1.科研项目
(1)主持项目
◆2019.01-2022.12:国家自然科学基金资助项目,“昆虫血脑屏障对杀虫剂的阻滞和外排作用及其与棉铃虫抗药性相关机制研究”。
◆2016.1-2017.1:南开大学药物化学生物学国家重点实验室开放基金,“几种生物源化合物杀虫活性的检测及其机理分析”
◆2015.10-2017.12:山药活性成分研究(河南大学横向合作);
◆2014.1-2017.12:国家自然科学基金资助项目,“棉铃虫伤害性感受相关离子通道的功能特性及其与害虫抗药性的关系研究”;
◆2012.2-2014.2:天津市动植物抗性重点实验室开放基金,“拟除虫菊酯剂对棉铃虫神经细胞钙激活钾通道作用机理研究”
◆2011.1-2013.12:国家自然科学基金资助项目,“拟除虫菊酯对棉铃虫幼虫感觉和运动神经元钙激活钾通道作用机理研究”;
◆2011.11-2013.12:教育部留学服务中心留学回国启动基金,“拟除虫菊酯对甜菜夜蛾中枢神经细胞钙激活钾通道作用机理研究”;
◆2006-2008:天津市科技攻关计划培育项目,“农药残留量传感器的研制及其产业化”
◆2002.01-2004.12:国家自然科学基金资助项目,“光学活性杀虫剂对棉铃虫神经细胞钙通道作用机理研究”。
◆2002.03~2004.12:天津市自然科学基金资助项目,用膜片钳技术筛选光学活性杀虫剂。
(2)参加项目
●2012.01-2015.12:国家基础科学人才培养基金,南开大学生物学人才培养基地,J1103503,项目负责人-南开大学刘方
●2008.07-2009.10:以博士后身份参与康奈尔大学(美国NIH项目):Molecular Determinants of Pyrethroid Neurotoxicity,项目负责人--David M. Soderlund
●2003.01-2005.12:国家自然科学基金-面上项目,抗性棉铃虫神经钠、钙通道信号转导和第二信使调控研究,30270884,项目负责人-南开大学刘安西
●2001.01-2003.12:国家自然科学基金-面上项目,以天然先导化合物创制新农药及其立体构效关系研究,20072021,项目负责人-南开大学韩嘉祥
●2000.01-2002.12:国家自然科学基金-面上项目,植物杀虫剂苦皮藤制剂麻醉成分作用机理研究,39970505,项目负责人--西北农林科技大学吴文君
2.论文
第一及通讯作者:
(1)Guangyan Wu, Lin Li, Bo Chen, Chuan Chen, Duqiang Luo*, Bingjun He*. Natural meroterpenoids isolated from the plant pathogenic fungus Verticillium albo-atrum with noteworthy modification action against voltage-gated sodium channels of central neurons of Helicoverpa armigera. Pesticide Biochemistry and Physiology,2018,144C:91-99
(2)Bingjun He and David M. Soderlund. Effects of the β1 Auxiliary Subunit on Modification of Rat Nav1.6 Sodium Channels Expressed in HEK293 Cells by the Pyrethroid Insecticides Tefluthrin and Deltamethrin. Toxicology and Applied Pharmacology, 2016, (291):58–69
(3)韩丽鑫,吴广彦,藏媛媛,贺秉军*. 七氟菊酯和溴氰菊酯对棉铃虫神经细胞内钙离子浓度的影响。天津师范大学学报(自然科学版),2015,35(3):96-101
(4)HE Bing-Jun*, HU Fen, SHANG Xue-Liang, HAN Li-Xin, WU Guang-Yan, LI Jun-Ying, SUN Jin-Sheng*. Molecular Regions Determining the Voltage-dependence of Inactivation for T-type Calcium Channel Cav3.1. Progress in Biochemistry and Biophysics, 2014, 41(9):877-886
(5)Bingjun He, David M. Soderlund. Functional Expression of Rat Nav1.6 Voltage-Gated Sodium Channels in HEK293 Cells: Modulation by the Auxiliary β1 Subunit.PLoS ONE, 2014, 9(1): e85188
(6)郭直岳,王国红,甄静,贺秉军*. 氯虫酰胺对甜菜夜蛾神经元钠离子通道电流的影响。河南农业科学,2013,42(10):79-83
(7)Bingjun He, David M. Soderlund. Differential state-dependent modification of rat Nav1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin. Toxicology and Applied Pharmacology.2011,(257) :377–387
(8)赵佳,韩志杰,刘玉杰,纪炳纯,贺秉军*. 昆虫离子通道及其抗药性研究进展。四川动物,2011,30(5):839-843
(9)Bingjun He, David M. Soderlund. Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Nav1.7 sodium channels.Neuroscience Letters, 2010, (469 ): 268-272
(10)Wang Yong, He Bingjun*, Wu Chunlin, LiuAnxi. Inhibition effects of cyhalothrin on the delayed rectifier potassium current in the central neurons of Helicoverpa armigera. Acta Entomologica Sinica, 2006 , 49 (2) : 235 -240
(11)Yong Wang, Bingjun He*, Qiang Zhao, Zhi Liang and Anxi Liu. Effects of cyhalothrin on the transient outward potassium current in central neurons of Helicoverpa armigera. Insect Science. 2006, 13(1): 13-17
非第一及通讯作者:
(1)David M. Soderlund*, Jianguo Tan, Bingjun He. Functional reconstitution of rat Nav1.6 sodium channels in vitro for studies of pyrethroid action. NeuroToxicology. 2017, 60:142-149
(2)Tiehong Zhu, Yinxia Wang, Bingjun He, Jingjing Zang, Qing He, Weihua Zhang. Islet amyloid polypeptide acts on glucosestimulated beta cells to reduce voltage-gated calcium channel activation, intracellular Ca2+ concentration, and insulin secretion. Diabetes/Metabolism Research and Reviews. 2011, 27: 28-34
(3)Dongbo Liu, Bingjun He, Songyan Han, etc. An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance. Materials Science and Engineering C, 27. 2007, 665–669
(4)Qiang Zhao, Deling Kong, Bingjun He, Yanqiang Liu, Xianlin Fan, Anxi Liu. Pertussis toxin modulation of sodium channels in the central neurons of cyhalothrin-resistant and cyhalothrin-susceptible cotton bollworm, Helicoverpa armigera. Insect Science. 2007, 14(2): 107-115