获奖情况:
1.2013年度中国抗癌协会科技奖二等奖《乙肝病毒致癌分子机制研究》
2.第六届中国侨界贡献(创新团队)奖
3.国家科技进步奖二等奖:《人原发性肝癌发病机制的免疫病理学和分子病理学研究》
4.陕西省科技进步奖一等奖:《肝炎、肝硬变和肝癌发病关系的免疫病理学和分子病理学研究》
代表性论文:
1. Yang G, Feng J, Liu Y, Zhao M, Yuan Y, Yuan H, Yun H, Sun M, Bu Y, Liu L, Liu Z, Niu J, Yin M, Song X, Miao Z, Lin Z, Zhang XD*. HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome.Theranostics, 2019; 9(24):7345-7358
2. Feng J, Yang G, Liu Y, Gao Y, Zhao M, Bu Y, Yuan H, Yuan Y, Yun H, Sun M, Gao H, Zhang S, Liu Z, Yin M, Song X, Miao Z, Lin Z, Zhang XD*. LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer. Theranostics, 2019; 9(18): 5227-5245.
3. Gao Y, Feng JY, Yang G, Zhang SQ, Liu YX, Bu YN, Chen FQ, Zhang WY, Ye LH*, Zhang XD*. HBx-elevated MSL2 modulates HBV cccDNA through inducing degradation of APOBEC3B to enhance hepatocarcinogenesis. Hepatology, 2017 Nov;66(5):1413-1429.
4. Feng GX, Li J, Yang Z, Zhang,SQ, Liu YX,Zhang WY, Ye LH* and Zhang XD*. Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through down-regulation of miR-30e targeting P4HA2 mRNA. Oncogene,2017 Dec 14;36(50):6895-6905
5. Zhao Y, Li H, Zhang Y, Li L, Fang R, Li Y, Liu Q, Zhang W, Qiu L, Liu F, Zhang XD*, and Ye LH*. The Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism of Breast Cancer through Activating LXRs/SREBP-1c/FAS Signaling. Cancer Res.2016, Mar 15,76(16):4696-707
6. Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang XD*, Ye LH*. HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.Cancer Res.2016 Jan 15;76(2):293-304.
7. Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang XD*, Ye L*Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.Oncogene. 2016;35(31): 4048-57
8. Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye LH*, Zhang XD*. Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9–Mediated RXRA Signaling Pathway. Cancer Res, 2015;75(5): 846-857
9. Zhang W, Lu Z,Kong G, Gao Y, Wang T, Wang Q, Cai N, Wang H, Liu F, Ye LH* and Zhang XD*. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. Molecular Cancer,2014, 13:128,
10. You X, Liu F, Zhang T, Lv N, Liu Q, Shan C, Du Y, Kong G, Wang T, Ye LH* and Zhang XD*. Hepatitis B virus X protein up-regulates Lin
11. Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Ye LH* and Zhang XD*. Hepatitis B Virus X Protein (HBx) Modulates Oncogene YAP via CREB to Promote Growth of Hepatoma Cells. Hepatology, 2012; 56(6): 2051-9
12. Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*.MicroRNA-520e Suppresses Growth of Hepatoma Cells by Targeting the NF-κB-inducing Kinase (NIK). Oncogene, 2012; 31(31):3607-20.
13. Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010; 20(5):563-75
14. Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye LH*, Zhang XD*. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells. Cell Res 2008;18:500-507



