主持科研项目:
(1)国家自然科学基金委,创新研究群体项目,组织器官损伤的修复与再生,81921004,2020.01-2024.12,1050万元。
(2)国家自然科学基金重点项目,生物活性载体材料调控干细胞和组织微环境治疗急性肾损伤,81830060,2019.01.01- 2023.12.31,直接经费:294万元。主持人:孔德领;
(3)国家重点研发计划项目, 新型响应性智能水凝胶的设计、制备及工程化技术, 1396万元, 2017YFC1103500,2017.07-2020.12,直接经费: 1396万元。主持人:孔德领;
(4)国家自然科学基金重点项目, 生物活性小口径人工血管的构建及诱导血管再生机制研究。项目批准号81530059,2016.01-2020.12,经费:326万元。主持人:孔德领;
(5)国家自然科学基金面上项目,间充质干细胞工程化培养增强其免疫治疗作用的研究,31771066,018.01-2021.12,直接经费:63万元,主持人:孔德领;
(6)天津市科技支撑重点项目,增强血管化骨修复材料新产品研制,16YFZCSY01020, 2016.04-2019.03。经费30万元,主持人:孔德领;
(7)国家自然科学基金国际(地区)合作与交流项目,重大合作研究项目,分子影像学方法示踪干细胞移植治疗心肌梗死研究,81220108015,2013.01-2017.12。经费300万元,主持人:孔德领;
(8)国家自然科学基金面上项目,小口径人工血管研究中内皮干细胞捕捉的生物学和病理学评价,81171478,2012.01-2015.12。经费60万元,主持人:孔德领;
(9)国家自然科学基金重点项目,小口径血管材料结构设计与组织再生,项目批准号:50830104,2009.01-2012.12。经费200万元,主持人:孔德领;
部分代表论文:
(1)Midgley AC*, Wei Y, Zhu D, Gao F, Yan H, Khalique A, Luo W, Jiang H, Liu X, Guo J, Zhang C, Feng G, Wang K, Bai X, Ning W, Yang C, Zhao Q,Kong D*. Multifunctional Natural Polymer Nanoparticles as Antifibrotic Gene Carriers for CKD Therapy. J Am Soc Nephrol. 2020 Aug 7:ASN.2019111160.
(2)Ran Zhang, Wenya Luo, Yue Zhang, Dashuai Zhu, Adam C. Midgley, Hao Song, Anila Khalique, Haoqi Zhang, Jie Zhuang, Deling Kong*, Xinglu Huang*. Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases. Science Advances 2020 May 6: eaaz8011.
(3)Hongyu Yan, Xingyan Mi, Adam C. Midgley, Xinchen Du, Ziqi Huang, Tingting Wei, Ruihua Liu, Tengzhi Ma, Dengke Zhi, Dashuai Zhu, Ting Wang, Guowei Feng, Ying Zhao, Weiye Zhang, Ju He, Meifeng Zhu*, Deling Kong*, Kai Wang*. Targeted Repair of Vascular Injury by Adipose‐Derived Stem Cells Modified with P‐Selectin Binding Peptide. Advanced Science, 2020 April 22;1903516, DOI: 10.1002/advs.201903516.
(4)Wu P, Wang L, Li W, Zhang Y, Wu Y, Zhi D, Wang H, Wang L, Kong D*, Zhu M*. Construction of vascular graft with circumferentially oriented microchannels for improving artery regeneration. Biomaterials. 2020 Mar 4;242:119922.
(5)Mao D, Zhang C, Kenry, Liu J, Wang X, Li B, Yan H, Hu F, Kong D*, Wang Z*, Liu B*. Bio-orthogonal click reaction-enabled highly specific in situ cellularization of tissue engineering scaffolds. Biomaterials. 2020 Feb;230:119615.
(6)Gao F, Wu J, Gao H, Hu X, Liu L, Midgley AC, Liu Q, Sun Z, Liu Y, Ding D, Wang Y, Kong D*, Huang X*. Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics. Biomaterials. 2020 Feb;230:119635.
(7)Zhu M, Li W, Xianhao Dong , Xingyu Yuan , Adam C Midgley, Hong Chang, Yuhao Wang, Haoyu Wang, Kai Wang*, Peter X Ma, Hongjun Wang*,Deling Kong*. In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration. Nature Communications. 2019 Oct 11;10(1):4620.
(8)Li W, Midgley AC, Bai Y, Zhu M*, Chang H, Zhu W, Wang L, Wang Y, Wang H, Kong D*. Subcutaneously engineered autologous extracellular matrix scaffolds with aligned microchannels for enhanced tendon regeneration: Aligned microchannel scaffolds for tendon repair. Biomaterials. 2019 Dec;224:119488.
(9)Dong X, Yuan X, Wang L, Liu J, Midgley AC, Wang Z, Wang K, Liu J, Zhu M*,Kong D*. Construction of a bilayered vascular graft with smooth internal surface for improved hemocompatibility and endothelial cell monolayer formation. Biomaterials. 2018 Oct;181:1-14.
(10)Zhu M, Wu Y, Li W, Dong X, Chang H, Wang K, Wu P, Zhang J, Fan G, Wang L, Liu J, Wang H*, Kong D*. Biodegradable and elastomeric vascular grafts enable vascular remodeling. Biomaterials. 2018 Nov;183:306-318.
(11)Yang P, Song H, Qin Y, Huang P, Zhang C, Kong D*, Wang W*. Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity. Nano Lett. 2018 Jul 11;18(7):4377-4385.
(12)Duo Mao, Fang Hu, Kenry, Shenglu Ji, Wenbo Wu, Dan Ding, Deling Kong*, Bin Liu*. Metal-organic framework-assisted in vivo bacterial metabolic labeling and precise antibacterial therapy. Advanced Materials.2018 May;30(18):e1706831.
(13)Huijuan Song, Pingsheng Huang, Jinfeng Niu, Gaona Shi, Chuangnian Zhang, Deling Kong*, Weiwei Wang*. Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma. Biomaterials 2018 Jan 3;159:119-129.
科研奖励:
2009年获得国家科技进步二等奖,“高性能血液净化医用吸附树脂的创制”(第四完成人)
2010年天津市自然科学二等奖,“结合干细胞及基因疗法的心血管组织工程研究”(第一完成人)
2014年天津市自然科学一等奖,“超分子水凝胶的制备及生物医疗应用”(第四完成人)
2016年天津市科技进步二等奖,“糖尿病并发心血管疾病新型疗法的基础与应用研究”(第五完成人)
2018年天津市自然科学二等奖,“真菌疏水蛋白自组装分子机制和材料表面修饰功能的研究”(第六完成人)
2018年天津市科学技术进步二等奖,“用于生物活性物质递送的纳米和水凝胶载体的构建和应用”(第三完成人)
2019年天津市自然科学一等奖,“生物活性材料在治疗缺血性疾病中的促血管再生作用”(第一完成人)
2019年“心血管生物材料与组织工程团队”获得天津市模范集体