanism of statins. BBA-Molecular Cell Biology of Lipid 2018;1863:177-190.
42. Chen X, Feng Y, Shen X, Pan G, Fan G, Gao X, Han J, Zhu Y. Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis. Journal of Ethnopharmacology 2018;211:358-365.
43. Lyu M, Yan C, Liu H, Chen X, Wang Y, Han J, Fan G, Zhu Y. Network pharmacology exploration reveals endothelial inflammation as a common target for coronary artery disease and stroke treatment by Danhong injection. Scientific Reports 2017;7:15427.
44. Yang X, Orgah J, Wang D, Fan G, Jingyang H, Han J, Qin G, Gao X, Zhu Y. Danhong injection reduces vascular remodeling and up-regulates the Kallikrein-kinin system in spontaneously hypertensive rats. Scientific Reports 2017;7:4308.
45. Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao Q, Han J*, Duan Y*. Activation of adiponectin receptor regulates proprotein convertase subtilisin/kexin type 9 expression and inhibits lesions in apoE deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology 2017;37:1290-1300.
46. Yu M, Liu Y, Duan Y, Chen Y, Han J, Sun L, Yang X. Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis—a unique anti-oxidative stress mechanism in mice. Biochemical and Biophysical Research Communications 2017;484:56-63.
47. Yang X, Li Y, Sun L, Liu Y, Ma C, Chen Y, Tan H, Li Q, Li X, Wang Y, Duan Y, Zhao B*, Han J*. NaoXinTong enhances atorvastatin-reduced atherosclerosis while antagonizing atorvastatin-induced hepatic inflammation. Journal of Cardiovascular Pharmacology 2017;69:55-64.
48. He S, Zhao T, Guo H, Meng Y, Qin G, Goukassian DA, Han J, Gao X, Zhu Y. Coordinated activation of VEGF/VEGFR-2 and PPARd pathways by a multi-component Chinese medicine DHI accelerated recovery from peripheral arterial disease in type 2 diabetic mice. PLoS One. 2016;11:e0167305.
49. Zhang K, Cai HX, Gao S, Yang GL, Deng HT, Xu GC, Han J, Zhang QZ, Li LY. TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals. Oncotarget 2016;7:69436-69449.
50. Hu W, Zhang W, Chen Y, Rana U, Teng R, Duan Y, Liu Z, Zhao B, Foeckler J, Weiler H, Kallinger RE, Thomas MJ, Zhang K, Han J*, Miao QR*. Nogo-B receptor deficiency increases LXRa nuclear translocation and hepatic lipogenesis. Hepatology 2016;64:1559-1576.
51. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*. 2016. Inhibition of macrophage CD36 expression and cellular oxLDL accumulation by tamoxifen--A PPARg dependent mechanism. The Journal of Biological Chemistry 2016;291:16977-89 (封面论文).
52. Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Yajun Duan*. 2016 Activation of PPARg and CD36 expression--the dual pathophysiological role of progesterone. The Journal of Biological Chemistry 2016;291:15108-18.
53. Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li LY, Miao QR, Hajjar DP, Duan Y*, Han J*. 2016. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport--an anti-atherogenic function of ERK1/2 inhibition. BBA-Molecular and Cell Biology of Lipid 2016;1861:1180-1191.
54. Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. 2016. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene. Scientific Reports 2016;6:27295.
55.Yang M, Orgah J, Zhu J, Fan G, Han J, Wang X, Zhang B, Zhu Y. Danhong Injection attenuates cardiac injury induced by ischemic and reperfused neuronal cells through regulating arginine vasopressin expression and secretion. Brain Research 2016;1642:516-23.
56. Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X. JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. Oncotarget 2016;7:29387-99.
57. Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y, Chen Y. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochemical and Biophysical Research Communications 2016;473:939-46.
58. Liu M, Zhang W, Li X, Han J, Chen Y, Duan Y. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochemical and Biophysical Research Communications 2016;469;456-462.
59. Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X*, Chen Y*. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology 2016;67:203-11.
